Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry

Marco Proietti*, Marco Vitolo, Stephanie L Harrison, Deirdre Lane, Laurent Fauchier, Francisco Marin, Michael Nabauer, Tatjana S Potpara, Gheorghe-Andrei Dan, Giuseppe Boriani, Gregory Yoke Hong Lip, ESC-EHRA EORP-AF Long-Term General Registry Investigators, Sam Riahi (Member of study group), Albert Marni Joensen (Member of study group)

*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)
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Abstract

Background: Epidemiological studies in atrial fibrillation (AF) illustrate that clinical complexity increase the risk of major adverse outcomes. We aimed to describe European AF patients’ clinical phenotypes and analyse the differential clinical course. Methods: We performed a hierarchical cluster analysis based on Ward’s Method and Squared Euclidean Distance using 22 clinical binary variables, identifying the optimal number of clusters. We investigated differences in clinical management, use of healthcare resources and outcomes in a cohort of European AF patients from a Europe-wide observational registry. Results: A total of 9363 were available for this analysis. We identified three clusters: Cluster 1 (n = 3634; 38.8%) characterized by older patients and prevalent non-cardiac comorbidities; Cluster 2 (n = 2774; 29.6%) characterized by younger patients with low prevalence of comorbidities; Cluster 3 (n = 2955;31.6%) characterized by patients’ prevalent cardiovascular risk factors/comorbidities. Over a mean follow-up of 22.5 months, Cluster 3 had the highest rate of cardiovascular events, all-cause death, and the composite outcome (combining the previous two) compared to Cluster 1 and Cluster 2 (all P <.001). An adjusted Cox regression showed that compared to Cluster 2, Cluster 3 (hazard ratio (HR) 2.87, 95% confidence interval (CI) 2.27–3.62; HR 3.42, 95%CI 2.72–4.31; HR 2.79, 95%CI 2.32–3.35), and Cluster 1 (HR 1.88, 95%CI 1.48–2.38; HR 2.50, 95%CI 1.98–3.15; HR 2.09, 95%CI 1.74–2.51) reported a higher risk for the three outcomes respectively. Conclusions: In European AF patients, three main clusters were identified, differentiated by differential presence of comorbidities. Both non-cardiac and cardiac comorbidities clusters were found to be associated with an increased risk of major adverse outcomes.

Original languageEnglish
Article number256
JournalB M C Medicine
Volume19
Issue number1
Number of pages17
ISSN1741-7015
DOIs
Publication statusPublished - 20 Oct 2021

Bibliographical note

© 2021. The Author(s).

Keywords

  • Atrial fibrillation
  • Clinical management
  • Clinical phenotypes
  • Cluster analysis
  • Major adverse outcomes

