Genetic risk scores link body fat distribution with specific cardiometabolic profiles

Mathilde Svendstrup; Camilla H Sandholt; Ehm Astrid Andersson Galijatovic; Allan Linneberg; Torben Jørgensen; Thorkild I A Sørensen; Oluf Pedersen; Niels Grarup; Henrik Vestergaard; Torben Hansen

doi:10.1002/oby.21473

Genetic risk scores link body fat distribution with specific cardiometabolic profiles

Mathilde Svendstrup, Camilla H Sandholt, Ehm Astrid Andersson Galijatovic, Allan Linneberg, Torben Jørgensen, Thorkild I A Sørensen, Oluf Pedersen, Niels Grarup, Henrik Vestergaard, Torben Hansen

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Abstract

OBJECTIVE: Forty-nine known single nucleotide polymorphisms (SNPs) associating with body mass index (BMI)-adjusted waist-hip-ratio (WHR) (WHRadjBMI) were recently suggested to cluster into three groups with different associations to cardiometabolic traits. Genetic risk scores of the clusters on the risk of incident diabetes and associations with detailed cardiometabolic phenotypes were tested.

METHODS: In a prospective study of 6,121 Inter99 individuals, the risk of incident diabetes using Cox proportional hazards regression was evaluated. Using linear regession, the associations between genetic risk scores and anthropometry and blood samples at fasting and during an oral glucose tolerance test were tested. Analyses were adjusted for age, sex, and BMI.

RESULTS: Cluster 1 associated with an increased risk of diabetes (HR = 1.05, P = 2.74 × 10(-) (4) ) and with a poor metabolic profile, including fasting serum triglyceride (β = 0.98% mmol/L, P = 3.33 × 10(-) (8) ) and Matsuda index (β = -0.74%, P = 1.29 × 10(-) (4) ). No similar associations for Clusters 2 and 3 were found. The three clusters showed different patterns of association with waist circumference, hip circumference, and height.

CONCLUSIONS: Our results suggest that the 49 WHRadjBMI-associated SNPs affect metabolic health differently depending on the cluster of SNPs. The clusters further associate differently with anthropometric measures.

Original language	English
Journal	Obesity
Volume	24
Issue number	8
Pages (from-to)	1778-1785
Number of pages	8
ISSN	1930-7381
DOIs	https://doi.org/10.1002/oby.21473
Publication status	Published - 2016
Externally published	Yes

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@article{1b086333040d480490041561b73bc5ee,

title = "Genetic risk scores link body fat distribution with specific cardiometabolic profiles",

abstract = "OBJECTIVE: Forty-nine known single nucleotide polymorphisms (SNPs) associating with body mass index (BMI)-adjusted waist-hip-ratio (WHR) (WHRadjBMI) were recently suggested to cluster into three groups with different associations to cardiometabolic traits. Genetic risk scores of the clusters on the risk of incident diabetes and associations with detailed cardiometabolic phenotypes were tested.METHODS: In a prospective study of 6,121 Inter99 individuals, the risk of incident diabetes using Cox proportional hazards regression was evaluated. Using linear regession, the associations between genetic risk scores and anthropometry and blood samples at fasting and during an oral glucose tolerance test were tested. Analyses were adjusted for age, sex, and BMI.RESULTS: Cluster 1 associated with an increased risk of diabetes (HR = 1.05, P = 2.74 × 10(-) (4) ) and with a poor metabolic profile, including fasting serum triglyceride (β = 0.98% mmol/L, P = 3.33 × 10(-) (8) ) and Matsuda index (β = -0.74%, P = 1.29 × 10(-) (4) ). No similar associations for Clusters 2 and 3 were found. The three clusters showed different patterns of association with waist circumference, hip circumference, and height.CONCLUSIONS: Our results suggest that the 49 WHRadjBMI-associated SNPs affect metabolic health differently depending on the cluster of SNPs. The clusters further associate differently with anthropometric measures.",

author = "Mathilde Svendstrup and Sandholt, {Camilla H} and {Andersson Galijatovic}, {Ehm Astrid} and Allan Linneberg and Torben J{\o}rgensen and S{\o}rensen, {Thorkild I A} and Oluf Pedersen and Niels Grarup and Henrik Vestergaard and Torben Hansen",

note = "{\textcopyright} 2016 The Obesity Society.",

year = "2016",

doi = "10.1002/oby.21473",

language = "English",

volume = "24",

pages = "1778--1785",

journal = "Obesity",

issn = "1930-7381",

publisher = "Wiley-Blackwell",

number = "8",

}

TY - JOUR

T1 - Genetic risk scores link body fat distribution with specific cardiometabolic profiles

