TY - JOUR
T1 - Epidemiology of subtypes of hyperthyroidism in Denmark - a population-based study
AU - Carle, Allan
AU - Pedersen, Inge Bülow
AU - Knudsen, Nils Jakob
AU - Perrild, Hans
AU - Ovesen, Lars
AU - Rasmussen, Lone
AU - Laurberg, Peter
PY - 2011/2/28
Y1 - 2011/2/28
N2 - Objective: Few population-based studies have described the epidemiology of subtypes of hyperthyroidism. Design: A prospective population-based study, monitoring two well-defined Danish cohorts in Aalborg with moderate iodine deficiency (n=311,102) and Copenhagen with only mild iodine deficiency (n=227,632). Methods: A laboratory monitoring system identified subjects with thyroid function tests suggesting overt hyperthyroidism (low s-thyrotropin combined with high s-thyroxine or s-triiodothyronine). For all subjects we collected information on medical history, thyroid scintigraphy, and thyroid hormone receptor antibody (TRAb) measurement. Information was used to disprove or verify primary overt hyperthyroidism and to subclassify hyperthyroidism into nosological disorders. Results: From 1997 to 2000 (2,027,208 person-years of observation) we verified 1,682 new cases of overt hyperthyroidism. The overall standardized incidence rate (SIR) per 100,000 person-years was 81.6, and was higher in Aalborg compared to Copenhagen (96.7 vs. 60.0, p
AB - Objective: Few population-based studies have described the epidemiology of subtypes of hyperthyroidism. Design: A prospective population-based study, monitoring two well-defined Danish cohorts in Aalborg with moderate iodine deficiency (n=311,102) and Copenhagen with only mild iodine deficiency (n=227,632). Methods: A laboratory monitoring system identified subjects with thyroid function tests suggesting overt hyperthyroidism (low s-thyrotropin combined with high s-thyroxine or s-triiodothyronine). For all subjects we collected information on medical history, thyroid scintigraphy, and thyroid hormone receptor antibody (TRAb) measurement. Information was used to disprove or verify primary overt hyperthyroidism and to subclassify hyperthyroidism into nosological disorders. Results: From 1997 to 2000 (2,027,208 person-years of observation) we verified 1,682 new cases of overt hyperthyroidism. The overall standardized incidence rate (SIR) per 100,000 person-years was 81.6, and was higher in Aalborg compared to Copenhagen (96.7 vs. 60.0, p
U2 - 10.1530/EJE-10-1155
DO - 10.1530/EJE-10-1155
M3 - Journal article
C2 - 21357288
SN - 0804-4643
VL - 164
SP - 801
EP - 809
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
IS - 5
ER -