Abstract
INTRODUCTION: The purpose of this study was to test a hypothesis of increased urinary excretion of uric acid as an indicator of adenosine triphosphate (ATP) degradation in adult patients with acute respiratory failure, and to look for a correlation to the clinical outcome.
STUDY DESIGN: Prospectively 31 patients with acute respiratory failure were studied. The patients were divided into two groups according to the clinical outcome: the need for solely supplemental oxygen (group 1), death or mechanical ventilation (group 2).
METHODS: Uric acid was determined by spectrophotometry.
RESULTS: Mean uric acid excretion was 39 mumol/kg (range, 7 to 92 mumol/kg) body weight/per 24 h in group 1 (16 patients) compared with 65 mumol/kg/24 h (range, 8 to 253 mumol/kg/24 h) in group 2 (13 patients were mechanically ventilated, and two patients died). The difference was highly significant (p less than 0.0001).
CONCLUSION: Increased amount of urinary uric acid was related to the severity of acute respiratory failure in adults.
Original language | English |
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Journal | Chest |
Volume | 102 |
Issue number | 2 |
Pages (from-to) | 556-559 |
Number of pages | 4 |
ISSN | 0012-3692 |
DOIs | |
Publication status | Published - 1992 |
Externally published | Yes |
Keywords
- Acute Disease
- Analysis of Variance
- Female
- Humans
- Intensive Care
- Male
- Prospective Studies
- Respiration, Artificial
- Respiratory Insufficiency
- Treatment Outcome
- Uric Acid