AU - Svendstrup, Mathilde

AU - Sandholt, Camilla H

AU - Andersson Galijatovic, Ehm Astrid

AU - Linneberg, Allan

AU - Jørgensen, Torben

AU - Sørensen, Thorkild I A

AU - Pedersen, Oluf

AU - Grarup, Niels

AU - Vestergaard, Henrik

AU - Hansen, Torben

PY - 2016

Y1 - 2016

N2 - OBJECTIVE: Forty-nine known single nucleotide polymorphisms (SNPs) associating with body mass index (BMI)-adjusted waist-hip-ratio (WHR) (WHRadjBMI) were recently suggested to cluster into three groups with different associations to cardiometabolic traits. Genetic risk scores of the clusters on the risk of incident diabetes and associations with detailed cardiometabolic phenotypes were tested.METHODS: In a prospective study of 6,121 Inter99 individuals, the risk of incident diabetes using Cox proportional hazards regression was evaluated. Using linear regession, the associations between genetic risk scores and anthropometry and blood samples at fasting and during an oral glucose tolerance test were tested. Analyses were adjusted for age, sex, and BMI.RESULTS: Cluster 1 associated with an increased risk of diabetes (HR = 1.05, P = 2.74 × 10(-) (4) ) and with a poor metabolic profile, including fasting serum triglyceride (β = 0.98% mmol/L, P = 3.33 × 10(-) (8) ) and Matsuda index (β = -0.74%, P = 1.29 × 10(-) (4) ). No similar associations for Clusters 2 and 3 were found. The three clusters showed different patterns of association with waist circumference, hip circumference, and height.CONCLUSIONS: Our results suggest that the 49 WHRadjBMI-associated SNPs affect metabolic health differently depending on the cluster of SNPs. The clusters further associate differently with anthropometric measures.

AB - OBJECTIVE: Forty-nine known single nucleotide polymorphisms (SNPs) associating with body mass index (BMI)-adjusted waist-hip-ratio (WHR) (WHRadjBMI) were recently suggested to cluster into three groups with different associations to cardiometabolic traits. Genetic risk scores of the clusters on the risk of incident diabetes and associations with detailed cardiometabolic phenotypes were tested.METHODS: In a prospective study of 6,121 Inter99 individuals, the risk of incident diabetes using Cox proportional hazards regression was evaluated. Using linear regession, the associations between genetic risk scores and anthropometry and blood samples at fasting and during an oral glucose tolerance test were tested. Analyses were adjusted for age, sex, and BMI.RESULTS: Cluster 1 associated with an increased risk of diabetes (HR = 1.05, P = 2.74 × 10(-) (4) ) and with a poor metabolic profile, including fasting serum triglyceride (β = 0.98% mmol/L, P = 3.33 × 10(-) (8) ) and Matsuda index (β = -0.74%, P = 1.29 × 10(-) (4) ). No similar associations for Clusters 2 and 3 were found. The three clusters showed different patterns of association with waist circumference, hip circumference, and height.CONCLUSIONS: Our results suggest that the 49 WHRadjBMI-associated SNPs affect metabolic health differently depending on the cluster of SNPs. The clusters further associate differently with anthropometric measures.

U2 - 10.1002/oby.21473

DO - 10.1002/oby.21473

M3 - Journal article

C2 - 27311925

SN - 1930-7381

VL - 24

SP - 1778

EP - 1785

JO - Obesity

JF - Obesity

IS - 8

ER -

Genetic risk scores link body fat distribution with specific cardiometabolic profiles

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