TY - GEN
T1 - Genetics of healthy aging in Europe
T2 - The EU-integrated project GEHA (GEnetics of Healthy Aging)
AU - Franceschi, Claudio
AU - Bezrukov, Vladyslav
AU - Blanché, Hélène
AU - Bolund, Lars
AU - Christensen, Kaare
AU - De Benedictis, Giovanna
AU - Deiana, Luca
AU - Gonos, Efsthatios
AU - Hervonen, Antti
AU - Yang, Huanning
AU - Jeune, Bernard
AU - Kirkwood, Tom B.L.
AU - Kristensen, Peter
AU - Leon, Alberta
AU - Pelicci, Pier Giuseppe
AU - Peltonen, Leena
AU - Poulain, Michel
AU - Rea, Irene Maeve
AU - Remacle, José
AU - Robine, Jean Marie
AU - Schreiber, Stefan
AU - Sikora, Ewa
AU - Slagboom, Pieternella Eline
AU - Spazzafumo, Liana
AU - Stazi, Maria Antonietta
AU - Toussaint, Olivier
AU - Vaupel, James W.
PY - 2007/1/1
Y1 - 2007/1/1
N2 - The aim of the 5-year European Union (EU)-Integrated Project GEnetics of Healthy Aging (GEHA), constituted by 25 partners (24 from Europe plus the Beijing Genomics Institute from China), is to identify genes involved in healthy aging and longevity, which allow individuals to survive to advanced old age in good cognitive and physical function and in the absence of major age-related diseases. To achieve this aim a coherent, tightly integrated program of research that unites demographers, geriatricians, geneticists, genetic epidemiologists, molecular biologists, bioinfomaticians, and statisticians has been set up. The working plan is to: (a) collect DNA and information on the health status from an unprecedented number of long-lived 90+ sibpairs (n = 2650) and of younger ethnically matched controls (n = 2650) from 11 European countries; (b) perform a genome-wide linkage scannning in all the sibpairs (a total of 5300 individuals); this investigation will be followed by linkage disequilibrium mapping (LD mapping) of the candidate chromosomal regions; (c) study in cases (i.e., the 2650 probands of the sibpairs) and controls (2650 younger people), genomic regions (chromosome 4, D4S1564, chromosome 11, 11.p15.5) which were identified in previous studies as possible candidates to harbor longevity genes; (d) genotype all recruited subjects for apoE polymorphisms; and (e) genotype all recruited subjects for inherited aswell as epigenetic variability of the mitochondrial DNA (mtDNA). The genetic analysis will be performed by 9 high-throughput platforms, within the framework of centralized databases for phenotypic, genetic, and mtDNA data. Additional advanced approaches (bioinformatics, advanced statistics, mathematical modeling, functional genomics and proteomics, molecular biology, molecular genetics) are envisaged to identify the gene variant(s) of interest. The experimental design will also allow(a) to identify gender-specific genes involved in healthy aging and longevity in women and men stratified for ethnic and geographic origin and apoE genotype; (b) to perform a longitudinal survival study to assess the impact of the identified genetic loci on 90+ people mortality; and (c) to develop mathematical and statistical models capable of combining genetic data with demographic characteristics, health status, socioeconomic factors, lifestyle habits.
AB - The aim of the 5-year European Union (EU)-Integrated Project GEnetics of Healthy Aging (GEHA), constituted by 25 partners (24 from Europe plus the Beijing Genomics Institute from China), is to identify genes involved in healthy aging and longevity, which allow individuals to survive to advanced old age in good cognitive and physical function and in the absence of major age-related diseases. To achieve this aim a coherent, tightly integrated program of research that unites demographers, geriatricians, geneticists, genetic epidemiologists, molecular biologists, bioinfomaticians, and statisticians has been set up. The working plan is to: (a) collect DNA and information on the health status from an unprecedented number of long-lived 90+ sibpairs (n = 2650) and of younger ethnically matched controls (n = 2650) from 11 European countries; (b) perform a genome-wide linkage scannning in all the sibpairs (a total of 5300 individuals); this investigation will be followed by linkage disequilibrium mapping (LD mapping) of the candidate chromosomal regions; (c) study in cases (i.e., the 2650 probands of the sibpairs) and controls (2650 younger people), genomic regions (chromosome 4, D4S1564, chromosome 11, 11.p15.5) which were identified in previous studies as possible candidates to harbor longevity genes; (d) genotype all recruited subjects for apoE polymorphisms; and (e) genotype all recruited subjects for inherited aswell as epigenetic variability of the mitochondrial DNA (mtDNA). The genetic analysis will be performed by 9 high-throughput platforms, within the framework of centralized databases for phenotypic, genetic, and mtDNA data. Additional advanced approaches (bioinformatics, advanced statistics, mathematical modeling, functional genomics and proteomics, molecular biology, molecular genetics) are envisaged to identify the gene variant(s) of interest. The experimental design will also allow(a) to identify gender-specific genes involved in healthy aging and longevity in women and men stratified for ethnic and geographic origin and apoE genotype; (b) to perform a longitudinal survival study to assess the impact of the identified genetic loci on 90+ people mortality; and (c) to develop mathematical and statistical models capable of combining genetic data with demographic characteristics, health status, socioeconomic factors, lifestyle habits.
KW - Aging
KW - Centenarians
KW - Genetics
KW - Longevity
KW - Mitochondrial DNA
UR - http://www.scopus.com/inward/record.url?scp=34249744331&partnerID=8YFLogxK
U2 - 10.1196/annals.1395.003
DO - 10.1196/annals.1395.003
M3 - Article in proceeding
C2 - 17460163
AN - SCOPUS:34249744331
SN - 1573316792
SN - 9781573316798
T3 - Annals of the New York Academy of Sciences
SP - 21
EP - 45
BT - Biogerontology
PB - Wiley-Blackwell
ER -