Abstract
The in vitro susceptibility of diarrhoea producing Gram negative enteric bacteria to sulfasalazine, 5-aminosalicylic acid, sulfapyridine and four quinolones was investigated using an agar dilution method. All strains were resistant to 1600 micrograms/ml of sulfasalazine and 5-aminosalicylic acid. MIC range of sulfapyridine for Y. enterocolitica was 3.1-25 micrograms/ml (median:6.2) and for Salmonella 25-100 micrograms/ml (median: 100) Campylobacter jejuni/coli were less susceptible to sulfapyridine with MIC values ranging from 200 to 800 micrograms/ml. Shigella and three of five E. coli strains were resistant to 1600 micrograms/ml of sulfapyridine. Two strains of E. coli were inhibited by 25 micrograms/ml. All strains were fairly susceptible to enoxacin, ciprofloxacin, pefloxacin and ofloxacin. Cirpofloxacin was the most active drug on weight basis.
Original language | English |
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Journal | APMIS - Journal of Pathology, Microbiology and Immunology |
Volume | 96 |
Issue number | 6 |
Pages (from-to) | 568-70 |
Number of pages | 3 |
ISSN | 0903-4641 |
Publication status | Published - Jun 1988 |
Externally published | Yes |
Keywords
- Aminosalicylic Acids
- Anti-Bacterial Agents
- Enterobacteriaceae
- Gram-Negative Bacteria
- Mesalamine
- Sulfanilamides
- Sulfapyridine
- Sulfasalazine