Gut Microbiota in Bone Health and Diabetes

Julie Kristine Knudsen*, Peter Leutscher, Suzette Sørensen

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

26 Citations (Scopus)

Abstract

Purpose of Review: Patients with diabetes mellitus (DM) are at increased risk of developing osteopathogenesis and skeletal fragility. The role of the gut microbiota in both DM and osteopathy is not fully explored and may be involved in the pathology of both diseases. Recent Findings: Gut microbiota alterations have been observed in DM and osteopathogenic disorders as compared with healthy controls, such as significantly lower abundance of Prevotella and higher abundance of Lactobacillus, with a diminished bacterial diversity. Other overlapping gastro-intestinal features include the loss of intestinal barrier function with translocation of bacterial metabolites to the blood stream, induction of immunological deficits and changes in hormonal and endocrinal signalling, which may lead to the development of diabetic osteopathy. Summary: Signalling pathways involved in both DM and osteopathy are affected by gut bacteria and their metabolites. Future studies should focus on gut microbiota involvement in both diseases.

Original languageEnglish
JournalCurrent Osteoporosis Reports
Volume19
Issue number4
Pages (from-to)462-479
Number of pages18
ISSN1544-1873
DOIs
Publication statusPublished - Aug 2021

Bibliographical note

Correction published:
Knudsen, J.K., Leutscher, P. & Sørensen, S. Correction to: Gut Microbiota in Bone Health and Diabetes. Curr Osteoporos Rep 19, 480 (2021). https://doi-org.auh.aub.aau.dk/10.1007/s11914-021-00694-8.

"The original version of this article unfortunately contained
mistakes. The reference citations did not match with the reference list.
The original article has been corrected."

Keywords

  • Gut microbiota
  • Osteopathy
  • Osteoporosis
  • Type 1 diabetes
  • Type 2 diabetes

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