Impact of postoperative intravenous iron therapy on postoperative infections in older patients with severe anaemia after hip fracture surgery

Lene T. Hansen; Johannes Riis; Kristian H. Kragholm; Lis K. Larsen; Christian Cavallius; Marianne M. Mørch; Silas Z. Clemmensen; Maria L. Krogager; Dorte Melgaard

doi:10.1186/s12877-023-03775-8

Impact of postoperative intravenous iron therapy on postoperative infections in older patients with severe anaemia after hip fracture surgery

Lene T. Hansen^*, Johannes Riis, Kristian H. Kragholm, Lis K. Larsen, Christian Cavallius, Marianne M. Mørch, Silas Z. Clemmensen, Maria L. Krogager, Dorte Melgaard^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

BACKGROUND: Anaemia is common following hip fracture in ortho-geriatric patients and is associated with postoperative infections.. This study investigated whether intravenous iron supplements reduced the rate of postoperative infections within 30 days postoperatively in older adults after hip fracture surgery.

METHODS: This observational study included 198 ortho-geriatric patients July 2018-May 2020. In May 2019 a local guideline was implemented and recommended II therapy on the 3 rd postoperative day if haemoglobin concentration was < 6.5 mmol/L after hip fracture surgery.

RESULTS: The patients were divided into four treatment groups: blood transfusion (n = 44), IV iron (n = 69), blood transfusion + IV iron (n = 35) and no treatment (n = 50). The number of patients who had an infection within 30 days was similar in the two time periods (38.8% before vs. 38.9% after systematic I.V. iron supplementation, P = 1.00) and no significant difference according to risk of infection was found between treatment groups.

CONCLUSION: This study documents no effect of intravenous iron supplements on postoperative infections in older adults after hip fracture surgery.

TRIAL REGISTRATION: The study was registered with the Danish Data Protection Authority (2008-58-0028) the 2 th of September 2019.

Original language	English
Article number	95
Journal	BMC Geriatrics
Volume	23
Issue number	1
ISSN	1471-2318
DOIs	https://doi.org/10.1186/s12877-023-03775-8
Publication status	Published - 14 Feb 2023

Bibliographical note

Keywords

Geriatric patients
Intravenous iron
Postoperative anaemia
Postoperative infections
Surgery
Humans
Postoperative Complications/drug therapy
Anemia/drug therapy
Aged
Iron
Hip Fractures/surgery

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10.1186/s12877-023-03775-8Licence: CC BY 4.0

Hansen et al. (2023). Impact of postoperative intravenous iron therapy on postoperative infections in older patients with severe anaemia after hip fracture surgeryFinal published version, 799 KBLicence: CC BY 4.0

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title = "Impact of postoperative intravenous iron therapy on postoperative infections in older patients with severe anaemia after hip fracture surgery",

abstract = "BACKGROUND: Anaemia is common following hip fracture in ortho-geriatric patients and is associated with postoperative infections.. This study investigated whether intravenous iron supplements reduced the rate of postoperative infections within 30 days postoperatively in older adults after hip fracture surgery.METHODS: This observational study included 198 ortho-geriatric patients July 2018-May 2020. In May 2019 a local guideline was implemented and recommended II therapy on the 3 rd postoperative day if haemoglobin concentration was < 6.5 mmol/L after hip fracture surgery. RESULTS: The patients were divided into four treatment groups: blood transfusion (n = 44), IV iron (n = 69), blood transfusion + IV iron (n = 35) and no treatment (n = 50). The number of patients who had an infection within 30 days was similar in the two time periods (38.8% before vs. 38.9% after systematic I.V. iron supplementation, P = 1.00) and no significant difference according to risk of infection was found between treatment groups.CONCLUSION: This study documents no effect of intravenous iron supplements on postoperative infections in older adults after hip fracture surgery.TRIAL REGISTRATION: The study was registered with the Danish Data Protection Authority (2008-58-0028) the 2 th of September 2019. ",

keywords = "Geriatric patients, Intravenous iron, Postoperative anaemia, Postoperative infections, Surgery, Humans, Postoperative Complications/drug therapy, Anemia/drug therapy, Aged, Iron, Hip Fractures/surgery",

author = "Hansen, {Lene T.} and Johannes Riis and Kragholm, {Kristian H.} and Larsen, {Lis K.} and Christian Cavallius and M{\o}rch, {Marianne M.} and Clemmensen, {Silas Z.} and Krogager, {Maria L.} and Dorte Melgaard",

