Frequency of HLA-B27 subtypes in a Danish population and in Danish patients with ankylosing spondylitis

John Bæch; Søren Schmidt Olsen; R Steffensen; K Varming; Niels Grunnet; C Jersild

Frequency of HLA-B27 subtypes in a Danish population and in Danish patients with ankylosing spondylitis

John Bæch, Søren Schmidt Olsen, R Steffensen, K Varming, Niels Grunnet, C Jersild

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Polymerase chain reaction in combination with sequence-specific oligonucleotide probes were used to analyze nine HLA-B27 subtypes among 51 healthy HLA-B27 positive Danish blood donors and 30 Danish HLA-B27 positive patients with ankylosing spondylitis (AS). In the group of healthy Danes we found two subtypes, B*2705 (90.2%) and B*2702 (9.8%), however, among the AS patients only the B*2705 subtype was detected. We did not find a significant evidence for associations between AS and a particular HLA-B27 subtype in a Danish population.

Original language	English
Journal	HLA
Volume	49
Issue number	5
Pages (from-to)	499-502
Number of pages	4
ISSN	2059-2302
Publication status	Published - May 1997
Externally published	Yes

Keywords

Denmark
Gene Frequency
HLA-B27 Antigen
Humans
Spondylitis, Ankylosing

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http://onlinelibrary.wiley.com/doi/10.1111/j.1399-0039.1997.tb02785.x/epdf

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@article{3975d8c9bfb649128b5f711fac375fa4,

title = "Frequency of HLA-B27 subtypes in a Danish population and in Danish patients with ankylosing spondylitis",

abstract = "Polymerase chain reaction in combination with sequence-specific oligonucleotide probes were used to analyze nine HLA-B27 subtypes among 51 healthy HLA-B27 positive Danish blood donors and 30 Danish HLA-B27 positive patients with ankylosing spondylitis (AS). In the group of healthy Danes we found two subtypes, B*2705 (90.2%) and B*2702 (9.8%), however, among the AS patients only the B*2705 subtype was detected. We did not find a significant evidence for associations between AS and a particular HLA-B27 subtype in a Danish population.",

keywords = "Denmark, Gene Frequency, HLA-B27 Antigen, Humans, Spondylitis, Ankylosing",

author = "John B{\ae}ch and Olsen, {S{\o}ren Schmidt} and R Steffensen and K Varming and Niels Grunnet and C Jersild",

year = "1997",

month = may,

language = "English",

volume = "49",

pages = "499--502",

journal = "HLA",

issn = "2059-2302",

publisher = "Wiley",

number = "5",

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TY - JOUR

T1 - Frequency of HLA-B27 subtypes in a Danish population and in Danish patients with ankylosing spondylitis

AU - Bæch, John

AU - Olsen, Søren Schmidt

AU - Steffensen, R

AU - Varming, K

AU - Grunnet, Niels

AU - Jersild, C

PY - 1997/5

Y1 - 1997/5

N2 - Polymerase chain reaction in combination with sequence-specific oligonucleotide probes were used to analyze nine HLA-B27 subtypes among 51 healthy HLA-B27 positive Danish blood donors and 30 Danish HLA-B27 positive patients with ankylosing spondylitis (AS). In the group of healthy Danes we found two subtypes, B*2705 (90.2%) and B*2702 (9.8%), however, among the AS patients only the B*2705 subtype was detected. We did not find a significant evidence for associations between AS and a particular HLA-B27 subtype in a Danish population.

AB - Polymerase chain reaction in combination with sequence-specific oligonucleotide probes were used to analyze nine HLA-B27 subtypes among 51 healthy HLA-B27 positive Danish blood donors and 30 Danish HLA-B27 positive patients with ankylosing spondylitis (AS). In the group of healthy Danes we found two subtypes, B*2705 (90.2%) and B*2702 (9.8%), however, among the AS patients only the B*2705 subtype was detected. We did not find a significant evidence for associations between AS and a particular HLA-B27 subtype in a Danish population.

KW - Denmark

KW - Gene Frequency

KW - HLA-B27 Antigen

KW - Humans

KW - Spondylitis, Ankylosing

M3 - Journal article

C2 - 9174143

SN - 2059-2302

VL - 49

SP - 499

EP - 502

JO - HLA

JF - HLA

IS - 5

ER -

Frequency of HLA-B27 subtypes in a Danish population and in Danish patients with ankylosing spondylitis

Abstract

Keywords

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