Hyperhidrosis and the risk of being treated for skin infections

Mattias A. S. Henning; Kristina S. Ibler; Sisse R. Ostrowski; Christian Erikstrup; Kaspar R. Nielsen; Mie T. Bruun; Henrik Hjalgrim; Henrik Ullum; Maria Didriksen; Khoa M. Dinh; Klaus Rostgaard; Ole B. Pedersen; Gregor B. Jemec

doi:10.1080/09546634.2021.1944971

Hyperhidrosis and the risk of being treated for skin infections

Mattias A. S. Henning^*, Kristina S. Ibler, Sisse R. Ostrowski, Christian Erikstrup, Kaspar R. Nielsen, Mie T. Bruun, Henrik Hjalgrim, Henrik Ullum, Maria Didriksen, Khoa M. Dinh, Klaus Rostgaard, Ole B. Pedersen, Gregor B. Jemec

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Abstract

BACKGROUND: A few studies have described an increased prevalence of skin infections in individuals with hyperhidrosis compared to others. However, it remains uncertain whether hyperhidrosis is an independent risk factor for skin infections.

OBJECTIVE: To compare the risk of skin infections in individuals with and without hyperhidrosis.

METHODS: In this retrospective cohort study, data on hyperhidrosis were collected from the Danish Blood Donor Study. Blood donors included in 2010-2019 were followed from inclusion until December 2019. Data on redeemed prescriptions against skin infections were collected from the National Prescription Register. The intensity of prescription-use by hyperhidrosis status was assessed in Andersen-Gill models.

RESULTS: Overall, 4,176 (9.6%) of 43,477 blood donors had self-reported hyperhidrosis and 437 (0.34%) of 127,823 blood donors had hospital diagnosed hyperhidrosis. Self-reported hyperhidrosis was associated with the use of antibiotic prescriptions (adjusted hazard ratio = 1.21; 95% confidence interval 1.00-1.45, p = 0.047). Hospital diagnosed hyperhidrosis was associated with the use of antibiotic (adjusted hazard ratio = 1.33; 95% confidence interval 1.03-1.68, p = 0.028) and topical antifungal prescriptions (adjusted hazard ratio = 1.43; 95% confidence interval 1.04-1.97, p = 0.027).

CONCLUSIONS: Hyperhidrosis is associated with the use of prescriptions for antibiotics and topical antifungals. This suggests a clinically relevant association between hyperhidrosis and skin infections.

Original language	English
Journal	Journal of Dermatological Treatment
Volume	33
Issue number	4
Pages (from-to)	2263-2269
Number of pages	7
ISSN	0954-6634
DOIs	https://doi.org/10.1080/09546634.2021.1944971
Publication status	Published - Jun 2022

Keywords

Antibiotics
antifungals
cohort study
hyperhidrosis
Humans
Risk Factors
Proportional Hazards Models
Retrospective Studies
Anti-Bacterial Agents/therapeutic use
Hyperhidrosis/drug therapy

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Henning, M. A. S., Ibler, K. S., Ostrowski, S. R., Erikstrup, C., Nielsen, K. R., Bruun, M. T., Hjalgrim, H., Ullum, H., Didriksen, M., Dinh, K. M., Rostgaard, K., Pedersen, O. B., & Jemec, G. B. (2022). Hyperhidrosis and the risk of being treated for skin infections. Journal of Dermatological Treatment, 33(4), 2263-2269. Advance online publication. https://doi.org/10.1080/09546634.2021.1944971

@article{564f18def4224a8694f4c258702f8379,

title = "Hyperhidrosis and the risk of being treated for skin infections",

abstract = "BACKGROUND: A few studies have described an increased prevalence of skin infections in individuals with hyperhidrosis compared to others. However, it remains uncertain whether hyperhidrosis is an independent risk factor for skin infections.OBJECTIVE: To compare the risk of skin infections in individuals with and without hyperhidrosis.METHODS: In this retrospective cohort study, data on hyperhidrosis were collected from the Danish Blood Donor Study. Blood donors included in 2010-2019 were followed from inclusion until December 2019. Data on redeemed prescriptions against skin infections were collected from the National Prescription Register. The intensity of prescription-use by hyperhidrosis status was assessed in Andersen-Gill models.RESULTS: Overall, 4,176 (9.6%) of 43,477 blood donors had self-reported hyperhidrosis and 437 (0.34%) of 127,823 blood donors had hospital diagnosed hyperhidrosis. Self-reported hyperhidrosis was associated with the use of antibiotic prescriptions (adjusted hazard ratio = 1.21; 95% confidence interval 1.00-1.45, p = 0.047). Hospital diagnosed hyperhidrosis was associated with the use of antibiotic (adjusted hazard ratio = 1.33; 95% confidence interval 1.03-1.68, p = 0.028) and topical antifungal prescriptions (adjusted hazard ratio = 1.43; 95% confidence interval 1.04-1.97, p = 0.027).CONCLUSIONS: Hyperhidrosis is associated with the use of prescriptions for antibiotics and topical antifungals. This suggests a clinically relevant association between hyperhidrosis and skin infections.",