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      Novikova, T. (Contributor), Daniela, R. (Contributor), Maupain, C. (Contributor), Bobescu, E. (Contributor), Mairesse, G. (Contributor), Young, E. (Contributor), Vettus, R. (Contributor), Neiner, S. (Contributor), Badila, E. (Contributor), Kunev, B. (Contributor), Krysiak, W. (Contributor), Granier, M. (Contributor), Canpolat, U. (Contributor), Toma, N. (Contributor), Stockport, J. (Contributor), Ziemi?ska-?u?, M. (Contributor), Balachandran, K. (Contributor), Wilhelm, K. (Contributor), Zajac, P. (Contributor), Borowiec, A. (Contributor), van Eck, E. M. (Contributor), Slowikowski, A. (Contributor), Xuereb, R. (Contributor), Rice, P. (Contributor), Goerg, C. (Contributor), Jedrzejczyk-Patej, E. (Contributor), Robinson, M. (Contributor), Ko?odziej, M. (Contributor), Uiterwaal, H. (Contributor), Egdell, R. (Contributor), Brunn, J. (Contributor), Bertomeu Gonzalez, G. V. (Contributor), Brockway, L. (Contributor), Tjeerdsma, G. (Contributor), Wcislo, T. (Contributor), Alina-Ramona, N. (Contributor), Wadams, B. (Contributor), Greenwood, E. (Contributor), Buckley, C. (Contributor), Beitar, T. (Contributor), B?aszczyk, H. (Contributor), Davies, K. (Contributor), Gotonelia, N. (Contributor), Tendera, M. (Contributor), Sus, I. (Contributor), Lip, G. Y. H. (Creator), Jegere, S. (Contributor), Beerachee, Y. (Contributor), Biedron, M. (Contributor), Morgado, F. (Contributor), Tokmakova, M. (Contributor), Pruchniewicz, E. (Contributor), Hunt, J. (Contributor), Tudgay, S. (Contributor), Lloyd-Jones, H. (Contributor), Potpara, T. S. (Creator), Garc?a Fernandez, F. A. (Contributor), H?tz, H. (Contributor), Kowalik-Sztylc, A. (Contributor), Lurina, B. (Contributor), Neefs, J. (Contributor), Milosevic, N. (Contributor), Brown, J. (Contributor), Ilic, S. (Contributor), Leperchois-Jacquey, C. (Contributor), Arnault, I. (Contributor), Mitic, V. (Contributor), Anguita, M. (Contributor), Simiera, M. (Contributor), Kelsall, N. (Contributor), Stancheva, N. (Contributor), Dupuis, J. (Contributor), Kratz, E. (Contributor), Landgraf, S. (Contributor), Orenes Pi?ero, P. E. (Contributor), Allison, J. (Contributor), Davy, J. (Contributor), Boskovic, A. (Contributor), Stenzel, G. (Contributor), Jan, A. (Contributor), Blommaert, D. (Contributor), Beech, S. (Contributor), Foth, K. (Contributor), Nabauer, M. (Creator), Yncheva, T. (Contributor), Whiteside, C. (Contributor), Fragtrup Hellum, H. C. (Contributor), Laschinger, T. (Contributor), Harrison, S. L. (Creator), Verheij, H. (Contributor), Turcin Halka, H. V. (Contributor), Cimaglia, P. (Contributor), Kaba, R. (Contributor), Hoffer, E. (Contributor), Waintraub, X. (Contributor), Leparr?e, S. (Contributor), Andersen, M. (Contributor), Logemann, A. (Contributor), Fidyk, A. (Contributor), Fauchier, L. (Creator), Ploesteanu, R. (Contributor), Odinsova, S. (Contributor), Leroy, J. (Contributor), Gagirci, G. (Contributor), Reid, L. (Contributor), Ingram, T. (Contributor), Majos, E. (Contributor), Shah, D. (Contributor), Soiron, G. (Contributor), Taggu, W. (Contributor), Marmelo, B. (Contributor), Austin, R. (Contributor), Seddon, M. (Contributor), Ozcan, T. (Contributor), Solodovnicova, E. (Contributor), Loachim Popescu, P. M. (Contributor), Lengerer, S. (Contributor), Pencic, B. (Contributor), Moreira, D. (Contributor), Dickinson, C. (Contributor), Leal, M. (Contributor), Miller, C. (Contributor), Sokal, A. (Contributor), Schaeffer, B. (Contributor), Greenwell, D. (Contributor), McDonald, J. (Contributor), Andersen, K. (Contributor), Burg, M. R. (Contributor), Demir, M. (Contributor), Mingam, R. (Contributor), Fontes, P. (Contributor), Costa, F. (Contributor), Fantecchi, E. (Contributor), Romero Aniorte, A. A. (Contributor), Goffin, K. (Contributor), Dan, R. (Creator), Lipski, P. (Contributor), Stefan, L. (Contributor), Lacoste, J. (Contributor), Bartholome, S. (Contributor), Vonderhagen, E. (Contributor), Qoriani, G. (Contributor), Hegya, D. (Contributor), Cheggour, S. (Contributor), Kaya, H. (Contributor), Runnett, C. (Contributor), Mills, H. (Contributor), Toprak, N. (Contributor), Stojanovic, S. (Contributor), Tintea, E. (Contributor), Petrykowska, K. (Contributor), Vijgen, J. (Contributor), Benham, L. (Contributor), Miranda, R. (Contributor), Hostiuc, M. (Contributor), Biffi, M. (Contributor), Zaman, J. (Contributor), Bouckaert, N. (Contributor), Arend, C. (Contributor), Bakalska-Georgieva, S. (Contributor), Beer, A. (Contributor), Tisheva, S. (Contributor), Olejnik, A. (Contributor), Leopold-Jadczyk, A. (Contributor), Le Bidan, B. M. (Contributor), Pescariu, S. (Contributor), Stoickov, V. (Contributor), Gil