Hepatitis B and C in the adult population of Bissau, Guinea-Bissau: a cross-sectional survey

Bo Langhoff Hønge; Jens Steen Olesen; Mads Mose Jensen; Sanne Jespersen; Zacarias José da Silva; Amabélia Rodrigues; Alex Lund Laursen; Christian Wejse; Henrik Krarup; Peter Aaby; Christian Erikstrup

doi:10.1111/tmi.13335

Hepatitis B and C in the adult population of Bissau, Guinea-Bissau: a cross-sectional survey

Bo Langhoff Hønge, Jens Steen Olesen, Mads Mose Jensen, Sanne Jespersen, Zacarias José da Silva, Amabélia Rodrigues, Alex Lund Laursen, Christian Wejse, Henrik Krarup, Peter Aaby, Christian Erikstrup

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Abstract

OBJECTIVE: Hepatitis B virus (HBV) and hepatitis C virus (HCV) are prevalent in West Africa. To address the WHO 2030 goals of a 90% reduction in incidence and a 65% reduction in mortality for both infections, we assessed the prevalence of HBV and HCV from surveys in the general population.

METHODS: Participants in this cross-sectional survey were included from randomly selected houses in a demographic surveillance site in Bissau, Guinea-Bissau. Participants were interviewed and had a blood sample drawn for viral analyses (HBsAg, anti-HBs, anti-HBc, anti-HCV and HCV RNA). Risk factors of HBV and HCV infection were determined by binomial regression adjusted for sex and age.

RESULTS: A total of 2715 participants were included in this study. The overall HBsAg prevalence was 18.7% (95% CI: 17.3-20.2%). HBsAg was associated with male sex (adjusted risk ratio (aRR): 1.64), and prevalence decreased with age >34 years. HBV exposure was found in 91.9% of participants. Although 72.6% of individuals without sexual debut had been exposed to HBV, ever engaging in a sexual relationship was associated with higher risk of HBV exposure (aRR 1.18). The anti-HCV prevalence was 0.5% (95% CI: 0.3-0.9%), and 78.6% of those had detectable HCV RNA. Risk factors for anti-HCV sero-positivity were age above 55 (aRR 10.60), a history of blood transfusion (aRR 5.07) and being in a polygamous marriage (aRR 3.52).

CONCLUSION: In Guinea-Bissau initiatives to implement treatment and widespread testing are needed to reach the WHO 2030 goals.

Original language	English
Journal	Tropical Medicine & International Health
Volume	25
Issue number	2
Pages (from-to)	255-263
Number of pages	9
ISSN	1360-2276
DOIs	https://doi.org/10.1111/tmi.13335
Publication status	Published - Feb 2020

Keywords

Guinea-Bissau
HIV
HIV-2
HTLV
hepatitis B
hepatitis C

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Hønge, B. L., Olesen, J. S., Jensen, M. M., Jespersen, S., da Silva, Z. J., Rodrigues, A., Laursen, A. L., Wejse, C., Krarup, H., Aaby, P., & Erikstrup, C. (2020). Hepatitis B and C in the adult population of Bissau, Guinea-Bissau: a cross-sectional survey. Tropical Medicine & International Health, 25(2), 255-263. Advance online publication. https://doi.org/10.1111/tmi.13335

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title = "Hepatitis B and C in the adult population of Bissau, Guinea-Bissau: a cross-sectional survey",

abstract = "OBJECTIVE: Hepatitis B virus (HBV) and hepatitis C virus (HCV) are prevalent in West Africa. To address the WHO 2030 goals of a 90% reduction in incidence and a 65% reduction in mortality for both infections, we assessed the prevalence of HBV and HCV from surveys in the general population.METHODS: Participants in this cross-sectional survey were included from randomly selected houses in a demographic surveillance site in Bissau, Guinea-Bissau. Participants were interviewed and had a blood sample drawn for viral analyses (HBsAg, anti-HBs, anti-HBc, anti-HCV and HCV RNA). Risk factors of HBV and HCV infection were determined by binomial regression adjusted for sex and age.RESULTS: A total of 2715 participants were included in this study. The overall HBsAg prevalence was 18.7% (95% CI: 17.3-20.2%). HBsAg was associated with male sex (adjusted risk ratio (aRR): 1.64), and prevalence decreased with age >34 years. HBV exposure was found in 91.9% of participants. Although 72.6% of individuals without sexual debut had been exposed to HBV, ever engaging in a sexual relationship was associated with higher risk of HBV exposure (aRR 1.18). The anti-HCV prevalence was 0.5% (95% CI: 0.3-0.9%), and 78.6% of those had detectable HCV RNA. Risk factors for anti-HCV sero-positivity were age above 55 (aRR 10.60), a history of blood transfusion (aRR 5.07) and being in a polygamous marriage (aRR 3.52).CONCLUSION: In Guinea-Bissau initiatives to implement treatment and widespread testing are needed to reach the WHO 2030 goals.",

