Improved survival due to better renal outcomes in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) during the years 2000 to 2015 - a Danish nationwide study

Karl Emil Nelveg-Kristensen, Wladimir Szpirt, Nicholas Carlson, Jon Waast Gregersen, Elizabeth Krarup, Per Ivarsen, Christian Torp-Pedersen, Martin Egfjord

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Abstract

INTRODUCTION: AAV (granulomatosis with polyangiitis and microscopic polyangiitis) carry significant risk of morbidity and mortality, notwithstanding adequate treatment. It has recently been suggested that incidence rates are increasing and risk of death declining, however, contemporary large-scale descriptive studies, with appropriate follow-up, have been challenged by the rare occurrence of these diseases. Accordingly, we examined these matters by use of Danish nationwide healthcare registries.METHODS: All patients with incident AAV, regardless of primary organ manifestation and severity were included by use of ICD10 diagnostic codes (positive predictive value of \gt; 90\ and grouped in five-year intervals (P1: 2000-2004, P2: 2005-2009, P3: 2010-1015). Absolute risk ratios (ARR) adjusted for age, sex and advanced disease severity (\gt;10 days of initial hospital stay), as well as cumulative incidences were assessed based on the Aalen-Johansen estimator in R version 3.5.0.
Original languageEnglish
Article numberFO057
JournalNephrology, Dialysis, Transplantation
Volume34
Issue numberSupplement_1
Number of pages1
ISSN0931-0509
DOIs
Publication statusPublished - 1 Jun 2019
Event56th ERA-EDTA Congress - Budapest, Hungary
Duration: 13 Jun 201916 Jun 2019

Conference

Conference56th ERA-EDTA Congress
CountryHungary
CityBudapest
Period13/06/201916/06/2019

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