Ortega, O. M. (Contributor), Rimbas, R. (Contributor), Peters, C. (Contributor), Andrews, N. (Contributor), Graversen, B. (Contributor), van Doorn, D. W. (Contributor), Kassim, H. (Contributor), Dan, A. (Creator), Piat, C. (Contributor), Felmeden, L. (Contributor), Van Es, E. J. (Contributor), Dan, G. (Creator), Kalarus, Z. (Contributor), Petrovic, M. (Contributor), Zavyalova, O. (Contributor), Fletcher, L. (Contributor), Wood, A. (Contributor), Tamara, T. (Contributor), Diker, E. (Contributor), Sch?n, B. (Contributor), Range, G. (Contributor), Koziel, M. (Contributor), Gherghinescu, C. (Contributor), Casta?o, S. (Contributor), Paparisto, V. (Contributor), Leonard, D. (Contributor), Sekularac, N. (Contributor), Tonks, L. (Contributor), Kriete, M. (Contributor), Pavlovic-Kleut, M. (Contributor), Boos, C. (Contributor), Corina, A. (Contributor), Andric, A. (Contributor), Jordanova, S. (Contributor), Lozance, N. (Contributor), Schaeffer, G. (Contributor), Shalganov, T. (Contributor), Ionac, A. (Contributor), Boros, F. (Contributor), Maziarski, P. (Contributor), Blicharz, J. (Contributor), Szwed, H. (Contributor), Zoccali, C. (Contributor), Yuksel, S. (Contributor), Sorensen, B. (Contributor), Mussagaliyeva, A. (Contributor), Georgiana, C. (Contributor), Natelashvili, N. (Contributor), Dietz, D. (Contributor), Janion, M. (Contributor), Rodionova, L. (Contributor), Ciudad, M. (Contributor), Proskynitopoulos, N. (Contributor), Vassali?re, C. (Contributor), Dyduch-Fejklowicz, B. (Contributor), L?ndle, V. (Contributor), Winum, P. (Contributor), Da Costa, C. A. (Contributor), Erglis, A. (Contributor), Rahel, B. (Contributor), Philippens, S. (Contributor), Jakubowski, P. (Contributor), Saul, V. (Contributor), Gerardy, A. (Contributor), Bairamukova, A. (Contributor), Zakrzewski, M. (Contributor), Gonzalez Juanatey, J. J. (Contributor), Eckardt, L. (Contributor), Badenco, N. (Contributor), Brennan, O. (Contributor), Anneken, L. (Contributor), Shantsila, A. (Contributor), Mutscher, I. (Contributor), Uzunselvi, A. (Contributor), Hoskamp, J. (Contributor), Delgado, A. (Contributor), Simmons, D. (Contributor), Taleski, J. (Contributor), Madgwick, P. (Contributor), Evrard, P. (Contributor), Zlatanovik, N. (Contributor), Svejgaard, M. (Contributor), Bal, Z. (Contributor), Potpara, T. (Creator), Mouquet, V. (Contributor), Streb, W. (Contributor), Sander, C. (Contributor), Mazurek, M. (Contributor), Drozdova, E. (Contributor), Meeder, J. (Contributor), Shah, D. (Contributor), Keenan, S. (Contributor), Hassler, N. (Contributor), Przybylska, A. (Contributor), Aring, J. (Contributor), Himbert, C. (Contributor), Proietti, M. (Creator), Magalh?es, P. (Contributor), Piot, O. (Contributor), Dimkovic, S. (Contributor), Kulzida, K. (Contributor), Uecker, C. (Contributor), Otero-Ravi?a, F. (Contributor), Wiggers, P. (Contributor), Moser, J. (Contributor), Luchkina, I. (Contributor), Winter, K. (Contributor), Ko?, M. (Contributor), Gl?ggler, S. (Contributor), O?Donohoe, L. (Contributor), Atmaca, Y. (Contributor), Le?o, S. (Contributor), Utech, A. (Contributor), Acimovic, T. (Contributor), Celic, V. (Contributor), Vukmirovic, M. (Contributor), Kazakevich, E. (Contributor), el Husseini, H. Z. (Contributor), Lynggaard, V. (Contributor), Riahi, S. (Contributor), Kasprzak, J. (Contributor), Wrigley, B. (Contributor), Howard, L. (Contributor), Z?ra, E. (Contributor), Milgate, S. (Contributor), Cretu, D. (Contributor), McKenzie, D. (Contributor), Yuksel, Y. (Contributor), Brady, R. (Contributor), Sutton, J. (Contributor), Rennie, K. (Contributor), Esakia, A. (Contributor), Marin, F. (Creator), Singh, R. (Contributor), Ekmek?iu, U. (Contributor), Yotov, Y. (Contributor), Ulrych, R. (Contributor), Van Eeckhoutte, E. H. (Contributor), Damiano, P. (Contributor), Friart, A. (Contributor), Garg, S. (Contributor), Martins Oliveira, O. M. (Contributor), Nikolov, F. (Contributor), Martens, E. (Contributor), van den Berg, D. B. N. (Contributor), Holst Hansen, H. C. (Contributor), Szyma?ska, M. (Contributor), Schoeler, J. (Contributor), Erglis, A. (Contributor), Thomas, H. (Contributor), Hvilsted Rasmussen, R. L. (Contributor), Poulard, J. (Contributor), Atar, D. (Contributor), Koopman, P. (Contributor), Gibson, E. (Contributor), Petrescu, L. (Contributor), Arnold, M. (Contributor), Mangea, M. (Contributor), Poultney, U. (Contributor), Morby, L. (Contributor), Brendel, M. (Contributor), Sinha, M. (Contributor), Van Dorpe, D. A. (Contributor), Buzea, A. (Contributor), Degenhardt, R. (Contributor), Rodrigues, B. (Contributor), Muir, J. (Contributor), Kub??kov?, M. (Contributor), Popescu, I. (Contributor), Riabaia, I. (Contributor), Kepez, A. (Contributor), Kovacevic, S. (Contributor), Hunt, A. (Contributor), Featherstone, J. (Contributor), Nastevska, S. (Contributor), Berger, M. (Contributor), Le