keywords = "Guinea-Bissau, HIV, HIV-2, HTLV, hepatitis B, hepatitis C",

author = "H{\o}nge, {Bo Langhoff} and Olesen, {Jens Steen} and Jensen, {Mads Mose} and Sanne Jespersen and {da Silva}, {Zacarias Jos{\'e}} and Amab{\'e}lia Rodrigues and Laursen, {Alex Lund} and Christian Wejse and Henrik Krarup and Peter Aaby and Christian Erikstrup",

note = "{\textcopyright} 2019 John Wiley & Sons Ltd.",

year = "2020",

month = feb,

doi = "10.1111/tmi.13335",

language = "English",

volume = "25",

pages = "255--263",

journal = "Tropical Medicine & International Health",

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TY - JOUR

T1 - Hepatitis B and C in the adult population of Bissau, Guinea-Bissau

T2 - a cross-sectional survey

AU - Hønge, Bo Langhoff

AU - Olesen, Jens Steen

AU - Jensen, Mads Mose

AU - Jespersen, Sanne

AU - da Silva, Zacarias José

AU - Rodrigues, Amabélia

AU - Laursen, Alex Lund

AU - Wejse, Christian

AU - Krarup, Henrik

AU - Aaby, Peter

AU - Erikstrup, Christian

PY - 2020/2

Y1 - 2020/2

N2 - OBJECTIVE: Hepatitis B virus (HBV) and hepatitis C virus (HCV) are prevalent in West Africa. To address the WHO 2030 goals of a 90% reduction in incidence and a 65% reduction in mortality for both infections, we assessed the prevalence of HBV and HCV from surveys in the general population.METHODS: Participants in this cross-sectional survey were included from randomly selected houses in a demographic surveillance site in Bissau, Guinea-Bissau. Participants were interviewed and had a blood sample drawn for viral analyses (HBsAg, anti-HBs, anti-HBc, anti-HCV and HCV RNA). Risk factors of HBV and HCV infection were determined by binomial regression adjusted for sex and age.RESULTS: A total of 2715 participants were included in this study. The overall HBsAg prevalence was 18.7% (95% CI: 17.3-20.2%). HBsAg was associated with male sex (adjusted risk ratio (aRR): 1.64), and prevalence decreased with age >34 years. HBV exposure was found in 91.9% of participants. Although 72.6% of individuals without sexual debut had been exposed to HBV, ever engaging in a sexual relationship was associated with higher risk of HBV exposure (aRR 1.18). The anti-HCV prevalence was 0.5% (95% CI: 0.3-0.9%), and 78.6% of those had detectable HCV RNA. Risk factors for anti-HCV sero-positivity were age above 55 (aRR 10.60), a history of blood transfusion (aRR 5.07) and being in a polygamous marriage (aRR 3.52).CONCLUSION: In Guinea-Bissau initiatives to implement treatment and widespread testing are needed to reach the WHO 2030 goals.

AB - OBJECTIVE: Hepatitis B virus (HBV) and hepatitis C virus (HCV) are prevalent in West Africa. To address the WHO 2030 goals of a 90% reduction in incidence and a 65% reduction in mortality for both infections, we assessed the prevalence of HBV and HCV from surveys in the general population.METHODS: Participants in this cross-sectional survey were included from randomly selected houses in a demographic surveillance site in Bissau, Guinea-Bissau. Participants were interviewed and had a blood sample drawn for viral analyses (HBsAg, anti-HBs, anti-HBc, anti-HCV and HCV RNA). Risk factors of HBV and HCV infection were determined by binomial regression adjusted for sex and age.RESULTS: A total of 2715 participants were included in this study. The overall HBsAg prevalence was 18.7% (95% CI: 17.3-20.2%). HBsAg was associated with male sex (adjusted risk ratio (aRR): 1.64), and prevalence decreased with age >34 years. HBV exposure was found in 91.9% of participants. Although 72.6% of individuals without sexual debut had been exposed to HBV, ever engaging in a sexual relationship was associated with higher risk of HBV exposure (aRR 1.18). The anti-HCV prevalence was 0.5% (95% CI: 0.3-0.9%), and 78.6% of those had detectable HCV RNA. Risk factors for anti-HCV sero-positivity were age above 55 (aRR 10.60), a history of blood transfusion (aRR 5.07) and being in a polygamous marriage (aRR 3.52).CONCLUSION: In Guinea-Bissau initiatives to implement treatment and widespread testing are needed to reach the WHO 2030 goals.

KW - Guinea-Bissau

KW - HIV

KW - HIV-2

KW - HTLV

KW - hepatitis B

KW - hepatitis C

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U2 - 10.1111/tmi.13335

DO - 10.1111/tmi.13335

M3 - Journal article

C2 - 31746078

SN - 1360-2276

VL - 25

SP - 255

EP - 263

JO - Tropical Medicine & International Health

JF - Tropical Medicine & International Health

IS - 2

ER -

Hepatitis B and C in the adult population of Bissau, Guinea-Bissau: a cross-sectional survey

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