Incidence and Clinical Presentation of Moderate to Severe Graves' Orbitopathy in a Danish Population before and after Iodine Fortification of Salt

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Abstract

Context:Population-based data on the incidence and clinical presentation of moderate to severe Graves' orbitopathy (GO) are scarce, and virtually nothing is known on the effect of an iodization program on the incidence and presentation of GO.Objective:The objective of the study was to characterize incident moderate to severe GO in North Jutland County, Denmark, during the period 1992-2009, before and after the Danish salt iodization program.Design and Patients:The design of the study was a prospective register of patients with incident moderate to severe GO in a population during 8.9 million persons × years of observation.Setting:The study was conducted at a thyroid-eye clinic of university hospital.Main Outcome Measures:Clinical presentation and incidence before and after the year 2000 initiation of the mandatory Danish iodization of salt were measured. The incidence of GO was related to the incidence of Graves' hyperthyroidism (GH) in the same population.Results:The incidence rate of moderate to severe GO was 16.1/million per year (women: 26.7; men: 5.4), with no change associated with iodization of salt. The moderate to severe GO incidence was 4.9% of the incidence of GH. The incidence rate ratio between women and men with GO (4.9) was not different from the ratio in GH. Compared with GH, only a few patients (
Original languageEnglish
JournalJournal of Clinical Endocrinology and Metabolism
Volume97
Issue number7
Pages (from-to)2325-2332
Number of pages8
ISSN0021-972X
DOIs
Publication statusPublished - 2012
Externally publishedYes

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