Moal, M. V. (Contributor), Petkar, S. (Contributor), Kalejs, O. (Contributor), Walker, E. (Contributor), Demirtas, B. (Contributor), Duquenne, H. (Contributor), Ciurus, T. (Contributor), Nowalany-Kozielska, E. (Contributor), Jones, R. (Contributor), Mansourati, J. (Contributor), Payne, O. (Contributor), Vasic, V. (Contributor), Martignani, C. (Contributor), Harc-Dyl, E. (Contributor), Ryan, S. (Contributor), Ferreira da Silva, D. S. G. (Contributor), Lenarczyk, R. (Contributor), Dinu-Andrei, D. (Contributor), Frost, L. (Contributor), Schellner, M. (Contributor), Laure, C. (Contributor), Zlatar, M. (Contributor), Thorpe, K. (Contributor), Klaus, C. (Contributor), Gerlach, A. (Contributor), Felmeden, D. (Contributor), Martel, I. (Contributor), Adams, L. (Contributor), Goda, A. (Contributor), Oster, D. (Contributor), Fechner, S. (Contributor), Rus, H. (Contributor), Santos, J. (Contributor), Ferrari, R. (Contributor), Taborsky, M. (Contributor), Frunza, S. (Contributor), Djouadi, K. (Contributor), Brophy, K. (Contributor), Lef?vre, M. (Contributor), Crijns, H. (Contributor), Toncev, D. (Contributor), Galvao Santos, S. P. (Contributor), Galasko, G. (Contributor), Pierard, L. (Contributor), Taschareck, A. (Contributor), Drozdz, J. (Contributor), Zieli?ski, L. (Contributor), Winkler, J. (Contributor), Buchanan, L. (Contributor), Zycinski, P. (Contributor), Lazarovska, K. (Contributor), Winiarska-Filipek, A. (Contributor), Hagens, V. (Contributor), Cusack, E. (Contributor), Arhipova, T. (Contributor), Stidolph, B. (Contributor), Simonovic, D. (Contributor), Mintale, I. (Contributor), Goddard, W. (Contributor), Naumann, R. (Contributor), Wrigley, M. (Contributor), Maestre, A. (Contributor), McMahon, S. (Contributor), Veliz Mart?nez, M. A. (Contributor), Napp, A. (Contributor), Beveridge, M. (Contributor), Milanov, M. (Contributor), Czapla, W. (Contributor), Opolski, G. (Contributor), Jeewooth, A. (Contributor), Lellouche, N. (Contributor), Skura, M. (Contributor), Axthelm, C. (Contributor), Szafarz, P. (Contributor), Karasi?ski, J. (Contributor), Darabantiu, D. (Contributor), Investigators, O. B. O. T. E. E. L. G. R. (Contributor), William, F. (Contributor), Grant, S. (Contributor), Zdravkovic, M. (Contributor), Celentano, C. (Contributor), Ciobanu, A. (Contributor), Donaldson, D. (Contributor), Cachia, M. (Contributor), Mehltretter, G. (Contributor), Santini, M. (Contributor), Chastre, T. (Contributor), Rewbury, J. (Contributor), Svenningsen, A. (Contributor), Frommhold, A. (Contributor), Adams, C. (Contributor), Vuleta, M. (Contributor), Alin, D. (Contributor), Haynes, R. (Contributor), Vinereanu, D. (Contributor), Simovic, S. (Contributor), May, O. (Contributor), Dejanovic, B. (Contributor), Shutova, J. (Contributor), Hill, J. (Contributor), Tavazzi, L. (Contributor), Costa, A. (Contributor), Fauchier, L. (Creator), Boscher, D. (Contributor), Riahi, S. (Contributor), Westermeier, D. (Contributor), Taggeselle, J. (Contributor), Erk?ner, O. (Contributor), Ahadi, N. (Contributor), Gumberidze, N. (Contributor), Hoffmann, B. (Contributor), Loughlin, A. (Contributor), Xhaet, O. (Contributor), Tymi?ska, A. (Contributor), Pick, S. (Contributor), Boussy, T. (Contributor), Owen, C. (Contributor), Messer, S. (Contributor), Szpot, M. (Contributor), Haag, A. (Contributor), Hough, M. (Contributor), Oudihat, M. (Contributor), Belcher, G. (Contributor), De Groot, G. J. (Contributor), Bahadur, S. (Contributor), Balian, L. (Contributor), Loehndorf, S. (Contributor), Udroiu, C. (Contributor), Kubicius, A. (Contributor), Markovic, S. (Contributor), Antovski, A. (Contributor), Ciutea, M. (Contributor), Stancombe, L. (Contributor), Dolu, A. K. (Contributor), Raepers, M. (Contributor), Mirrakhimov, E. (Contributor), Fedida, J. (Contributor), Milanov, S. (Contributor), Bolger, A. (Contributor), Malavasi, V. L. (Contributor), Binnema, R. (Contributor), Panagopoulos, V. (Contributor), Sucu, M. (Contributor), Gibbs, C. (Contributor), Michalczyk, L. (Contributor), Muskens, A. (Contributor), Romeyer-Bouchard, C. (Contributor), Lopez, C. (Contributor), Hettwer, S. (Contributor), Tivenan, H. (Contributor), Karthikeyan, V. (Contributor), Feusette, P. (Contributor), Krogh Ven?, V. S. (Contributor), Breukers, W. (Contributor), Saunders, G. (Contributor), Traykov, V. (Contributor), Skinner, A. (Contributor), De Coninck, C. M. (Contributor), Tello