Interaction between shift work and established coronary risk factors

Jonas Hermanson, Henrik Bøggild, Johan Hallqvist, Berndt Karlsson, Anders Knutsson, Tohr Nilsson, Christina Reuterwall, Katja Gillander Gådin

Research output: Contribution to journalJournal articleResearchpeer-review

1 Citation (Scopus)
9 Downloads (Pure)

Abstract

Background: Shift work is associated with increased risk of cardiovascular disease, but the causes have not yet been fully established. It has been proposed that the coronary risk factors are more hazardous for shift workers, resulting in a potential interaction effect with shift work. Objective: To analyse interaction effects of work schedule and established risk factors for coronary artery disease on the risk of myocardial infarction. Methods: This analysis was conducted in SHEEP/VHEEP, a case-control study conducted in two counties in Sweden, comprising all first-time cases of myocardial infarction among men and women 45–70 years of age with controls stratified by sex, age, and hospital catchment area, totalling to 4648 participants. Synergy index (SI) was used as the main outcome analysis method for interaction analysis. Results: There was an interaction effect between shift work and physical inactivity on the risk of myocardial infarction with SI of 2.05 (95% CI 1.07 to 3.92) for male shift workers. For female shift workers, interaction effects were found with high waist-hip ratio (SI 4.0, 95% CI 1.12 to 14.28) and elevated triglycerides (SI 5.69, 95% CI 1.67 to 19.38). Conclusion: Shift work and some established coronary risk factors have significant interactions.

Original languageEnglish
JournalInternational Journal of Occupational and Environmental Medicine
Volume10
Issue number2
Pages (from-to)57-65
Number of pages9
ISSN2008-6520
DOIs
Publication statusPublished - Apr 2019

Keywords

  • Cardiovascular diseases
  • Epidemiology
  • Risk factors
  • Shift work schedule
  • Synergy

Fingerprint Dive into the research topics of 'Interaction between shift work and established coronary risk factors'. Together they form a unique fingerprint.

Cite this