High yield from repeated testing for tuberculosis among high-risk citizens in Denmark

Nina Breinholt Staerke; Torben Smidt-Hansen; Leni Oldenborg; Torben Tranborg Jensen; Ulla Møller Weinreich; Shakil Shakar; Christian Wejse; Ole Hilberg; Andreas Fløe

doi:10.1016/j.ijid.2020.10.076

High yield from repeated testing for tuberculosis among high-risk citizens in Denmark

Nina Breinholt Staerke, Torben Smidt-Hansen, Leni Oldenborg, Torben Tranborg Jensen, Ulla Møller Weinreich, Shakil Shakar, Christian Wejse, Ole Hilberg, Andreas Fløe

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

BACKGROUND: Screening for TB (tuberculosis) among socially marginalized citizens has been implemented in many urban areas in countries with a low incidence of TB, including Denmark. This study aims to describe the findings of the screening programs for TB and latent tuberculosis (LTBI) used in the western part of Denmark in the period 2014-2019.

METHODS: Data was collected retrospectively on test results from interferon-gamma release assays (IGRA), spot sputum tests and chest X-rays performed as part of TB and LTBI screening among 1024 socially marginalized citizens in urban areas of western Denmark in 2014-2019.

RESULTS: The overall TB incidence was 2148/100.000 and number needed to screen to find one TB case was 39. The incidence of LTBI in the group screened using IGRA was 17.500/100.000. TB incidence when using spot sputum test was 2.5, while TB incidence when using IGRA as the primary screening test was 2.7. In total, 38.9% of TB diagnoses were obtained after the second or third round of screening.

CONCLUSION: We demonstrated a high incidence of TB and LTBI among socially marginalized citizens in Denmark. Screening with spot sputum testing and IGRA generated comparable results in diagnosing TB in this setting.

Original language	English
Journal	International Journal of Infectious Diseases
Volume	102
Pages (from-to)	352-356
Number of pages	5
ISSN	1201-9712
DOIs	https://doi.org/10.1016/j.ijid.2020.10.076
Publication status	Published - Jan 2021

Keywords

Active case finding
Screening
Latent tuberculosis infection
Homeless
Socially marginalized

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10.1016/j.ijid.2020.10.076Licence: CC BY-NC-ND 4.0

Staerke et al (2021) High yield from repeated testing for tuberculosis among high-risk citizens in DenmarkFinal published version, 454 KBLicence: CC BY-NC-ND 4.0

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@article{3d85323c4a6a48c4a6921d015573bd90,

title = "High yield from repeated testing for tuberculosis among high-risk citizens in Denmark",

abstract = "BACKGROUND: Screening for TB (tuberculosis) among socially marginalized citizens has been implemented in many urban areas in countries with a low incidence of TB, including Denmark. This study aims to describe the findings of the screening programs for TB and latent tuberculosis (LTBI) used in the western part of Denmark in the period 2014-2019.METHODS: Data was collected retrospectively on test results from interferon-gamma release assays (IGRA), spot sputum tests and chest X-rays performed as part of TB and LTBI screening among 1024 socially marginalized citizens in urban areas of western Denmark in 2014-2019.RESULTS: The overall TB incidence was 2148/100.000 and number needed to screen to find one TB case was 39. The incidence of LTBI in the group screened using IGRA was 17.500/100.000. TB incidence when using spot sputum test was 2.5, while TB incidence when using IGRA as the primary screening test was 2.7. In total, 38.9% of TB diagnoses were obtained after the second or third round of screening.CONCLUSION: We demonstrated a high incidence of TB and LTBI among socially marginalized citizens in Denmark. Screening with spot sputum testing and IGRA generated comparable results in diagnosing TB in this setting.",

keywords = "Active case finding, Screening, Latent tuberculosis infection, Homeless, Socially marginalized",

author = "Staerke, {Nina Breinholt} and Torben Smidt-Hansen and Leni Oldenborg and Jensen, {Torben Tranborg} and Weinreich, {Ulla M{\o}ller} and Shakil Shakar and Christian Wejse and Ole Hilberg and Andreas Fl{\o}e",

year = "2021",

month = jan,

doi = "10.1016/j.ijid.2020.10.076",

language = "English",

volume = "102",

pages = "352--356",

journal = "International Journal of Infectious Diseases",

issn = "1201-9712",

publisher = "Pergamon Press",

}

TY - JOUR

T1 - High yield from repeated testing for tuberculosis among high-risk citizens in Denmark

AU - Staerke, Nina Breinholt

AU - Smidt-Hansen, Torben

AU - Oldenborg, Leni

AU - Jensen, Torben Tranborg

AU - Weinreich, Ulla Møller

AU - Shakar, Shakil

AU - Wejse, Christian

AU - Hilberg, Ole

AU - Fløe, Andreas

PY - 2021/1

Y1 - 2021/1

N2 - BACKGROUND: Screening for TB (tuberculosis) among socially marginalized citizens has been implemented in many urban areas in countries with a low incidence of TB, including Denmark. This study aims to describe the findings of the screening programs for TB and latent tuberculosis (LTBI) used in the western part of Denmark in the period 2014-2019.METHODS: Data was collected retrospectively on test results from interferon-gamma release assays (IGRA), spot sputum tests and chest X-rays performed as part of TB and LTBI screening among 1024 socially marginalized citizens in urban areas of western Denmark in 2014-2019.RESULTS: The overall TB incidence was 2148/100.000 and number needed to screen to find one TB case was 39. The incidence of LTBI in the group screened using IGRA was 17.500/100.000. TB incidence when using spot sputum test was 2.5, while TB incidence when using IGRA as the primary screening test was 2.7. In total, 38.9% of TB diagnoses were obtained after the second or third round of screening.CONCLUSION: We demonstrated a high incidence of TB and LTBI among socially marginalized citizens in Denmark. Screening with spot sputum testing and IGRA generated comparable results in diagnosing TB in this setting.

AB - BACKGROUND: Screening for TB (tuberculosis) among socially marginalized citizens has been implemented in many urban areas in countries with a low incidence of TB, including Denmark. This study aims to describe the findings of the screening programs for TB and latent tuberculosis (LTBI) used in the western part of Denmark in the period 2014-2019.METHODS: Data was collected retrospectively on test results from interferon-gamma release assays (IGRA), spot sputum tests and chest X-rays performed as part of TB and LTBI screening among 1024 socially marginalized citizens in urban areas of western Denmark in 2014-2019.RESULTS: The overall TB incidence was 2148/100.000 and number needed to screen to find one TB case was 39. The incidence of LTBI in the group screened using IGRA was 17.500/100.000. TB incidence when using spot sputum test was 2.5, while TB incidence when using IGRA as the primary screening test was 2.7. In total, 38.9% of TB diagnoses were obtained after the second or third round of screening.CONCLUSION: We demonstrated a high incidence of TB and LTBI among socially marginalized citizens in Denmark. Screening with spot sputum testing and IGRA generated comparable results in diagnosing TB in this setting.

KW - Active case finding

KW - Screening

KW - Latent tuberculosis infection

KW - Homeless

KW - Socially marginalized

U2 - 10.1016/j.ijid.2020.10.076

DO - 10.1016/j.ijid.2020.10.076

M3 - Journal article

C2 - 33130208

SN - 1201-9712

VL - 102

SP - 352

EP - 356

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

ER -

High yield from repeated testing for tuberculosis among high-risk citizens in Denmark

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