Montoliu, M. A. (Contributor), Turner, C. (Contributor), Tica, O. (Contributor), Brunello, I. (Contributor), Gerth, A. (Contributor), Diker, E. (Contributor), Skrobowski, A. (Contributor), Vujisic-Tesic, B. (Contributor), Balsam, P. (Contributor), Polat, N. (Contributor), Crowther, H. (Contributor), Nistor, D. (Contributor), Kerimkulova, A. (Contributor), Gentil-Baron, P. (Contributor), Akin Serdar, S. O. (Contributor), Relph, C. (Contributor), Doka, B. (Contributor), Zhigalov, S. (Contributor), Van Opstal, O. J. (Contributor), Jourdan, A. (Contributor), Zubova, T. (Contributor), Schmidt, T. (Contributor), Shamalla, A. (Contributor), Maria, B. (Contributor), Onrat, E. (Contributor), Mills, C. (Contributor), Orzechowska, A. (Contributor), Stumm, R. (Contributor), Chua, Y. (Contributor), Jones, K. (Contributor), Elbaz, N. (Contributor), Law, J. (Contributor), Lip, G. Y. H. (Creator), Mischke, K. (Contributor), Kuhlmann, M. (Contributor), Isakova, N. (Contributor), Nijmeijer, R. (Contributor), Leclercq, C. (Contributor), Wilson, A. (Contributor), Poposka, L. (Contributor), Furber, A. (Contributor), Block, M. (Contributor), Fauchier, L. (Creator), Piot, O. (Contributor), Deceuninck, O. (Contributor), Sobolewska, J. (Contributor), Wilson, T. (Contributor), Mirrakhimov, E. (Contributor), Monogarova, Y. (Contributor), Zink, M. (Contributor), McKie, H. (Contributor), Marchov, D. (Contributor), Petrovic, N. (Contributor), Catanescu, G. (Contributor), Rautureau, J. (Contributor), Fortomaroska Milevska, M. B. (Contributor), Haeussler-Schuchardt, M. (Contributor), Abalea, J. (Contributor), Bell, L. (Contributor), Suttling, A. (Contributor), Baluta, M. (Contributor), Santos, L. (Contributor), Ritter, O. (Contributor), Kuridze, N. (Contributor), Gammelmark, A. (Contributor), Dayal, N. (Contributor), Muda, P. (Contributor), Schmid, A. (Contributor), Milligan, W. (Contributor), Hordy?ski, G. (Contributor), Peric, V. (Contributor), Willems, S. (Contributor), Wenzel, I. (Contributor), Pasieka, M. (Contributor), Cinteza, M. (Contributor), Herzet, J. (Contributor), Delarche, N. (Contributor), Lip, G. Y. H. (Creator), Stephenson, L. (Contributor), Bartos, D. (Contributor), Sahin, D. (Contributor), Dan, G. (Creator), Staszel, M. (Contributor), Ha?as, K. (Contributor), Prasa?, M. (Contributor), Ari, H. (Contributor), Sipic, M. (Contributor), Yilmaz, K. (Contributor), Jovevska, S. (Contributor), McKinley, S. (Contributor), Quintana Giner, G. M. (Contributor), Koshum-Bayeva, K. (Contributor), Massoz, M. (Contributor), Uskov, V. (Contributor), Smallwood, A. (Contributor), Koestler, A. (Contributor), Steiner, S. (Contributor), Holbrook, B. (Contributor), Potpara, T. (Creator), Baumer, A. (Contributor), Arnaud, D. (Contributor), Lazarova, E. (Contributor), Mr?z, I. (Contributor), Gjergo, H. (Contributor), Gorka, H. (Contributor), Gabor, A. (Contributor), Lacrimini, M. (Contributor), Fuller, J. (Contributor), Brown, C. (Contributor), Atar, D. (Contributor), Rheinert, C. (Contributor), Le Heuzey, H. J. (Contributor), Said, S. (Contributor), Popescu, R. (Contributor), Pawlowski, T. (Contributor), Schnabel, A. (Contributor), Hinic, S. (Contributor), Yakova, D. (Contributor), Kaminskiene, S. (Contributor), Stasiak, M. (Contributor), Brand?o Alves, A. L. (Contributor), Patrascu, N. (Contributor), Pedley, L. (Contributor), Boni, S. (Contributor), Bajraktarova Proseva, P. T. (Contributor), Kuppens, C. (Contributor), Morka, J. (Contributor), Peres, M. (Contributor), Vester, S. (Contributor), Gencheva, D. (Contributor), Howe, S. (Contributor), Denart, M. (Contributor), Bicescu, G. (Contributor), Umaar, S. (Contributor), Lachor-Broda, M. (Contributor), Pitt-Kerby, T. (Contributor), Livia, M. (Contributor), K?ster, S. (Contributor), Fumagalli, S. (Contributor), Cottam, V. (Contributor), Reith, R. (Contributor), Pippard, L. (Contributor), Menabde, I. (Contributor), Abela, E. (Contributor), Warwicker, S. (Contributor), Jhagra, O. (Contributor), Almeida, S. (Contributor), Watts, J. (Contributor), Adams, M. (Contributor), Khan, M. (Contributor), Aarup, A. (Contributor), Kisheva, A. (Contributor), Patel, T. (Contributor), Board, S. (Contributor), Najafian, J. (Contributor), Ashton, A. (Contributor), Neuhoff, I. (Contributor), Winstanley, L. (Contributor), Vitolo, M. (Creator), Wancerz, A. (Contributor), Maggioni, A. P. (Contributor), Cozma, A. (Contributor), Jefferey, P. (Contributor), Bader, H. (Contributor), Kaye, S. (Contributor), McSkeane, A. (Contributor), Antoniades, L. (Contributor), Stoicescu, C. (Contributor), Salihova, Z. (Contributor), Widjaja, W. (Contributor), Petrovic, D. (Contributor), Gelev, V. (Contributor), Collins, S. (Contributor), Ziacchi, M. (Contributor), Ille, M. (Contributor), Rahman, I. (Contributor), Luxton, F. (Contributor), Wegink, D. (Contributor), Subkovas, E. (Contributor), Kidd, S. (Contributor), Schneider, M. (Contributor), Maisuradze, D. (Contributor), Roberts, K. (Contributor), Larisa, R. (Contributor), Lenarczyk, R. (Contributor), Etsadashvili, K. (Contributor), Sprynger, M. (Contributor), Taieb, J. (Contributor), Lip, G. (Creator), Pupo, S. (Contributor), Duffy, M. (Contributor), Peller, M. (Contributor), Rold?n