TY - JOUR
T1 - Intralesional methotrexate in dermatology
T2 - diverse indications and practical considerations
AU - Searle, Tamara
AU - Ali, Faisal R
AU - Al-Niaimi, Firas
N1 - © 2020 Wiley Periodicals LLC.
PY - 2021/2
Y1 - 2021/2
N2 - Intralesional methotrexate (IL-MTX) is a long-established treatment, which is arguably underutilized by dermatologists. We describe the underlying evidence base and practical considerations for its broad range of cutaneous indications, including in cutaneous oncology (keratoacanthomas, squamous cell carcinomas, lymphomas), inflammatory dermatology (nail psoriasis, plaque psoriasis, pyoderma gangrenosum, cutaneous Crohn's disease, amyloidosis), cutaneous infections (viral warts) and for treatment of filler complications. In certain circumstances, IL-MTX can be more efficacious and less invasive than other treatments, with fewer adverse effects. Dermatologists should consider using IL-MTX for a range of recalcitrant cutaneous conditions, particularly for those patients not amenable to surgery or systemic therapy.
AB - Intralesional methotrexate (IL-MTX) is a long-established treatment, which is arguably underutilized by dermatologists. We describe the underlying evidence base and practical considerations for its broad range of cutaneous indications, including in cutaneous oncology (keratoacanthomas, squamous cell carcinomas, lymphomas), inflammatory dermatology (nail psoriasis, plaque psoriasis, pyoderma gangrenosum, cutaneous Crohn's disease, amyloidosis), cutaneous infections (viral warts) and for treatment of filler complications. In certain circumstances, IL-MTX can be more efficacious and less invasive than other treatments, with fewer adverse effects. Dermatologists should consider using IL-MTX for a range of recalcitrant cutaneous conditions, particularly for those patients not amenable to surgery or systemic therapy.
KW - Intralesional
KW - Keratoacanthoma
KW - methotrexate
KW - squamous cell carcinoma
KW - warts
UR - http://www.scopus.com/inward/record.url?scp=85092763318&partnerID=8YFLogxK
U2 - 10.1111/dth.14404
DO - 10.1111/dth.14404
M3 - Review article
C2 - 33044042
SN - 1396-0296
VL - 34
JO - Dermatologic Therapy
JF - Dermatologic Therapy
IS - 1
M1 - e14404
ER -