Irreversible electroporation of pancreatic cancer - Effect on quality of life and pain perception

Rasmus Virenfeldt Flak; Molly Maine Malmberg; Mogens Tornby Stender; Ann Hauberg; Ole Thorlacius-Ussing

doi:10.1016/j.pan.2021.04.011

Irreversible electroporation of pancreatic cancer - Effect on quality of life and pain perception

Rasmus Virenfeldt Flak^*, Molly Maine Malmberg, Mogens Tornby Stender, Ann Hauberg, Ole Thorlacius-Ussing

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

Abstract

BACKGROUND: Most pancreatic cancer (PC) patients are incurable and may need palliative treatment at some point in time. Irreversible electroporation (IRE) is a novel ablative treatment, which aims to provide local tumor control. The aim of this study was to examine how consolidative treatment with IRE affects quality of life (QOL) and pain perception (PP) in patients with non-metastatic pancreatic cancer.

METHODS: Secondary outcomes were extracted from a prospective cohort of non-metastatic PC patients treated with IRE from 2013 to 2019. Patients filled in two questionnaires examining QOL and PP at different timepoints during treatment and follow-up. Data from a selected panel of subscales were extracted and analyzed using a mixed random intercept regression model.

RESULTS: Subscales from 41 patients at four different timepoints were included in the model. Global health status, physical functioning, fatigue, nausea and vomiting, appetite loss and mean pain interference were negatively impacted (p < 0.05) in the short- and mid-term, corresponding to a low or moderate clinical effect size. However, all negative effects showed a tendency to dissipate over time.

CONCLUSIONS: IRE treatment negatively impacted QOL and PP in the short- and mid-term. No positive long-term effects of IRE were found.

Original language	English
Journal	Pancreatology
Volume	21
Issue number	6
Pages (from-to)	1059-1063
Number of pages	5
ISSN	1424-3903
DOIs	https://doi.org/10.1016/j.pan.2021.04.011
Publication status	Published - Sept 2021

Bibliographical note

Keywords

Ablation techniques
Electroporation
Pain management
Pancreatic neoplasms
Quality of life

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@article{8b386ab2350a4b128abcc804e9313592,

title = "Irreversible electroporation of pancreatic cancer - Effect on quality of life and pain perception",

abstract = "BACKGROUND: Most pancreatic cancer (PC) patients are incurable and may need palliative treatment at some point in time. Irreversible electroporation (IRE) is a novel ablative treatment, which aims to provide local tumor control. The aim of this study was to examine how consolidative treatment with IRE affects quality of life (QOL) and pain perception (PP) in patients with non-metastatic pancreatic cancer.METHODS: Secondary outcomes were extracted from a prospective cohort of non-metastatic PC patients treated with IRE from 2013 to 2019. Patients filled in two questionnaires examining QOL and PP at different timepoints during treatment and follow-up. Data from a selected panel of subscales were extracted and analyzed using a mixed random intercept regression model.RESULTS: Subscales from 41 patients at four different timepoints were included in the model. Global health status, physical functioning, fatigue, nausea and vomiting, appetite loss and mean pain interference were negatively impacted (p < 0.05) in the short- and mid-term, corresponding to a low or moderate clinical effect size. However, all negative effects showed a tendency to dissipate over time.CONCLUSIONS: IRE treatment negatively impacted QOL and PP in the short- and mid-term. No positive long-term effects of IRE were found.",

keywords = "Ablation techniques, Electroporation, Pain management, Pancreatic neoplasms, Quality of life",

author = "Flak, {Rasmus Virenfeldt} and Malmberg, {Molly Maine} and Stender, {Mogens Tornby} and Ann Hauberg and Ole Thorlacius-Ussing",

year = "2021",

month = sep,

doi = "10.1016/j.pan.2021.04.011",

language = "English",

volume = "21",

pages = "1059--1063",

journal = "Pancreatology",

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T1 - Irreversible electroporation of pancreatic cancer - Effect on quality of life and pain perception

AU - Flak, Rasmus Virenfeldt

AU - Malmberg, Molly Maine

AU - Stender, Mogens Tornby

AU - Hauberg, Ann

AU - Thorlacius-Ussing, Ole

PY - 2021/9

Y1 - 2021/9

N2 - BACKGROUND: Most pancreatic cancer (PC) patients are incurable and may need palliative treatment at some point in time. Irreversible electroporation (IRE) is a novel ablative treatment, which aims to provide local tumor control. The aim of this study was to examine how consolidative treatment with IRE affects quality of life (QOL) and pain perception (PP) in patients with non-metastatic pancreatic cancer.METHODS: Secondary outcomes were extracted from a prospective cohort of non-metastatic PC patients treated with IRE from 2013 to 2019. Patients filled in two questionnaires examining QOL and PP at different timepoints during treatment and follow-up. Data from a selected panel of subscales were extracted and analyzed using a mixed random intercept regression model.RESULTS: Subscales from 41 patients at four different timepoints were included in the model. Global health status, physical functioning, fatigue, nausea and vomiting, appetite loss and mean pain interference were negatively impacted (p < 0.05) in the short- and mid-term, corresponding to a low or moderate clinical effect size. However, all negative effects showed a tendency to dissipate over time.CONCLUSIONS: IRE treatment negatively impacted QOL and PP in the short- and mid-term. No positive long-term effects of IRE were found.

AB - BACKGROUND: Most pancreatic cancer (PC) patients are incurable and may need palliative treatment at some point in time. Irreversible electroporation (IRE) is a novel ablative treatment, which aims to provide local tumor control. The aim of this study was to examine how consolidative treatment with IRE affects quality of life (QOL) and pain perception (PP) in patients with non-metastatic pancreatic cancer.METHODS: Secondary outcomes were extracted from a prospective cohort of non-metastatic PC patients treated with IRE from 2013 to 2019. Patients filled in two questionnaires examining QOL and PP at different timepoints during treatment and follow-up. Data from a selected panel of subscales were extracted and analyzed using a mixed random intercept regression model.RESULTS: Subscales from 41 patients at four different timepoints were included in the model. Global health status, physical functioning, fatigue, nausea and vomiting, appetite loss and mean pain interference were negatively impacted (p < 0.05) in the short- and mid-term, corresponding to a low or moderate clinical effect size. However, all negative effects showed a tendency to dissipate over time.CONCLUSIONS: IRE treatment negatively impacted QOL and PP in the short- and mid-term. No positive long-term effects of IRE were found.

KW - Ablation techniques

KW - Electroporation

KW - Pain management

KW - Pancreatic neoplasms

KW - Quality of life

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DO - 10.1016/j.pan.2021.04.011

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SN - 1424-3903

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JO - Pancreatology

JF - Pancreatology

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ER -

Irreversible electroporation of pancreatic cancer - Effect on quality of life and pain perception

Abstract

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Keywords

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