Rabadan, R. I. (Contributor), Coborosanu, O. (Contributor), Asanin, M. (Contributor), Hughes, D. (Contributor), Stojanovic, M. (Contributor), Mar?n, F. (Contributor), Schneider, P. (Contributor), Taneska, N. (Contributor), Adamczewski, J. (Contributor), Desai, H. (Contributor), Burkhardt, D. (Contributor), Iric-Cupic, V. (Contributor), Gaertner, J. (Contributor), Rodionova, L. (Contributor), St?pie?, M. (Contributor), Boreux, J. (Contributor), Bujak, W. (Contributor), Adrag?o, P. (Contributor), Carmo, P. (Contributor), Summerhayes, A. (Contributor), Korsgaard, A. (Contributor), Garc?a Seara, S. J. (Contributor), Boismal, S. (Contributor), Bowring, A. (Contributor), Gasior, Z. (Contributor), Jacob, P. (Contributor), Luckner, E. (Contributor), Koba, E. (Contributor), Soldatova, I. (Contributor), Boyer, M. (Contributor), Manzano Fern?ndez, F. S. (Contributor), Turbanisch, S. (Contributor), Janse, P. (Contributor), Tewelde, H. (Contributor), Partridge, J. (Contributor), Duthoit, G. (Contributor), Kotlar, I. (Contributor), Iqbal, R. (Contributor), Serdechnaya, E. (Contributor), Savovic, Z. (Contributor), Kayapinar, O. (Contributor), Danstrup-Dinesen, P. (Contributor), Dural, I. E. (Contributor), Bryce, M. (Contributor), Frisoni, J. (Contributor), Sennhenn, S. (Contributor), Boriani, G. (Creator), Loayssa, J. (Contributor), Sahin, M. (Contributor), Marin, F. (Creator), Oekinghaus, R. (Contributor), Lepiece, C. (Contributor), Domingos, P. (Contributor), Wester, A. (Contributor), Hurford, F. (Contributor), Richter, J. (Contributor), D?u?niewski, M. (Contributor), Grundt, J. (Contributor), Palacio, M. (Contributor), Daha, I. (Contributor), Obukhov, D. (Contributor), Thornthwaite, S. (Contributor), Baytok, G. (Contributor), Haissaguerre, M. (Contributor), Grech, A. (Contributor), Gandjbakhch, E. (Contributor), Coles, D. (Contributor), Cordeiro, A. (Contributor), Van Hauwaert, H. B. (Contributor), Bouet, J. (Contributor), Papiashvili, G. (Contributor), Mibach, H. (Contributor), Broadley, A. (Contributor), Pesce, F. (Contributor), Romanek, J. (Contributor), Bakrecheski, N. (Contributor), Wo?niak, P. (Contributor), Polovina, M. (Contributor), Mibach, F. (Contributor), Gabelmann, M. (Contributor), Ballant, E. (Contributor), Evans, L. (Contributor), Dayer, M. (Contributor), Skorek, E. (Contributor), Shtereva, R. (Contributor), Japie, C. (Contributor), Ndlovu, N. (Contributor), Englmann, E. (Contributor), Holland, M. (Contributor), Alam, I. (Contributor), Tercedor Sanchez, S. L. (Contributor), Oziera?ski, K. (Contributor), Hidden-Lucet, F. (Contributor), Arandjelovic, A. (Contributor), Gorczyca-Michta, I. (Contributor), Leal, M. (Contributor), Radford, E. (Contributor), Ilic, V. (Contributor), Senoo, K. (Contributor), Kschiwan, D. (Contributor), Tebbe, U. (Contributor), Norris, L. (Contributor), Mozid, A. (Contributor), Music, L. (Contributor), Schmitz, K. (Contributor), Haushan, P. (Contributor), Methe, H. (Contributor), Mirone, P. (Contributor), Maerkl, M. (Contributor), Vintila, V. (Contributor), Bosch, R. (Contributor), Eberhard, K. (Contributor), Vold, A. (Contributor), Hansen, S. (Contributor), Pavlovic, M. (Contributor), Dan, G. (Creator), Preston, S. (Contributor), Drakalovic, D. (Contributor), Gevers, R. (Contributor), Dumitrache, N. (Contributor), Mercea, S. (Contributor), Nabauer, M. (Creator), Tjuleneva, L. (Contributor), Goanta, E. (Contributor), Haim, M. (Contributor), Desteghe, L. (Contributor), Sadki, N. (Contributor), Nedeljkovic, M. (Contributor), Ahmad, S. (Contributor), Cotterill, D. (Contributor), Menez, T. (Contributor), Deljanin Ilic, I. M. (Contributor), Bijsterveld, N. (Contributor), Van Rennes, R. B. (Contributor), Pearson, J. (Contributor), Kiliszek, M. (Contributor), Burg, M. (Contributor), Alcalde, O. (Contributor), Wilde, A. (Contributor), Wood, D. (Contributor), Giannini, I. (Contributor), Marni Joensen, J. A. (Contributor), Terchet, A. (Contributor), Wozakowska-Kaplon, B. (Contributor), Stevanovic, A. (Contributor), Gvenetadze, R. (Contributor), Asanovic, D. (Contributor), Randall, H. (Contributor), Hristov, M. (Contributor), Ristovski, V. (Contributor), Ahyt, B. (Contributor), Willems, S. (Contributor), Nabauer, M. (Creator), Roubille, F. (Contributor), Piersma, F. (Contributor), Alves, M. (Contributor), Doncovska, S. (Contributor), Tor, R. (Contributor), Brown, J. (Contributor), Kaes, S. (Contributor), Beckendorf, C. (Contributor), Barth, A. (Contributor), Dragoti, J. (Contributor), Kedev, S. (Contributor), Lange, I. (Contributor), Turk, U. O. (Contributor), Bulatovic, N. (Contributor), Dan, G. (Creator), Mages, V. (Contributor), Tsvyatkov, H. (Contributor), James, K. (Contributor), Kliesch, A. (Contributor), Saric, J. (Contributor), Lebherz, C. (Contributor), Gandhi, N. (Contributor), Ozcan