TY - JOUR
T1 - Female Sex as a Risk Modifier for Stroke Risk in Atrial Fibrillation
T2 - Using CHA2DS2-VASc versus CHA2DS2-VA for Stroke Risk Stratification in Atrial Fibrillation: A Note of Caution
AU - Nielsen, Peter Brønnum
AU - Overvad, Thure Filskov
PY - 2020/6
Y1 - 2020/6
N2 - Stroke prevention is a key clinical concern in the management of patients with atrial fibrillation. Oral anticoagulation treatment reduces the risk of disabling stroke, but the treatment increases the risk of bleeding. For decades, the decision to initiate oral anticoagulation has been guided by clinical risk scoring systems such as the CHADS2 and CHA2DS2-VASc scores. In this narrative review, we focus on the recent discussion of the "Sc" (Sex Category) criterion in the CHA2DS2-VASc score. Epidemiological considerations when assessing stroke rates in cohorts are discussed, and the implications of different methodological approaches are outlined. Next, we review studies investigating the association of the "Sc" criterion on the stroke rates under various approaches. Lastly, we discuss potential consequences of implementing the recently suggested sex-less CHA2DS2-VA score, which leaves out female sex from stroke risk assessment in atrial fibrillation.
AB - Stroke prevention is a key clinical concern in the management of patients with atrial fibrillation. Oral anticoagulation treatment reduces the risk of disabling stroke, but the treatment increases the risk of bleeding. For decades, the decision to initiate oral anticoagulation has been guided by clinical risk scoring systems such as the CHADS2 and CHA2DS2-VASc scores. In this narrative review, we focus on the recent discussion of the "Sc" (Sex Category) criterion in the CHA2DS2-VASc score. Epidemiological considerations when assessing stroke rates in cohorts are discussed, and the implications of different methodological approaches are outlined. Next, we review studies investigating the association of the "Sc" criterion on the stroke rates under various approaches. Lastly, we discuss potential consequences of implementing the recently suggested sex-less CHA2DS2-VA score, which leaves out female sex from stroke risk assessment in atrial fibrillation.
KW - cardiology
KW - epidemiological studies
KW - stroke/prevention
UR - http://www.scopus.com/inward/record.url?scp=85085960156&partnerID=8YFLogxK
U2 - 10.1055/s-0040-1710014
DO - 10.1055/s-0040-1710014
M3 - Review article
C2 - 32316064
SN - 0340-6245
VL - 120
SP - 894
EP - 898
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
IS - 6
ER -