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Gender Minority Stress and Resilience, Mental Health and Wellbeing in Transgender and Gender-Diverse Individuals: A Narrative Review

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Abstract

Purpose of Review: Transgender and gender diverse (TGD) individuals experience disproportionate mental health burdens compared to cisgender heterosexual, lesbian, gay and bisexual populations. The Gender Minority Stress and Resilience (GMSR) framework explains how systemic prejudice drives these disparities. Our narrative review synthetizes recent expansions of the model, including novel psychological mediators, integrative frameworks and criticisms. Recent Findings: The literature underscores the complex, socially embedded relationships between GMSR factors and mental health. Moreover, the distress related to gender incongruence may be reconceptualized as emerging from dynamic transactions between the social settings and the individual. Social invalidation, rejection and non-affirmation of gender identity in the developmental age can also impact wellbeing as forms of Gender Minority Stress. Summary: Attributing mental health challenges to internal identity processes needs to shift toward systemic invalidation as a key driver, centering the diversity of TGD experiences, beyond narratives of suffering, as positive journeys of gender affirmation.

Original languageEnglish
Article number18
JournalCurrent Sexual Health Reports
Volume17
Issue number1
Number of pages12
ISSN1548-3584
DOIs
Publication statusPublished - Dec 2025

Bibliographical note

Publisher Copyright:
© The Author(s) 2025.

Keywords

  • Mental wellbeing
  • Minority stress
  • Narrative review
  • Quality of life
  • Resilience
  • Transgender persons

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