Human B-blast specific target determinants in CML: a family study

H E Johnsen; J Mossin; M Madsen; T Kristensen; F Kissmeyer-Nielsen

Human B-blast specific target determinants in CML: a family study

H E Johnsen, J Mossin, M Madsen, T Kristensen, F Kissmeyer-Nielsen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Human B blast specific target determinants, selectively identified on PWM stimulated purified B lymphoblasts by in vitro generated CTLs, have previously been studied in the population and showed association to and inclusion of HLA-DR geneproducts. This report indicates that B blast target determinants are products of genes which in a codominant mendelain way segregate with the HLA haplotypes in 4 selected families. Furthermore tests of families with HLA-B/D, DR and HLA-D, DR/GLO recombinations show that human B blast specific target determinants are coded from loci (locus) in the HLA-D region, between HLA-B and GLO.

Original language	English
Journal	HLA
Volume	19
Issue number	3
Pages (from-to)	222-9
Number of pages	8
ISSN	2059-2302
Publication status	Published - Mar 1982
Externally published	Yes

Keywords

B-Lymphocytes
Cytotoxicity Tests, Immunologic
HLA Antigens
Haploidy
Humans
Lymphocyte Activation
Protein Biosynthesis
T-Lymphocytes

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title = "Human B-blast specific target determinants in CML: a family study",

abstract = "Human B blast specific target determinants, selectively identified on PWM stimulated purified B lymphoblasts by in vitro generated CTLs, have previously been studied in the population and showed association to and inclusion of HLA-DR geneproducts. This report indicates that B blast target determinants are products of genes which in a codominant mendelain way segregate with the HLA haplotypes in 4 selected families. Furthermore tests of families with HLA-B/D, DR and HLA-D, DR/GLO recombinations show that human B blast specific target determinants are coded from loci (locus) in the HLA-D region, between HLA-B and GLO.",

keywords = "B-Lymphocytes, Cytotoxicity Tests, Immunologic, HLA Antigens, Haploidy, Humans, Lymphocyte Activation, Protein Biosynthesis, T-Lymphocytes",

author = "Johnsen, {H E} and J Mossin and M Madsen and T Kristensen and F Kissmeyer-Nielsen",

year = "1982",

month = mar,

language = "English",

volume = "19",

pages = "222--9",

journal = "HLA",

issn = "2059-2302",

publisher = "Wiley",

number = "3",

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TY - JOUR

T1 - Human B-blast specific target determinants in CML

T2 - a family study

AU - Johnsen, H E

AU - Mossin, J

AU - Madsen, M

AU - Kristensen, T

AU - Kissmeyer-Nielsen, F

PY - 1982/3

Y1 - 1982/3

N2 - Human B blast specific target determinants, selectively identified on PWM stimulated purified B lymphoblasts by in vitro generated CTLs, have previously been studied in the population and showed association to and inclusion of HLA-DR geneproducts. This report indicates that B blast target determinants are products of genes which in a codominant mendelain way segregate with the HLA haplotypes in 4 selected families. Furthermore tests of families with HLA-B/D, DR and HLA-D, DR/GLO recombinations show that human B blast specific target determinants are coded from loci (locus) in the HLA-D region, between HLA-B and GLO.

AB - Human B blast specific target determinants, selectively identified on PWM stimulated purified B lymphoblasts by in vitro generated CTLs, have previously been studied in the population and showed association to and inclusion of HLA-DR geneproducts. This report indicates that B blast target determinants are products of genes which in a codominant mendelain way segregate with the HLA haplotypes in 4 selected families. Furthermore tests of families with HLA-B/D, DR and HLA-D, DR/GLO recombinations show that human B blast specific target determinants are coded from loci (locus) in the HLA-D region, between HLA-B and GLO.

KW - B-Lymphocytes

KW - Cytotoxicity Tests, Immunologic

KW - HLA Antigens

KW - Haploidy

KW - Humans

KW - Lymphocyte Activation

KW - Protein Biosynthesis

KW - T-Lymphocytes

M3 - Journal article

C2 - 6979814

SN - 2059-2302

VL - 19

SP - 222

EP - 229

JO - HLA

JF - HLA

IS - 3

ER -

Human B-blast specific target determinants in CML: a family study

Abstract

Keywords

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