Identifying responders to trastuzumab therapy in breast cancer

Anja Brügmann, Boe Sandahl Sørensen

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

In breast cancer, HER2-targeted therapy with trastuzumab has gained significant attention, owing to the dramatic response observed in a subset of HER2-positive patients. The mechanisms of action are complex and not fully understood, and much effort has been spent in order to identify responders. Good patient management, side effects of the humanized monoclonal antibody and socioeconomics all demand that the drug should be administered only to the patients who will benefit from it. This has been a difficult task and contributions to solve it have been proposed from a variety of research. In this article we describe some of these contributions based on the literature and provide our viewpoint as to which identifiers will emerge in the following decade.
Original languageEnglish
JournalFuture Oncology
Volume7
Pages (from-to)767-73
Number of pages7
ISSN1479-6694
DOIs
Publication statusPublished - 1 Jun 2011
Externally publishedYes

Keywords

  • Animals
  • Antibodies, Monoclonal
  • Antineoplastic Agents
  • Breast Neoplasms
  • Drug Resistance, Neoplasm
  • Female
  • Humans
  • Receptor, erbB-2

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