TY - JOUR
T1 - Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load
AU - Lyngse, Frederik Plesner
AU - Mølbak, Kåre
AU - Skov, Robert Leo
AU - Christiansen, Lasse Engbo
AU - Mortensen, Laust Hvas
AU - Albertsen, Mads
AU - Møller, Camilla Holten
AU - Krause, Tyra Grove
AU - Rasmussen, Morten
AU - Michaelsen, Thomas Yssing
AU - Voldstedlund, Marianne
AU - Fonager, Jannik
AU - Steenhard, Nina
AU - Danish Covid-19 Genome Consortium
AU - Kirkeby, Carsten Thure
A2 - Albertsen, Mads
A2 - Brandt, Jakob
A2 - Knutsson, Simon
A2 - Sørensen, Emil Aarre
A2 - Nymann, Thomas
A2 - Petersen, Celine
A2 - Chiche-Lapierre, Clarisse Eve
A2 - Hansen, Frederik Teilfeldt
A2 - Collados, Emilio Fuster
A2 - Berg, Amalie
A2 - Remmer Bielidt, Susanne
A2 - Mølvang Dall, Sebastian
A2 - Dvarionaite, Erika
A2 - Hove Hansen, Susan
A2 - Jørgensen, Vibeke Rudkjøbing
A2 - Nicolajsen, Trine Buus
A2 - Saei, Wagma
A2 - Østergaard, Stine Karstenskov
A2 - Yssing Michaelsen, Thomas
A2 - Le-Quy, Vang
A2 - Sereika, Mantas
A2 - Kirkegaard, Rasmus Hansen
A2 - Andersen, Kasper Skytte
A2 - Andersen, Martin Hjorth
A2 - Hansen, Karsten Kryger
A2 - Boye, Mads
A2 - Bach, Mads Peter
A2 - Dissing, Peter
A2 - Drastrup-Fjordbak, Anton
A2 - Collin, Michael
A2 - Büttner, Finn
A2 - Andersen, Susanne
A2 - Otte, Lea Sass
A2 - Bøgsted, Martin
A2 - Brøndum, Rasmus Froberg
A2 - Hose, Katja
A2 - Sagi, Tomer
A2 - Pakanec, Miroslav
A2 - Krarup, Henrik Bygum
A2 - Fuglsang-Damgaard, David
A2 - Mølvadgaard, Mette
N1 - © 2021. The Author(s).
PY - 2021/12/13
Y1 - 2021/12/13
N2 - New lineages of SARS-CoV-2 are of potential concern due to higher transmissibility, risk of severe outcomes, and/or escape from neutralizing antibodies. Lineage B.1.1.7 (the Alpha variant) became dominant in early 2021, but the association between transmissibility and risk factors, such as age of primary case and viral load remains poorly understood. Here, we used comprehensive administrative data from Denmark, comprising the full population (January 11 to February 7, 2021), to estimate household transmissibility. This study included 5,241 households with primary cases; 808 were infected with lineage B.1.1.7 and 4,433 with other lineages. Here, we report an attack rate of 38% in households with a primary case infected with B.1.1.7 and 27% in households with other lineages. Primary cases infected with B.1.1.7 had an increased transmissibility of 1.5-1.7 times that of primary cases infected with other lineages. The increased transmissibility of B.1.1.7 was multiplicative across age and viral load.
AB - New lineages of SARS-CoV-2 are of potential concern due to higher transmissibility, risk of severe outcomes, and/or escape from neutralizing antibodies. Lineage B.1.1.7 (the Alpha variant) became dominant in early 2021, but the association between transmissibility and risk factors, such as age of primary case and viral load remains poorly understood. Here, we used comprehensive administrative data from Denmark, comprising the full population (January 11 to February 7, 2021), to estimate household transmissibility. This study included 5,241 households with primary cases; 808 were infected with lineage B.1.1.7 and 4,433 with other lineages. Here, we report an attack rate of 38% in households with a primary case infected with B.1.1.7 and 27% in households with other lineages. Primary cases infected with B.1.1.7 had an increased transmissibility of 1.5-1.7 times that of primary cases infected with other lineages. The increased transmissibility of B.1.1.7 was multiplicative across age and viral load.
UR - http://www.scopus.com/inward/record.url?scp=85122774462&partnerID=8YFLogxK
U2 - 10.1038/s41467-021-27202-x
DO - 10.1038/s41467-021-27202-x
M3 - Journal article
C2 - 34903718
SN - 2041-1723
VL - 12
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 7251
ER -