TY - JOUR
T1 - Geographical and ecological analyses of multiple myeloma in Denmark
T2 - Identification of potential hotspot areas and impact of urbanisation
AU - Bertelsen, Lise Dueholm
AU - Børty Nielsen, Lars
AU - Christensen, Heidi Søgaard
AU - Bøgsted, Martin
AU - Gregersen, Henrik
AU - Pedersen, Robert Schou
AU - Klostergaard, Anja
AU - Schnack, Brian Iversen
AU - Pedersen, Per Trøllund
AU - Abildgaard, Niels
AU - Hermansen, Emil
AU - Vangsted, Annette Juul
AU - Severinsen, Marianne Tang
N1 - © 2022 The Authors. European Journal of Haematology published by John Wiley & Sons Ltd.
PY - 2023/3
Y1 - 2023/3
N2 - BACKGROUND: The aetiology of multiple myeloma (MM) is unknown but various environmental exposures are suspected as risk factors. We present the first paper analysing the geographical distribution of MM in Denmark at the municipal level to investigate variations that could be explained by environmental exposures.METHODS: Patients diagnosed with MM in Denmark during 2005-2020 were identified from nationwide registries and grouped into the 98 Danish municipalities based on residence. The age- and sex-standardised incidence rate (SIR) of each municipality was compared to the national incidence in a funnel plot with 95% control limits. Differences in SIRs of rural, suburban, and urban areas were evaluated with incidence rate ratios.RESULTS: In total, 5243 MM patients were included. Overall, we found a heterogeneous geographical distribution of MM and a potential hotspot in southern Denmark. This hotspot contains three municipalities with SIRs above the 95% control limit assuming considerably higher rate of MM compared to the national incidence rate. A significant higher SIR was found in rural areas compared to urban areas.CONCLUSION: The geographical distribution of MM in Denmark indicates that the risk of developing MM depends on place of residence probably due to environmental factors.
AB - BACKGROUND: The aetiology of multiple myeloma (MM) is unknown but various environmental exposures are suspected as risk factors. We present the first paper analysing the geographical distribution of MM in Denmark at the municipal level to investigate variations that could be explained by environmental exposures.METHODS: Patients diagnosed with MM in Denmark during 2005-2020 were identified from nationwide registries and grouped into the 98 Danish municipalities based on residence. The age- and sex-standardised incidence rate (SIR) of each municipality was compared to the national incidence in a funnel plot with 95% control limits. Differences in SIRs of rural, suburban, and urban areas were evaluated with incidence rate ratios.RESULTS: In total, 5243 MM patients were included. Overall, we found a heterogeneous geographical distribution of MM and a potential hotspot in southern Denmark. This hotspot contains three municipalities with SIRs above the 95% control limit assuming considerably higher rate of MM compared to the national incidence rate. A significant higher SIR was found in rural areas compared to urban areas.CONCLUSION: The geographical distribution of MM in Denmark indicates that the risk of developing MM depends on place of residence probably due to environmental factors.
KW - disease hotspot
KW - epidemiology
KW - incidence
KW - multiple myeloma
KW - spatial analysis
UR - http://www.scopus.com/inward/record.url?scp=85143895316&partnerID=8YFLogxK
U2 - 10.1111/ejh.13904
DO - 10.1111/ejh.13904
M3 - Journal article
C2 - 36413106
SN - 0902-4441
VL - 110
SP - 289
EP - 295
JO - European Journal of Haematology
JF - European Journal of Haematology
IS - 3
ER -