Frequency and impact of obstetric complications prior and subsequent to unexplained secondary recurrent miscarriage

H S Nielsen, R Steffensen, M Lund, L Egestad, L H Mortensen, A-M N Andersen, Ø Lidegaard, O B Christiansen

Research output: Contribution to journalJournal articleResearchpeer-review

52 Citations (Scopus)

Abstract

The chance of a live birth after a diagnosis of secondary recurrent miscarriage (SRM) is reduced in patients who, prior to the miscarriages, gave birth to a boy and carry HLA class II alleles that efficiently present male-specific (H-Y) antigens to the immune system. Information about obstetric complications in births prior and subsequent to the SRM diagnosis is limited. The relations between maternal carriage of H-Y-restricting HLA, fetal sex, obstetric complications and prognosis are unknown.
Original languageEnglish
JournalHuman reproduction (Oxford, England)
Volume25
Pages (from-to)1543-52
Number of pages10
DOIs
Publication statusPublished - 1 Jun 2010
Externally publishedYes

Keywords

  • Abortion, Habitual
  • Alleles
  • Denmark
  • Female
  • H-Y Antigen
  • HLA Antigens
  • Histocompatibility, Maternal-Fetal
  • Humans
  • Infant, Newborn
  • Live Birth
  • Male
  • Pregnancy
  • Pregnancy Complications
  • Registries
  • Risk Factors
  • Statistics, Nonparametric

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