Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans

Kally Z Pan, Julia E Palter, Aric N Rogers, Anders Olsen, Di Chen, Gordon J Lithgow, Pankaj Kapahi

Research output: Contribution to journalJournal articleResearchpeer-review

209 Citations (Scopus)


Protein synthesis is a regulated cellular process that links nutrients in the environment to organismal growth and development. Here we examine the role of genes that regulate mRNA translation in determining growth, reproduction, stress resistance and lifespan. Translational control of protein synthesis by regulators such as the cap-binding complex and S6 kinase play an important role during growth. We observe that inhibition of various genes in the translation initiation complex including ifg-1, the worm homologue of eIF4G, which is a scaffold protein in the cap-binding complex; and rsks-1, the worm homologue of S6 kinase, results in lifespan extension in Caenorhabditis elegans. Inhibition of ifg-1 or rsks-1 also slows development, reduces fecundity and increases resistance to starvation. A reduction in ifg-1 expression in dauers was also observed, suggesting an inhibition of protein translation during the dauer state. Thus, mRNA translation exerts pleiotropic effects on growth, reproduction, stress resistance and lifespan in C. elegans.

Original languageEnglish
JournalAging Cell
Issue number1
Pages (from-to)111-9
Number of pages9
Publication statusPublished - Feb 2007
Externally publishedYes


  • Animals
  • Caenorhabditis elegans/genetics
  • Caenorhabditis elegans Proteins/biosynthesis
  • Eukaryotic Initiation Factor-4G
  • Gene Expression Regulation, Developmental/genetics
  • Growth/genetics
  • Immunity, Innate/genetics
  • Longevity/genetics
  • Peptide Fragments/genetics
  • Peptide Initiation Factors/genetics
  • Protein Biosynthesis/genetics
  • Reproduction/genetics
  • Ribosomal Protein S6 Kinases/genetics
  • Ribosomal Protein S6 Kinases, 70-kDa/biosynthesis
  • Saccharomyces cerevisiae Proteins
  • Stress, Physiological/genetics
  • Survival Rate


Dive into the research topics of 'Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans'. Together they form a unique fingerprint.

Cite this