Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: a Danish genome-wide association study

Henrik Christian Bidstrup Leffers; David Westergaard; Saedis Saevarsdottir; Ingileif Jonsdottir; Ole Birger Pedersen; DBDS Genomic Consortium; Anne Troldborg; Anne Voss; Salome Kristensen; Jesper Lindhardsen; Prabhat Kumar; Asta Linauskas; Lars Juul; Niels Steen Krogh; Bent Deleuran; Lene Dreyer; Michael Schwinn; Lise Wegner Thørner; Lotte Hindhede; Christian Erikstrup; Henrik Ullum; Søren Brunak; Kari Stefansson; Karina Banasik; Søren Jacobsen

doi:10.1016/j.jbspin.2022.105357

Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: a Danish genome-wide association study

Henrik Christian Bidstrup Leffers^*, David Westergaard, Saedis Saevarsdottir, Ingileif Jonsdottir, Ole Birger Pedersen, DBDS Genomic Consortium, Anne Troldborg, Anne Voss, Salome Kristensen, Jesper Lindhardsen, Prabhat Kumar, Asta Linauskas, Lars Juul, Niels Steen Krogh, Bent Deleuran, Lene Dreyer, Michael Schwinn, Lise Wegner Thørner, Lotte Hindhede, Christian ErikstrupHenrik Ullum, Søren Brunak, Kari Stefansson, Karina Banasik, Søren Jacobsen

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › Research › peer-review

1 Citation (Scopus)

Original language	English
Article number	105357
Journal	Joint bone spine
Volume	89
Issue number	4
ISSN	1297-319X
DOIs	https://doi.org/10.1016/j.jbspin.2022.105357
Publication status	Published - Jul 2022

Keywords

Clinical phenotype
Disease manifestations
GWAS
Genome wide association study
Lupus Nephritis
SLE
Systemic Lupus Erythematosus

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Leffers, H. C. B., Westergaard, D., Saevarsdottir, S., Jonsdottir, I., Pedersen, O. B., DBDS Genomic Consortium, Troldborg, A., Voss, A., Kristensen, S., Lindhardsen, J., Kumar, P., Linauskas, A., Juul, L., Krogh, N. S., Deleuran, B., Dreyer, L., Schwinn, M., Thørner, L. W., Hindhede, L., ... Jacobsen, S. (2022). Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: a Danish genome-wide association study. Joint bone spine, 89(4), Article 105357. https://doi.org/10.1016/j.jbspin.2022.105357

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title = "Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: a Danish genome-wide association study",

keywords = "Clinical phenotype, Disease manifestations, GWAS, Genome wide association study, Lupus Nephritis, SLE, Systemic Lupus Erythematosus",

author = "Leffers, {Henrik Christian Bidstrup} and David Westergaard and Saedis Saevarsdottir and Ingileif Jonsdottir and Pedersen, {Ole Birger} and {DBDS Genomic Consortium} and Anne Troldborg and Anne Voss and Salome Kristensen and Jesper Lindhardsen and Prabhat Kumar and Asta Linauskas and Lars Juul and Krogh, {Niels Steen} and Bent Deleuran and Lene Dreyer and Michael Schwinn and Th{\o}rner, {Lise Wegner} and Lotte Hindhede and Christian Erikstrup and Henrik Ullum and S{\o}ren Brunak and Kari Stefansson and Karina Banasik and S{\o}ren Jacobsen",

year = "2022",

month = jul,

doi = "10.1016/j.jbspin.2022.105357",

language = "English",

volume = "89",

journal = "Joint bone spine",

issn = "1297-319X",

publisher = "Elsevier",

number = "4",

}

Leffers, HCB, Westergaard, D, Saevarsdottir, S, Jonsdottir, I, Pedersen, OB, DBDS Genomic Consortium, Troldborg, A, Voss, A, Kristensen, S, Lindhardsen, J, Kumar, P , Linauskas, A, Juul, L, Krogh, NS, Deleuran, B, Dreyer, L, Schwinn, M, Thørner, LW, Hindhede, L, Erikstrup, C, Ullum, H, Brunak, S, Stefansson, K, Banasik, K & Jacobsen, S 2022, 'Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: a Danish genome-wide association study', Joint bone spine, vol. 89, no. 4, 105357. https://doi.org/10.1016/j.jbspin.2022.105357

Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: a Danish genome-wide association study. / Leffers, Henrik Christian Bidstrup; Westergaard, David; Saevarsdottir, Saedis et al.
In: Joint bone spine, Vol. 89, No. 4, 105357, 07.2022.

Research output: Contribution to journal › Comment/debate › Research › peer-review

TY - JOUR

T1 - Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations

T2 - a Danish genome-wide association study

AU - Leffers, Henrik Christian Bidstrup

AU - Westergaard, David

AU - Saevarsdottir, Saedis

AU - Jonsdottir, Ingileif

AU - Pedersen, Ole Birger

AU - DBDS Genomic Consortium

AU - Troldborg, Anne

AU - Voss, Anne

AU - Kristensen, Salome

AU - Lindhardsen, Jesper

AU - Kumar, Prabhat

AU - Linauskas, Asta

AU - Juul, Lars

AU - Krogh, Niels Steen

AU - Deleuran, Bent

AU - Dreyer, Lene

AU - Schwinn, Michael

AU - Thørner, Lise Wegner

AU - Hindhede, Lotte

AU - Erikstrup, Christian

AU - Ullum, Henrik

AU - Brunak, Søren

AU - Stefansson, Kari

AU - Banasik, Karina

AU - Jacobsen, Søren

PY - 2022/7

Y1 - 2022/7

KW - Clinical phenotype

KW - Disease manifestations

KW - GWAS

KW - Genome wide association study

KW - Lupus Nephritis

KW - SLE

KW - Systemic Lupus Erythematosus

UR - http://www.scopus.com/inward/record.url?scp=85125522423&partnerID=8YFLogxK

U2 - 10.1016/j.jbspin.2022.105357

DO - 10.1016/j.jbspin.2022.105357

M3 - Comment/debate

C2 - 35167971

SN - 1297-319X

VL - 89

JO - Joint bone spine

JF - Joint bone spine

IS - 4

M1 - 105357

ER -

Leffers HCB, Westergaard D, Saevarsdottir S, Jonsdottir I, Pedersen OB, DBDS Genomic Consortium et al. Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: a Danish genome-wide association study. Joint bone spine. 2022 Jul;89(4):105357. Epub 2022 Feb 12. doi: 10.1016/j.jbspin.2022.105357

Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: a Danish genome-wide association study

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