Evaluation of the tolerability and immunogenicity of ultraviolet C-irradiated autologous platelets in a dog model

Petra Pohler; Jörg Lehmann; Verena Veneruso; Janina Tomm; Martin von Bergen; Bernd Lambrecht; Barbara Kohn; Christiane Weingart; Thomas H Müller; Axel Seltsam; Martin von Bergen

doi:10.1111/j.1537-2995.2012.03583.x

Evaluation of the tolerability and immunogenicity of ultraviolet C-irradiated autologous platelets in a dog model

Petra Pohler, Jörg Lehmann, Verena Veneruso, Janina Tomm, Martin von Bergen, Bernd Lambrecht, Barbara Kohn, Christiane Weingart, Thomas H Müller, Axel Seltsam, Martin von Bergen

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Abstract

The THERAFLEX ultraviolet (UV) platelets (PLTs) pathogen reduction system for PLT concentrates (PCs) operates using ultraviolet C (UVC) light at a wavelength of 254 nm. UVC treatment can potentially alter proteins, which may affect drug tolerance in humans and influence the immunogenicity of blood products. This preclinical study in beagle dogs was designed to evaluate the safety pharmacology of UVC-irradiated PCs after intravenous administration and to determine whether they are capable of eliciting humoral responses to PLTs and plasma proteins.

Original language	English
Journal	Transfusion
Volume	52
Issue number	11
Pages (from-to)	2414-26
Number of pages	13
ISSN	0041-1132
DOIs	https://doi.org/10.1111/j.1537-2995.2012.03583.x
Publication status	Published - Nov 2012
Externally published	Yes

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title = "Evaluation of the tolerability and immunogenicity of ultraviolet C-irradiated autologous platelets in a dog model",

abstract = "The THERAFLEX ultraviolet (UV) platelets (PLTs) pathogen reduction system for PLT concentrates (PCs) operates using ultraviolet C (UVC) light at a wavelength of 254 nm. UVC treatment can potentially alter proteins, which may affect drug tolerance in humans and influence the immunogenicity of blood products. This preclinical study in beagle dogs was designed to evaluate the safety pharmacology of UVC-irradiated PCs after intravenous administration and to determine whether they are capable of eliciting humoral responses to PLTs and plasma proteins.",

author = "Petra Pohler and J{\"o}rg Lehmann and Verena Veneruso and Janina Tomm and {von Bergen}, Martin and Bernd Lambrecht and Barbara Kohn and Christiane Weingart and M{\"u}ller, {Thomas H} and Axel Seltsam and {von Bergen}, Martin",

note = "{\textcopyright} 2012 American Association of Blood Banks.",

year = "2012",

month = nov,

doi = "10.1111/j.1537-2995.2012.03583.x",

language = "English",

volume = "52",

pages = "2414--26",

journal = "Transfusion",

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TY - JOUR

T1 - Evaluation of the tolerability and immunogenicity of ultraviolet C-irradiated autologous platelets in a dog model

AU - Pohler, Petra

AU - Lehmann, Jörg

AU - Veneruso, Verena

AU - Tomm, Janina

AU - von Bergen, Martin

AU - Lambrecht, Bernd

AU - Kohn, Barbara

AU - Weingart, Christiane

AU - Müller, Thomas H

AU - Seltsam, Axel

AU - von Bergen, Martin

PY - 2012/11

Y1 - 2012/11

N2 - The THERAFLEX ultraviolet (UV) platelets (PLTs) pathogen reduction system for PLT concentrates (PCs) operates using ultraviolet C (UVC) light at a wavelength of 254 nm. UVC treatment can potentially alter proteins, which may affect drug tolerance in humans and influence the immunogenicity of blood products. This preclinical study in beagle dogs was designed to evaluate the safety pharmacology of UVC-irradiated PCs after intravenous administration and to determine whether they are capable of eliciting humoral responses to PLTs and plasma proteins.

AB - The THERAFLEX ultraviolet (UV) platelets (PLTs) pathogen reduction system for PLT concentrates (PCs) operates using ultraviolet C (UVC) light at a wavelength of 254 nm. UVC treatment can potentially alter proteins, which may affect drug tolerance in humans and influence the immunogenicity of blood products. This preclinical study in beagle dogs was designed to evaluate the safety pharmacology of UVC-irradiated PCs after intravenous administration and to determine whether they are capable of eliciting humoral responses to PLTs and plasma proteins.

U2 - 10.1111/j.1537-2995.2012.03583.x

DO - 10.1111/j.1537-2995.2012.03583.x

M3 - Journal article

C2 - 22404822

SN - 0041-1132

VL - 52

SP - 2414

EP - 2426

JO - Transfusion

JF - Transfusion

IS - 11

ER -

Evaluation of the tolerability and immunogenicity of ultraviolet C-irradiated autologous platelets in a dog model

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