Extraction, Isolation, and Purification of Value-Added Chemicals from Lignocellulosic Biomass

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This review covers the operating conditions for extracting top value-added chemicals, such as levulinic acid, lactic acid, succinic acid, vanillic acid, 3-hydroxypropionic acid, xylitol, 2,5-furandicarboxylic acid, 5-hydroxymethyl furfural, chitosan, 2,3-butanediol, and xylo-oligosaccharides, from common lignocellulosic biomass. Operating principles of novel extraction methods, beyond pretreatments, such as Soxhlet extraction, ultrasound-assisted extraction, and enzymatic extraction, are also presented and reviewed. Post extraction, high-value biochemicals need to be isolated, which is achieved through a combination of one or more isolation and purification steps. The operating principles, as well as a review of isolation methods, such as membrane filtration and liquid–liquid extraction and purification using preparative chromatography, are also discussed.

Original languageEnglish
Article number1752
Issue number9
Publication statusPublished - Sep 2022

Bibliographical note

Funding Information:
This review was funded by the Aqua Combine Project of the European Union’s Horizon 2020 research and innovation program under Grant Agreement No. 862834.

Publisher Copyright:
© 2022 by the authors.


  • extraction
  • isolation
  • lignocellulose biomass
  • pretreatment
  • value-added chemicals


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