Abstract
AIMS: This study investigated brain structure in patients of type 1 diabetes with diabetic peripheral neuropathy (DPN) and type 1 diabetes with neuropathic pain and the associations to clinical, peripheral, and cognitive measurements.
METHODS: Sixty individuals with type 1 diabetes and 20 healthy controls were included in the study. Nineteen individuals with type 1 diabetes and neuropathic pain, 19 with type 1 diabetes and DPN, 18 with type 1 diabetes without DPN, and 20 healthy controls were included in the brain analyses. We utilized structural brain magnetic resonance imaging to investigate total and regional gray matter volume.
RESULTS: Significant lower gray matter volume was found in type 1 diabetes with neuropathic pain and in type 1 diabetes without DPN compared to healthy controls (p=0.024 and p=0.019, respectively). Lower insula volume was observed in all three diabetes groups (all p≤0.050). Thalamus and hippocampus volume was lower in type 1 diabetes with neuropathic pain, cerebellum volume was lower in type 1 diabetes with DPN, and somatosensory cortex volume was lower in type 1 diabetes without DPN (all p≤0.018). Attenuated memory was associated with lower gray matter volume in type 1 diabetes with DPN. No associations were found between gray matter volume and clinical/peripheral measurements.
CONCLUSION: We demonstrated lower gray matter volume in individuals with type 1 diabetes regardless of the presence of DPN and neuropathic pain. Hence, central gray matter alteration was not associated with peripheral alterations.
Original language | English |
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Journal | Experimental and Clinical Endocrinology and Diabetes |
Volume | 130 |
Issue number | 11 |
Pages (from-to) | 730-739 |
Number of pages | 10 |
ISSN | 0947-7349 |
DOIs | |
Publication status | Published - Nov 2022 |
Bibliographical note
This work was partly supported by the Augustinus Fonden, Denmark (grant no.19-1302). The funding source did not influence the study.Thieme. All rights reserved.
Keywords
- Brain structure
- Brain volume alterations
- Diabetes
- Diabetic peripheral neuropathy
- Magnetic resonance imaging