TY - JOUR
T1 - Getting controls under control
T2 - the time is now for immunohistochemistry
AU - Torlakovic, Emina Emilia
AU - Nielsen, Søren
AU - Vyberg, Mogens
AU - Taylor, Clive R
N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
PY - 2015
Y1 - 2015
N2 - For several decades, immunohistochemistry (IHC), more specifically diagnostic IHC (dIHC), has been considered an art rather than a laboratory test. There was no clarity about what test performance characteristics are relevant to dIHC, test performance characteristics were not fully defined for dIHC and partly as a consequence of that, there were no standardised controls or reference standards. Herein, we discuss the role of standardisation of external controls for test performance characteristics and the role of standardised controls and reference standards for overall standardisation of IHC.
AB - For several decades, immunohistochemistry (IHC), more specifically diagnostic IHC (dIHC), has been considered an art rather than a laboratory test. There was no clarity about what test performance characteristics are relevant to dIHC, test performance characteristics were not fully defined for dIHC and partly as a consequence of that, there were no standardised controls or reference standards. Herein, we discuss the role of standardisation of external controls for test performance characteristics and the role of standardised controls and reference standards for overall standardisation of IHC.
U2 - 10.1136/jclinpath-2014-202705
DO - 10.1136/jclinpath-2014-202705
M3 - Review article
C2 - 26286753
SN - 0021-9746
VL - 68
SP - 879
EP - 882
JO - Journal of Clinical Pathology
JF - Journal of Clinical Pathology
IS - 11
ER -