Increased urinary loss of uric acid in adults with acute respiratory failure requiring mechanical ventilation

E F Christensen, J Jacobsen, E Anker-Møller, P Schultz, N Spangsberg

Research output: Contribution to journalJournal articleResearchpeer-review

18 Citations (Scopus)

Abstract

INTRODUCTION: The purpose of this study was to test a hypothesis of increased urinary excretion of uric acid as an indicator of adenosine triphosphate (ATP) degradation in adult patients with acute respiratory failure, and to look for a correlation to the clinical outcome.

STUDY DESIGN: Prospectively 31 patients with acute respiratory failure were studied. The patients were divided into two groups according to the clinical outcome: the need for solely supplemental oxygen (group 1), death or mechanical ventilation (group 2).

METHODS: Uric acid was determined by spectrophotometry.

RESULTS: Mean uric acid excretion was 39 mumol/kg (range, 7 to 92 mumol/kg) body weight/per 24 h in group 1 (16 patients) compared with 65 mumol/kg/24 h (range, 8 to 253 mumol/kg/24 h) in group 2 (13 patients were mechanically ventilated, and two patients died). The difference was highly significant (p less than 0.0001).

CONCLUSION: Increased amount of urinary uric acid was related to the severity of acute respiratory failure in adults.

Original languageEnglish
JournalChest
Volume102
Issue number2
Pages (from-to)556-559
Number of pages4
ISSN0012-3692
DOIs
Publication statusPublished - 1992
Externally publishedYes

Keywords

  • Acute Disease
  • Analysis of Variance
  • Female
  • Humans
  • Intensive Care
  • Male
  • Prospective Studies
  • Respiration, Artificial
  • Respiratory Insufficiency
  • Treatment Outcome
  • Uric Acid

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