Celebi, C. O. (Contributor), Nyvad, O. (Contributor), Roberts, P. (Contributor), Sheshoski, B. (Contributor), Potpara, T. (Creator), Pereira, H. (Contributor), Di Chiara, C. A. (Contributor), Willard, E. (Contributor), Heitmann, K. (Contributor), Taha Alper, A. A. (Contributor), Williams, L. (Contributor), Goda, A. (Contributor), Doneva, A. (Contributor), Lartsuliani, K. (Contributor), George, M. (Contributor), Nevzorova, V. (Contributor), Button, H. (Contributor), Heidbuchel, H. (Contributor), Melon, P. (Contributor), Lusanova, O. (Contributor), Popovic, Z. (Contributor), Van Genechten, G. G. (Contributor), Pavlovic, N. (Contributor), Vanhear, K. (Contributor), Duygun, A. (Contributor), Tokgozoglu, L. (Contributor), Faes, D. (Contributor), Harman, E. (Contributor), Starling, J. (Contributor), Metherell, S. (Contributor), ?liwi?ski, A. (Contributor), Dabrowski, R. (Contributor), Cozma, D. (Contributor), Bernardo, R. (Contributor), Oboroceanu, L. (Contributor), Simantirakis, E. N. (Contributor), Mau, E. (Contributor), Bhagwandien, R. (Contributor), Mishra, B. (Contributor), Korinth, A. (Contributor), Shantsila, A. (Contributor), Sachse, J. (Contributor), Van Lier, L. D. (Contributor), Doucy, A. (Contributor), Yilmaz, M. B. (Contributor), Ayarra, M. (Contributor), Rusanova, G. (Contributor), Lane, D. A. (Creator), Marijon, E. (Contributor), Hawksworth, C. (Contributor), Vacarescu, C. (Contributor), Engset, I. (Contributor), Perez Cabeza, C. A. (Contributor), Jensen, L. (Contributor), Stanik, W. (Contributor), Budnik, M. (Contributor), Garc?a-Bolao, I. (Contributor), Venn, F. (Contributor), Garc?a Bolao, B. I. (Contributor), Cope, C. (Contributor), Kaul, N. (Contributor), Ribeiro, L. (Contributor), Dechering, D. (Contributor), ?zin, B. (Contributor), Stoehr, A. (Contributor), Grecu, M. (Contributor), Romero, H. (Contributor), Walter, S. (Contributor), Ionescu, G. (Contributor), Gruber, M. (Contributor), Getty, A. (Contributor), Kalarus, Z. (Contributor), van der Ven, D. V. N. (Contributor), Nutt, H. (Contributor), Szabowski, S. (Contributor), Ritscher, G. (Contributor), Dodos, F. (Contributor), Nasser, A. (Contributor), Sagirashvili, E. (Contributor), Mornos, C. (Contributor), F?rtsch, H. (Contributor), Bernucci, D. (Contributor), Tuckis, L. (Contributor), Popescu, I. (Contributor), Kupics, K. (Contributor), Reithmeier, A. (Contributor), Durak, M. (Contributor), Giry, L. (Contributor), Miarka, J. (Contributor), Chlebu?, M. (Contributor), Hudson, K. (Contributor), Krzy?anowski, K. (Contributor), Gartner, C. (Contributor), Tan Kurklu, K. S. (Contributor), Ka?mierczak, J. (Contributor), Schwefer, M. (Contributor), Davidovic, G. (Contributor), Tettersell, S. (Contributor), Hohensee, H. (Contributor), Tabone, T. (Contributor), Szili-Torok, T. (Contributor), Dormal, F. (Contributor), Daraban, A. (Contributor), Musialik-Lydka, A. (Contributor), Russell, K. (Contributor), Kutlu, M. (Contributor), Kozlowski, M. (Contributor), Waggett, L. (Contributor), Haberka, M. (Contributor), Hardman, C. (Contributor), Mirza, P. (Contributor), Azhari, A. (Contributor), Slavcheva, S. (Contributor), Petroska, K. (Contributor), Orthen, R. (Contributor), Esen, E. (Contributor), Sharp, A. (Contributor), Font, M. (Contributor), Vintila, M. (Contributor), Jubele, K. (Contributor), Hussain, S. (Contributor), Rieker, W. (Contributor), Fahrig, A. (Contributor), Scheibner, T. (Contributor), Natalia, C. (Contributor), Djikic, D. (Contributor), Pavin, D. (Contributor), Orski, Z. (Contributor), Sewell, T. (Contributor), Beacock, D. (Contributor), Cichocka, M. (Contributor), Boury, F. (Contributor), Fairlamb, H. (Contributor), Crijns, H. (Contributor), Steiner, S. (Contributor), Pop Moldovan, M. A. (Contributor), Ballesteros, G. (Contributor), Carpintero, M. (Contributor), Diemberger, I. (Contributor), Stephan, C. (Contributor), Tomaszewska-Kiecana, M. (Contributor), Krzemien-Wolska, K. (Contributor), Starosta, P. (Contributor), Earles, S. (Contributor), Brown, R. (Contributor), Livingstone, C. (Contributor), Dymond, H. (Contributor), Meixner, S. (Contributor), Starflinger, A. (Contributor), Kemp, S. (Contributor), Sch?n, N. (Contributor), Zuzans, R. (Contributor) & Stoyanov, M. (Contributor), Figshare, 2021

