Abstract
The B blast specific target determinant phenotype defined by cytotoxic lymphocytes and the HLA-DR phenotype was tested for correlation in two panel studies. First, CTL reagents with B blast specificity were selected from CTLs educated between HLA-A, B, (C) identical unrelated donors giving no cytotoxicity with specific T blasts, resulting in free selection of panel B blasts used as targets. Second, CTLs educated between HLA non-identical unrelated donors giving cytotoxicity against specific T as well a B blast targets could be seen with negative reactions against T blasts but positive reactions against B blasts of selected panel members giving, in this set up, a free selection of donors cocultured for education of CTLs. These panel studies showed that HLA-DR associated B blast specific target determinants can be identified by CTLs, indicating that the HLA system codes for these determinants either through gene products of a locus closely linked to or identical with the HLA-DR locus.
Original language | English |
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Journal | HLA |
Volume | 15 |
Issue number | 2 |
Pages (from-to) | 199-209 |
Number of pages | 11 |
ISSN | 2059-2302 |
Publication status | Published - Feb 1980 |
Externally published | Yes |
Keywords
- B-Lymphocytes
- HLA-A Antigens
- HLA-B Antigens
- HLA-C Antigens
- HLA-DR Antigens
- Humans
- Immunity, Cellular
- Immunologic Memory
- T-Lymphocytes, Cytotoxic