TY - JOUR
T1 - Genetic Association between ACE2 (rs2285666 and rs2074192) and TMPRSS2 (rs12329760 and rs2070788) Polymorphisms with Post-COVID Symptoms in Previously Hospitalized COVID-19 Survivors
AU - Fernández-de-las-Peñas, César
AU - Arendt-Nielsen, Lars
AU - Díaz-Gil, Gema
AU - Gómez-Esquer, Francisco
AU - Gil-Crujera, Antonio
AU - Gómez-Sánchez, Stella M.
AU - Ambite-Quesada, Silvia
AU - Palomar-Gallego, María A.
AU - Pellicer-Valero, Oscar J.
AU - Giordano, Rocco
PY - 2022/11
Y1 - 2022/11
N2 - The aim of the study was to identify the association between four selected COVID-19 polymorphisms of ACE2 and TMPRSS2 receptors genes with the presence of long-COVID symptomatology in COVID-19 survivors. These genes were selected as they associate with the entry of the SARS-CoV-2 virus into the cells, so polymorphisms could be important for the prognoses of long-COVID symptoms. Two hundred and ninety-three (n = 293, 49.5% female, mean age: 55.6 ± 12.9 years) individuals who had been previously hospitalized due to COVID-19 were included. Three potential genotypes of the following single nucleotide polymorphisms (SNPs) were obtained from non-stimulated saliva samples of participants: ACE2 (rs2285666), ACE2 (rs2074192), TMPRSS2 (rs12329760), TMPRSS2 (rs2070788). Participants were asked to self-report the presence of any post-COVID defined as a symptom that started no later than one month after SARS-CoV-2 acute infection and whether the symptom persisted at the time of the study. At the time of the study (mean: 17.8, SD: 5.2 months after hospital discharge), 87.7% patients reported at least one symptom. Fatigue (62.8%), pain (39.9%) or memory loss (32.1%) were the most prevalent post-COVID symptoms. Overall, no differences in long-COVID symptoms were dependent on ACE2 rs2285666, ACE2 rs2074192, TMPRSS2 rs12329760, or TMPRSS2 rs2070788 genotypes. The four SNPs assessed, albeit previously associated with COVID-19 severity, do not predispose for developing long-COVID symptoms in people who were previously hospitalized due to COVID-19 during the first wave of the pandemic.
AB - The aim of the study was to identify the association between four selected COVID-19 polymorphisms of ACE2 and TMPRSS2 receptors genes with the presence of long-COVID symptomatology in COVID-19 survivors. These genes were selected as they associate with the entry of the SARS-CoV-2 virus into the cells, so polymorphisms could be important for the prognoses of long-COVID symptoms. Two hundred and ninety-three (n = 293, 49.5% female, mean age: 55.6 ± 12.9 years) individuals who had been previously hospitalized due to COVID-19 were included. Three potential genotypes of the following single nucleotide polymorphisms (SNPs) were obtained from non-stimulated saliva samples of participants: ACE2 (rs2285666), ACE2 (rs2074192), TMPRSS2 (rs12329760), TMPRSS2 (rs2070788). Participants were asked to self-report the presence of any post-COVID defined as a symptom that started no later than one month after SARS-CoV-2 acute infection and whether the symptom persisted at the time of the study. At the time of the study (mean: 17.8, SD: 5.2 months after hospital discharge), 87.7% patients reported at least one symptom. Fatigue (62.8%), pain (39.9%) or memory loss (32.1%) were the most prevalent post-COVID symptoms. Overall, no differences in long-COVID symptoms were dependent on ACE2 rs2285666, ACE2 rs2074192, TMPRSS2 rs12329760, or TMPRSS2 rs2070788 genotypes. The four SNPs assessed, albeit previously associated with COVID-19 severity, do not predispose for developing long-COVID symptoms in people who were previously hospitalized due to COVID-19 during the first wave of the pandemic.
KW - ACE2
KW - Adult
KW - Aged
KW - Angiotensin-Converting Enzyme 2/genetics
KW - COVID-19/genetics
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Peptidyl-Dipeptidase A/genetics
KW - Polymorphism, Single Nucleotide
KW - SARS-CoV-2
KW - Serine Endopeptidases/genetics
KW - Survivors
KW - TMPRSS2
KW - long-covid
KW - post-covid
KW - single nucleotide polymorphism
KW - long-COVID
KW - post-COVID
UR - http://www.scopus.com/inward/record.url?scp=85141764776&partnerID=8YFLogxK
U2 - 10.3390/genes13111935
DO - 10.3390/genes13111935
M3 - Journal article
C2 - 36360172
SN - 2073-4425
VL - 13
JO - genes
JF - genes
IS - 11
M1 - 1935
ER -