In vitro susceptibility of Campylobacter pyloridis to cimetidine, sucralfate, bismuth and sixteen antibiotics

J J Andreasen, L P Andersen

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39 Citations (Scopus)

Abstract

The in vitro susceptibility of recent Danish human clinical isolates of Campylobacter pyloridis to cimetidine, sucralfate, bismuth subsalicylate and sixteen antimicrobial agents was determined by an agar-dilution technique. Benzylpenicillin was the most active drug (MIC90 = 0.1 microgram/ml); ampicillin, erythromycin, gentamicin and ciprofloxacin were slightly less active. All strains were resistant to 100 micrograms sulfamethizole, and nalidixic acid also had little activity on weight basis. Of the three anti-peptic ulcer drugs, bismuth subsalicylate was most active (MIC90 25 micrograms/ml), but sucralfate and cimetidine also had antibacterial activity, although only little (MIC90 3200 micrograms/ml).

Original languageEnglish
JournalActa pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology
Volume95
Issue number2
Pages (from-to)147-9
Number of pages3
ISSN0108-0180
Publication statusPublished - Apr 1987
Externally publishedYes

Keywords

  • Anti-Bacterial Agents
  • Bismuth
  • Campylobacter
  • Cimetidine
  • Humans
  • Microbial Sensitivity Tests
  • Organometallic Compounds
  • Salicylates
  • Sucralfate

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