Genetic susceptibility of the arterial wall is an important determinant of atherosclerosis in C57BL/6 and FVB/N mouse strains

Jeong Shim, Aase Handberg, Eva-Britt Caroline Östergren, Erling Falk, Jacob F Bentzon

Research output: Contribution to journalJournal articleResearchpeer-review

8 Citations (Scopus)

Abstract

How genetic variations among inbred mouse strains translate into differences in atherosclerosis susceptibility is of significant interest for the development of new therapeutic strategies. The objective of the present study was to examine whether genetically controlled arterial wall properties influence atherosclerosis susceptibility in FVB/N (FVB) and C57BL/6 (B6) apolipoprotein E knockout (apoE(-/-)) mouse strains.
Original languageEnglish
Volume31
Pages (from-to)1814-20
Number of pages7
DOIs
Publication statusPublished - 2011
Externally publishedYes

Keywords

  • Animals
  • Apolipoproteins E
  • Atherosclerosis
  • Carotid Artery, Common
  • Carotid Stenosis
  • Cholesterol
  • Female
  • Genetic Predisposition to Disease
  • Hybridization, Genetic
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred Strains
  • Mice, Knockout
  • Species Specificity
  • Transplantation, Homologous

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