keywords = "Antibiotics, antifungals, cohort study, hyperhidrosis, Humans, Risk Factors, Proportional Hazards Models, Retrospective Studies, Anti-Bacterial Agents/therapeutic use, Hyperhidrosis/drug therapy",

author = "Henning, {Mattias A. S.} and Ibler, {Kristina S.} and Ostrowski, {Sisse R.} and Christian Erikstrup and Nielsen, {Kaspar R.} and Bruun, {Mie T.} and Henrik Hjalgrim and Henrik Ullum and Maria Didriksen and Dinh, {Khoa M.} and Klaus Rostgaard and Pedersen, {Ole B.} and Jemec, {Gregor B.}",

year = "2022",

month = jun,

doi = "10.1080/09546634.2021.1944971",

language = "English",

volume = "33",

pages = "2263--2269",

journal = "Journal of Dermatological Treatment",

issn = "0954-6634",

publisher = "Taylor & Francis",

number = "4",

}

TY - JOUR

T1 - Hyperhidrosis and the risk of being treated for skin infections

AU - Henning, Mattias A. S.

AU - Ibler, Kristina S.

AU - Ostrowski, Sisse R.

AU - Erikstrup, Christian

AU - Nielsen, Kaspar R.

AU - Bruun, Mie T.

AU - Hjalgrim, Henrik

AU - Ullum, Henrik

AU - Didriksen, Maria

AU - Dinh, Khoa M.

AU - Rostgaard, Klaus

AU - Pedersen, Ole B.

AU - Jemec, Gregor B.

PY - 2022/6

Y1 - 2022/6

N2 - BACKGROUND: A few studies have described an increased prevalence of skin infections in individuals with hyperhidrosis compared to others. However, it remains uncertain whether hyperhidrosis is an independent risk factor for skin infections.OBJECTIVE: To compare the risk of skin infections in individuals with and without hyperhidrosis.METHODS: In this retrospective cohort study, data on hyperhidrosis were collected from the Danish Blood Donor Study. Blood donors included in 2010-2019 were followed from inclusion until December 2019. Data on redeemed prescriptions against skin infections were collected from the National Prescription Register. The intensity of prescription-use by hyperhidrosis status was assessed in Andersen-Gill models.RESULTS: Overall, 4,176 (9.6%) of 43,477 blood donors had self-reported hyperhidrosis and 437 (0.34%) of 127,823 blood donors had hospital diagnosed hyperhidrosis. Self-reported hyperhidrosis was associated with the use of antibiotic prescriptions (adjusted hazard ratio = 1.21; 95% confidence interval 1.00-1.45, p = 0.047). Hospital diagnosed hyperhidrosis was associated with the use of antibiotic (adjusted hazard ratio = 1.33; 95% confidence interval 1.03-1.68, p = 0.028) and topical antifungal prescriptions (adjusted hazard ratio = 1.43; 95% confidence interval 1.04-1.97, p = 0.027).CONCLUSIONS: Hyperhidrosis is associated with the use of prescriptions for antibiotics and topical antifungals. This suggests a clinically relevant association between hyperhidrosis and skin infections.

AB - BACKGROUND: A few studies have described an increased prevalence of skin infections in individuals with hyperhidrosis compared to others. However, it remains uncertain whether hyperhidrosis is an independent risk factor for skin infections.OBJECTIVE: To compare the risk of skin infections in individuals with and without hyperhidrosis.METHODS: In this retrospective cohort study, data on hyperhidrosis were collected from the Danish Blood Donor Study. Blood donors included in 2010-2019 were followed from inclusion until December 2019. Data on redeemed prescriptions against skin infections were collected from the National Prescription Register. The intensity of prescription-use by hyperhidrosis status was assessed in Andersen-Gill models.RESULTS: Overall, 4,176 (9.6%) of 43,477 blood donors had self-reported hyperhidrosis and 437 (0.34%) of 127,823 blood donors had hospital diagnosed hyperhidrosis. Self-reported hyperhidrosis was associated with the use of antibiotic prescriptions (adjusted hazard ratio = 1.21; 95% confidence interval 1.00-1.45, p = 0.047). Hospital diagnosed hyperhidrosis was associated with the use of antibiotic (adjusted hazard ratio = 1.33; 95% confidence interval 1.03-1.68, p = 0.028) and topical antifungal prescriptions (adjusted hazard ratio = 1.43; 95% confidence interval 1.04-1.97, p = 0.027).CONCLUSIONS: Hyperhidrosis is associated with the use of prescriptions for antibiotics and topical antifungals. This suggests a clinically relevant association between hyperhidrosis and skin infections.

KW - Antibiotics

KW - antifungals

KW - cohort study

KW - hyperhidrosis

KW - Humans

KW - Risk Factors

KW - Proportional Hazards Models

KW - Retrospective Studies

KW - Anti-Bacterial Agents/therapeutic use

KW - Hyperhidrosis/drug therapy

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U2 - 10.1080/09546634.2021.1944971

DO - 10.1080/09546634.2021.1944971

M3 - Journal article

C2 - 34152896

SN - 0954-6634

VL - 33

SP - 2263

EP - 2269

JO - Journal of Dermatological Treatment

JF - Journal of Dermatological Treatment

IS - 4

ER -

Hyperhidrosis and the risk of being treated for skin infections

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Keywords

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