Abstract
Prompted by our recent observations that GLUT-1 is expressed in fetal muscles, but not in adult muscle fibers, we decided to investigate whether GLUT-1 expression could be reactivated. We studied different stimuli concerning their ability to induce GLUT-1 expression in mature human skeletal muscle fibers. Metabolic stress (obesity, non-insulin-dependent diabetes mellitus), contractile activity (training), and conditions of de- and reinnervation (amyotrophic lateral sclerosis) could not induce GLUT-1 expression in human muscle fibers. However, regenerating muscle fibers in polymyositis expressed GLUT-1. In contrast to GLUT-1, GLUT-4 was expressed in all investigated muscle fibers. Although the significance of GLUT-1 in adult human muscle fibers appears limited, GLUT-1 may be of importance for the glucose supplies in immature and regenerating muscle.
Original language | English |
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Journal | American Journal of Physiology - Endocrinology and Metabolism |
Volume | 279 |
Issue number | 5 42-5 |
Pages (from-to) | E1191-E1195 |
ISSN | 0193-1849 |
DOIs | |
Publication status | Published - 2000 |
Keywords
- Immunocytochemistry
- Non-insulin-dependent diabetes mellitus
- Obesity
- Regeneration
- Skeletal muscle