Genes involved in pruning and inflammation are enriched in a large mega-sample of patients affected by Schizophrenia and Bipolar Disorder and controls

Marco Calabrò; Calabrò Marco; Antonio Drago; Drago Antonio; Antonina Sidoti; Sidoti Antonina; Alessandro Serretti; Serretti Alessandro; Concetta Crisafulli; Crisafulli Concetta

doi:10.1016/j.psychres.2015.06.013

Genes involved in pruning and inflammation are enriched in a large mega-sample of patients affected by Schizophrenia and Bipolar Disorder and controls

Marco Calabrò, Calabrò Marco, Antonio Drago, Drago Antonio, Antonina Sidoti, Sidoti Antonina, Alessandro Serretti, Serretti Alessandro, Concetta Crisafulli, Crisafulli Concetta

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

Abstract

A molecular pathway analysis has been performed in order to complement previous genetic investigations on Schizophrenia. 4486 Schizophrenic patients and 4477 controls served as the investigation sample. 3521 Bipolar patients and 3195 controls served as replication sample. A molecular pathway associated with the neuronal pruning activity was found to be enriched in subjects with Schizophrenia compared to controls. HLA-C and HLA-DRA had more SNPs associated with both Schizophrenia and Bipolar Disorder than expected by chance.

Original language	English
Journal	Psychiatry Research
Volume	228
Issue number	3
Pages (from-to)	945-9
Number of pages	5
ISSN	0165-1781
DOIs	https://doi.org/10.1016/j.psychres.2015.06.013
Publication status	Published - 30 Aug 2015
Externally published	Yes

Bibliographical note

Keywords

Adult
Bipolar Disorder/diagnosis
Female
Gene Regulatory Networks/genetics
Genetic Predisposition to Disease/epidemiology
Genetic Variation/genetics
Humans
Inflammation/diagnosis
Internationality
Male
Middle Aged
Neuronal Plasticity/genetics
Polymorphism, Single Nucleotide/genetics
Schizophrenia/diagnosis

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Calabrò, M., Marco, C., Drago, A., Antonio, D., Sidoti, A., Antonina, S., Serretti, A., Alessandro, S., Crisafulli, C., & Concetta, C. (2015). Genes involved in pruning and inflammation are enriched in a large mega-sample of patients affected by Schizophrenia and Bipolar Disorder and controls. Psychiatry Research, 228(3), 945-9. https://doi.org/10.1016/j.psychres.2015.06.013

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title = "Genes involved in pruning and inflammation are enriched in a large mega-sample of patients affected by Schizophrenia and Bipolar Disorder and controls",

abstract = "A molecular pathway analysis has been performed in order to complement previous genetic investigations on Schizophrenia. 4486 Schizophrenic patients and 4477 controls served as the investigation sample. 3521 Bipolar patients and 3195 controls served as replication sample. A molecular pathway associated with the neuronal pruning activity was found to be enriched in subjects with Schizophrenia compared to controls. HLA-C and HLA-DRA had more SNPs associated with both Schizophrenia and Bipolar Disorder than expected by chance. ",

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author = "Marco Calabr{\`o} and Calabr{\`o} Marco and Antonio Drago and Drago Antonio and Antonina Sidoti and Sidoti Antonina and Alessandro Serretti and Serretti Alessandro and Concetta Crisafulli and Crisafulli Concetta",

year = "2015",

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doi = "10.1016/j.psychres.2015.06.013",

language = "English",

volume = "228",

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Calabrò, M, Marco, C, Drago, A, Antonio, D, Sidoti, A, Antonina, S, Serretti, A, Alessandro, S, Crisafulli, C & Concetta, C 2015, 'Genes involved in pruning and inflammation are enriched in a large mega-sample of patients affected by Schizophrenia and Bipolar Disorder and controls', Psychiatry Research, vol. 228, no. 3, pp. 945-9. https://doi.org/10.1016/j.psychres.2015.06.013

TY - JOUR

T1 - Genes involved in pruning and inflammation are enriched in a large mega-sample of patients affected by Schizophrenia and Bipolar Disorder and controls

AU - Calabrò, Marco

AU - Marco, Calabrò

AU - Drago, Antonio

AU - Antonio, Drago

AU - Sidoti, Antonina

AU - Antonina, Sidoti

AU - Serretti, Alessandro

AU - Alessandro, Serretti

AU - Crisafulli, Concetta

AU - Concetta, Crisafulli

PY - 2015/8/30

Y1 - 2015/8/30

N2 - A molecular pathway analysis has been performed in order to complement previous genetic investigations on Schizophrenia. 4486 Schizophrenic patients and 4477 controls served as the investigation sample. 3521 Bipolar patients and 3195 controls served as replication sample. A molecular pathway associated with the neuronal pruning activity was found to be enriched in subjects with Schizophrenia compared to controls. HLA-C and HLA-DRA had more SNPs associated with both Schizophrenia and Bipolar Disorder than expected by chance.

AB - A molecular pathway analysis has been performed in order to complement previous genetic investigations on Schizophrenia. 4486 Schizophrenic patients and 4477 controls served as the investigation sample. 3521 Bipolar patients and 3195 controls served as replication sample. A molecular pathway associated with the neuronal pruning activity was found to be enriched in subjects with Schizophrenia compared to controls. HLA-C and HLA-DRA had more SNPs associated with both Schizophrenia and Bipolar Disorder than expected by chance.

KW - Adult

KW - Bipolar Disorder/diagnosis

KW - Female

KW - Gene Regulatory Networks/genetics

KW - Genetic Predisposition to Disease/epidemiology

KW - Genetic Variation/genetics

KW - Humans

KW - Inflammation/diagnosis

KW - Internationality

KW - Male

KW - Middle Aged

KW - Neuronal Plasticity/genetics

KW - Polymorphism, Single Nucleotide/genetics

KW - Schizophrenia/diagnosis

U2 - 10.1016/j.psychres.2015.06.013

DO - 10.1016/j.psychres.2015.06.013

M3 - Journal article

C2 - 26160200

SN - 0165-1781

VL - 228

SP - 945

EP - 949

JO - Psychiatry Research

JF - Psychiatry Research

IS - 3

ER -

Genes involved in pruning and inflammation are enriched in a large mega-sample of patients affected by Schizophrenia and Bipolar Disorder and controls

Abstract

Bibliographical note

Keywords

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