Extracellular vesicle-associated proteins as potential biomarkers

Anne Sophie Schou, Jonas Ellegaard Nielsen, Anders Askeland, Malene Møller Jørgensen*

*Corresponding author for this work

Research output: Contribution to book/anthology/report/conference proceedingBook chapterResearchpeer-review

6 Citations (Scopus)


Every cell in the body secretes extracellular vesicles (EVs) possibly as cellular signaling components and these cell-derivatives can be found in multiple numbers in biological fluids. EVs have in the scientific field received great attention in relation to pathophysiology and disease diagnostics. Altered protein expressions associated with circulating EVs in diseased individuals can serve as biomarkers for different disease states. This capacity paves the way for non-invasive screening tools and early diagnostic markers. However, no isolation method of EVs has been acknowledged as the “golden standard,” thus reproducibility of the studies remains inadequate. Increasing interest in EV proteins as disease biomarkers could give rise to more scientific knowledge with diagnostic applicability. In this chapter, studies of proteins believed to be associated with EVs within cancer, autoimmunity, metabolic and neurodegenerative diseases have been outlined.

Original languageEnglish
Title of host publicationAdvances in Clinical Chemistry
EditorsGregory S. Makowski
Number of pages48
PublisherAcademic Press
Publication date2020
ISBN (Electronic)9780128215609
Publication statusPublished - 2020
SeriesAdvances in Clinical Chemistry


  • Autoimmunity
  • Biological fluids
  • Biomarker
  • Cancer
  • Diagnostic
  • EVs
  • Exosomes
  • Extracellular vesicles
  • Human
  • Metabolic disease
  • Microparticles
  • Neurodegenerative disorders
  • Protein expression


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