Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe: the TropNet Severe Malaria Study

Florian Kurth; Michel Develoux; Matthieu Mechain; Jan Clerinx; Spinello Antinori; Ida E Gjørup; Joaquím Gascon; Kristine Mørch; Emanuele Nicastri; Michael Ramharter; Alessandro Bartoloni; Leo Visser; Thierry Rolling; Philipp Zanger; Guido Calleri; Joaquín Salas-Coronas; Henrik Ib Nielsen; Gudrun Just-Nübling; Andreas Neumayr; Anna Hachfeld; Matthias L Schmid; Pietro Antonini; Peter Pongratz; Peter Kern; José Saraiva da Cunha; Antoni Soriano-Arandes; Mirjam Schunk; Norbert Suttorp; Christoph Hatz; Thomas Zoller; Tropnet Severe Malaria Investigator Group

doi:10.1093/cid/civ575

Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe: the TropNet Severe Malaria Study

Florian Kurth, Michel Develoux, Matthieu Mechain, Jan Clerinx, Spinello Antinori, Ida E Gjørup, Joaquím Gascon, Kristine Mørch, Emanuele Nicastri, Michael Ramharter, Alessandro Bartoloni, Leo Visser, Thierry Rolling, Philipp Zanger, Guido Calleri, Joaquín Salas-Coronas, Henrik Ib Nielsen, Gudrun Just-Nübling, Andreas Neumayr, Anna HachfeldMatthias L Schmid, Pietro Antonini, Peter Pongratz, Peter Kern, José Saraiva da Cunha, Antoni Soriano-Arandes, Mirjam Schunk, Norbert Suttorp, Christoph Hatz, Thomas Zoller, Tropnet Severe Malaria Investigator Group

Research output: Contribution to journal › Journal article › Research › peer-review

38 Citations (Scopus)

Abstract

Intravenous artesunate improves survival in severe malaria, but clinical trial data from non-endemic countries are scarce. The TropNet severe malaria database was analyzed to compare outcomes of artesunate vs. quinine treatment. Artesunate reduced parasite clearance time, duration of ICU- and hospital treatment in European patients with imported severe malaria.

Original language	English
Journal	Clinical Infectious Diseases
Volume	61
Issue number	9
Pages (from-to)	1441-1444
Number of pages	4
ISSN	1058-4838
DOIs	https://doi.org/10.1093/cid/civ575
Publication status	Published - 2015

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Kurth, F., Develoux, M., Mechain, M., Clerinx, J., Antinori, S., Gjørup, I. E., Gascon, J., Mørch, K., Nicastri, E., Ramharter, M., Bartoloni, A., Visser, L., Rolling, T., Zanger, P., Calleri, G., Salas-Coronas, J., Nielsen, H. I., Just-Nübling, G., Neumayr, A., ... Tropnet Severe Malaria Investigator Group (2015). Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe: the TropNet Severe Malaria Study. Clinical Infectious Diseases, 61(9), 1441-1444. https://doi.org/10.1093/cid/civ575

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title = "Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe: the TropNet Severe Malaria Study",

abstract = "Intravenous artesunate improves survival in severe malaria, but clinical trial data from non-endemic countries are scarce. The TropNet severe malaria database was analyzed to compare outcomes of artesunate vs. quinine treatment. Artesunate reduced parasite clearance time, duration of ICU- and hospital treatment in European patients with imported severe malaria.",

author = "Florian Kurth and Michel Develoux and Matthieu Mechain and Jan Clerinx and Spinello Antinori and Gj{\o}rup, {Ida E} and Joaqu{\'i}m Gascon and Kristine M{\o}rch and Emanuele Nicastri and Michael Ramharter and Alessandro Bartoloni and Leo Visser and Thierry Rolling and Philipp Zanger and Guido Calleri and Joaqu{\'i}n Salas-Coronas and Nielsen, {Henrik Ib} and Gudrun Just-N{\"u}bling and Andreas Neumayr and Anna Hachfeld and Schmid, {Matthias L} and Pietro Antonini and Peter Pongratz and Peter Kern and {Saraiva da Cunha}, Jos{\'e} and Antoni Soriano-Arandes and Mirjam Schunk and Norbert Suttorp and Christoph Hatz and Thomas Zoller and {Tropnet Severe Malaria Investigator Group}",

note = "{\textcopyright} The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.",

year = "2015",

doi = "10.1093/cid/civ575",

language = "English",

volume = "61",

pages = "1441--1444",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "9",

}

Kurth, F, Develoux, M, Mechain, M, Clerinx, J, Antinori, S, Gjørup, IE, Gascon, J, Mørch, K, Nicastri, E, Ramharter, M, Bartoloni, A, Visser, L, Rolling, T, Zanger, P, Calleri, G, Salas-Coronas, J, Nielsen, HI, Just-Nübling, G, Neumayr, A, Hachfeld, A, Schmid, ML, Antonini, P, Pongratz, P, Kern, P, Saraiva da Cunha, J, Soriano-Arandes, A, Schunk, M, Suttorp, N, Hatz, C, Zoller, T & Tropnet Severe Malaria Investigator Group 2015, 'Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe: the TropNet Severe Malaria Study', Clinical Infectious Diseases, vol. 61, no. 9, pp. 1441-1444. https://doi.org/10.1093/cid/civ575

Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe: the TropNet Severe Malaria Study. / Kurth, Florian; Develoux, Michel; Mechain, Matthieu et al.
In: Clinical Infectious Diseases, Vol. 61, No. 9, 2015, p. 1441-1444.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe

T2 - the TropNet Severe Malaria Study

AU - Kurth, Florian

AU - Develoux, Michel

AU - Mechain, Matthieu

AU - Clerinx, Jan

AU - Antinori, Spinello

AU - Gjørup, Ida E

AU - Gascon, Joaquím

AU - Mørch, Kristine

AU - Nicastri, Emanuele

AU - Ramharter, Michael

AU - Bartoloni, Alessandro

AU - Visser, Leo

AU - Rolling, Thierry

AU - Zanger, Philipp

AU - Calleri, Guido

AU - Salas-Coronas, Joaquín

AU - Nielsen, Henrik Ib

AU - Just-Nübling, Gudrun

AU - Neumayr, Andreas

AU - Hachfeld, Anna

AU - Schmid, Matthias L

AU - Antonini, Pietro

AU - Pongratz, Peter

AU - Kern, Peter

AU - Saraiva da Cunha, José

AU - Soriano-Arandes, Antoni

AU - Schunk, Mirjam

AU - Suttorp, Norbert

AU - Hatz, Christoph

AU - Zoller, Thomas

AU - Tropnet Severe Malaria Investigator Group

PY - 2015

Y1 - 2015

N2 - Intravenous artesunate improves survival in severe malaria, but clinical trial data from non-endemic countries are scarce. The TropNet severe malaria database was analyzed to compare outcomes of artesunate vs. quinine treatment. Artesunate reduced parasite clearance time, duration of ICU- and hospital treatment in European patients with imported severe malaria.

AB - Intravenous artesunate improves survival in severe malaria, but clinical trial data from non-endemic countries are scarce. The TropNet severe malaria database was analyzed to compare outcomes of artesunate vs. quinine treatment. Artesunate reduced parasite clearance time, duration of ICU- and hospital treatment in European patients with imported severe malaria.

U2 - 10.1093/cid/civ575

DO - 10.1093/cid/civ575

M3 - Journal article

C2 - 26187021

SN - 1058-4838

VL - 61

SP - 1441

EP - 1444

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 9

ER -

Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe: the TropNet Severe Malaria Study

Abstract

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