      DOI: 10.6084/m9.figshare.16835027.v1, https://springernature.figshare.com/articles/journal_contribution/Additional_file_1_of_Impact_of_clinical_phenotypes_on_management_and_outcomes_in_European_atrial_fibrillation_patients_a_report_from_the_ESC-EHRA_EURObservational_Research_Programme_in_AF_EORP-AF_General_Long-Term_Registry/16835027/1

      Dataset

    • Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry

      Proietti, M. (Creator), Vitolo, M. (Creator), Harrison, S. L. (Creator), Lane, D. A. (Creator), Fauchier, L. (Creator), Marin, F. (Creator), Nabauer, M. (Creator), Potpara, T. S. (Creator), Dan, G. (Creator), Boriani, G. (Creator) & Lip, G. Y. H. (Creator), Figshare, 2021

      DOI: 10.6084/m9.figshare.c.5669657, https://springernature.figshare.com/collections/Impact_of_clinical_phenotypes_on_management_and_outcomes_in_European_atrial_fibrillation_patients_a_report_from_the_ESC-EHRA_EURObservational_Research_Programme_in_AF_EORP-AF_General_Long-Term_Registry/5669657

      Dataset

    • Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry

      Proietti, M. (Creator), Vitolo, M. (Creator), Harrison, S. L. (Creator), Lane, D. A. (Creator), Fauchier, L. (Creator), Marin, F. (Creator), Nabauer, M. (Creator), Potpara, T. S. (Creator), Dan, G. (Creator), Boriani, G. (Creator) & Lip, G. Y. H. (Creator), Figshare, 2021

      DOI: 10.6084/m9.figshare.c.5669657.v1, https://springernature.figshare.com/collections/Impact_of_clinical_phenotypes_on_management_and_outcomes_in_European_atrial_fibrillation_patients_a_report_from_the_ESC-EHRA_EURObservational_Research_Programme_in_AF_EORP-AF_General_Long-Term_Registry/5669657/1

      Dataset

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