Induction of GLUT-1 protein in adult human skeletal muscle fibers

M. Gaster*, J. Franch, P. Staehr, H. Beck-Nielsen, T. Smith, H. D. Schrøder

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

16 Citations (Scopus)

Abstract

Prompted by our recent observations that GLUT-1 is expressed in fetal muscles, but not in adult muscle fibers, we decided to investigate whether GLUT-1 expression could be reactivated. We studied different stimuli concerning their ability to induce GLUT-1 expression in mature human skeletal muscle fibers. Metabolic stress (obesity, non-insulin-dependent diabetes mellitus), contractile activity (training), and conditions of de- and reinnervation (amyotrophic lateral sclerosis) could not induce GLUT-1 expression in human muscle fibers. However, regenerating muscle fibers in polymyositis expressed GLUT-1. In contrast to GLUT-1, GLUT-4 was expressed in all investigated muscle fibers. Although the significance of GLUT-1 in adult human muscle fibers appears limited, GLUT-1 may be of importance for the glucose supplies in immature and regenerating muscle.

Original languageEnglish
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume279
Issue number5 42-5
Pages (from-to)E1191-E1195
ISSN0193-1849
DOIs
Publication statusPublished - 2000

Keywords

  • Immunocytochemistry
  • Non-insulin-dependent diabetes mellitus
  • Obesity
  • Regeneration
  • Skeletal muscle

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