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doi = "10.1186/s12877-023-03775-8",

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T1 - Impact of postoperative intravenous iron therapy on postoperative infections in older patients with severe anaemia after hip fracture surgery

AU - Hansen, Lene T.

AU - Riis, Johannes

AU - Kragholm, Kristian H.

AU - Larsen, Lis K.

AU - Cavallius, Christian

AU - Mørch, Marianne M.

AU - Clemmensen, Silas Z.

AU - Krogager, Maria L.

AU - Melgaard, Dorte

PY - 2023/2/14

Y1 - 2023/2/14

N2 - BACKGROUND: Anaemia is common following hip fracture in ortho-geriatric patients and is associated with postoperative infections.. This study investigated whether intravenous iron supplements reduced the rate of postoperative infections within 30 days postoperatively in older adults after hip fracture surgery.METHODS: This observational study included 198 ortho-geriatric patients July 2018-May 2020. In May 2019 a local guideline was implemented and recommended II therapy on the 3 rd postoperative day if haemoglobin concentration was < 6.5 mmol/L after hip fracture surgery. RESULTS: The patients were divided into four treatment groups: blood transfusion (n = 44), IV iron (n = 69), blood transfusion + IV iron (n = 35) and no treatment (n = 50). The number of patients who had an infection within 30 days was similar in the two time periods (38.8% before vs. 38.9% after systematic I.V. iron supplementation, P = 1.00) and no significant difference according to risk of infection was found between treatment groups.CONCLUSION: This study documents no effect of intravenous iron supplements on postoperative infections in older adults after hip fracture surgery.TRIAL REGISTRATION: The study was registered with the Danish Data Protection Authority (2008-58-0028) the 2 th of September 2019.

AB - BACKGROUND: Anaemia is common following hip fracture in ortho-geriatric patients and is associated with postoperative infections.. This study investigated whether intravenous iron supplements reduced the rate of postoperative infections within 30 days postoperatively in older adults after hip fracture surgery.METHODS: This observational study included 198 ortho-geriatric patients July 2018-May 2020. In May 2019 a local guideline was implemented and recommended II therapy on the 3 rd postoperative day if haemoglobin concentration was < 6.5 mmol/L after hip fracture surgery. RESULTS: The patients were divided into four treatment groups: blood transfusion (n = 44), IV iron (n = 69), blood transfusion + IV iron (n = 35) and no treatment (n = 50). The number of patients who had an infection within 30 days was similar in the two time periods (38.8% before vs. 38.9% after systematic I.V. iron supplementation, P = 1.00) and no significant difference according to risk of infection was found between treatment groups.CONCLUSION: This study documents no effect of intravenous iron supplements on postoperative infections in older adults after hip fracture surgery.TRIAL REGISTRATION: The study was registered with the Danish Data Protection Authority (2008-58-0028) the 2 th of September 2019.

KW - Geriatric patients

KW - Intravenous iron

KW - Postoperative anaemia

KW - Postoperative infections

KW - Surgery

KW - Humans

KW - Postoperative Complications/drug therapy

KW - Anemia/drug therapy

KW - Aged

KW - Iron

KW - Hip Fractures/surgery

U2 - 10.1186/s12877-023-03775-8

DO - 10.1186/s12877-023-03775-8

M3 - Journal article

C2 - 36788483

AN - SCOPUS:85148110040

SN - 1471-2318

VL - 23

JO - BMC Geriatrics

JF - BMC Geriatrics

IS - 1

M1 - 95

ER -

Impact of postoperative intravenous iron therapy on postoperative infections in older patients with severe anaemia after hip fracture surgery

Abstract

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