Research output per year
Research output per year
Rasmus Richelsen, Jesper Smit, Pavithra Laxsen Anru, Henrik Carl Schønheyder, Henrik Nielsen
Research output: Contribution to journal › Journal article › Research › peer-review
Background: Data elucidating trends of community-onset extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae infections remain sparse in low prevalence areas. We conducted a population-based study to determine the incidence, temporal trends and co-resistance of community-onset ESBL infections. Methods: We identified all recorded episodes of E. coli and K. pneumoniae bacteraemia and urinary tract infections in adult patients (>15 years) in the North Denmark Region between 2007–2017. Using population-based registries, we obtained information on demographics and place of acquisition, and investigated the standardized incidence rates and temporal trends of community-onset ESBL infections and the associated patterns of co-resistance. Results: A total of 3741 episodes of community-onset ESBL E. coli or K. pneumoniae infections were observed during the study period, with the annual standardized incidence rate increasing from 7.5 to 105 per 100,000 person-years between 2007–2017. The increase was conveyed primarily by a rise in E. coli urinary tract infections shifting from being mainly healthcare-associated to community-acquired. ESBL-producing isolates increased from 0.5 to 4.0% with considerable co-resistance. Conclusion: The proportion of E. coli and K. pneumoniae isolates producing ESBL have increased considerably in the North Denmark Region. The increasing incidence and frequent co-resistance should raise awareness among physicians responsible for empirical antibiotic treatment.
Original language | English |
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Journal | Infectious Diseases |
Volume | 52 |
Issue number | 8 |
Pages (from-to) | 547-556 |
Number of pages | 10 |
ISSN | 2374-4235 |
DOIs | |
Publication status | Published - 2020 |
Research output: PhD thesis
Nielsen, H. (Creator), Richelsen, R. (Creator), Anru, P. L. (Contributor), Sch?nheyder, H. C. (Creator) & Smit, J. (Creator), Taylor & Francis, 2020
DOI: 10.6084/m9.figshare.12296168.v1, https://doi.org/10.6084%2Fm9.figshare.12296168.v1
Dataset