TY - JOUR
T1 - Exploring the Role of Hyaluronic Acid in Reproductive Biology and Beyond
T2 - Applications in Assisted Reproduction and Tissue Engineering
AU - Rashki Ghaleno, Leila
AU - Pennisi, Cristian Pablo
AU - Shahverdi, Abdolhossein
AU - Dardmeh, Fereshteh
AU - Alipour, Hiva
AU - Rezazadeh Valojerdi, Mojtaba
N1 - © 2024 The Authors. Advanced Biology published by Wiley‐VCH GmbH.
PY - 2024/6
Y1 - 2024/6
N2 - Hyaluronic acid (HA) plays a prominent role in various aspects of reproductive biology and assisted reproductive technologies (ART). This review describes the multifaceted influence of HA, ranging from primordial germ cell migration, ovarian follicle development, and ovulation in females to sperm structure, physiology, motility, and capacitation in males. In addition, HA also plays an important role in fertilization and promotes embryo implantation by mediating cellular adhesion and communication within the uterus. Against this physiological background, the review examines the current applications of HA in the context of ART. In addition, the article addresses the emerging field of reproductive tissue engineering, where HA-based hydrogels offer promising perspectives as they can support the development of mature oocytes and spermatogenesis in vitro. Overall, this review highlights the integral role of HA in the intricate mechanisms of reproductive biology and its growing importance for improving ART outcomes and the field of tissue engineering of the reproductive system.
AB - Hyaluronic acid (HA) plays a prominent role in various aspects of reproductive biology and assisted reproductive technologies (ART). This review describes the multifaceted influence of HA, ranging from primordial germ cell migration, ovarian follicle development, and ovulation in females to sperm structure, physiology, motility, and capacitation in males. In addition, HA also plays an important role in fertilization and promotes embryo implantation by mediating cellular adhesion and communication within the uterus. Against this physiological background, the review examines the current applications of HA in the context of ART. In addition, the article addresses the emerging field of reproductive tissue engineering, where HA-based hydrogels offer promising perspectives as they can support the development of mature oocytes and spermatogenesis in vitro. Overall, this review highlights the integral role of HA in the intricate mechanisms of reproductive biology and its growing importance for improving ART outcomes and the field of tissue engineering of the reproductive system.
KW - assisted reproductive technologies
KW - hyaluronic acid
KW - ovarian tissue engineering
KW - reproductive biomedicine
KW - sperm selection
UR - http://www.scopus.com/inward/record.url?scp=85189292910&partnerID=8YFLogxK
U2 - 10.1002/adbi.202300621
DO - 10.1002/adbi.202300621
M3 - Review article
C2 - 38580620
SN - 2701-0198
VL - 8
JO - Advanced biology
JF - Advanced biology
IS - 6
M1 - 2300621
ER -