Is structural hydroxyapatite tricalcium-phosphate graft or tricortical iliac crest autograft better for calcaneal lengthening osteotomy in childhood?: interim results from a randomised, controlled non-inferiority study

P Martinkevich; Ole Rahbek; M Stilling; L K Pedersen; M Gottliebsen; K Søballe; B Møller-Madsen

doi:10.1302/0301-620X.98B11.BJJ-2016-0095.R1

Is structural hydroxyapatite tricalcium-phosphate graft or tricortical iliac crest autograft better for calcaneal lengthening osteotomy in childhood? interim results from a randomised, controlled non-inferiority study

P Martinkevich, Ole Rahbek, M Stilling, L K Pedersen, M Gottliebsen, K Søballe, B Møller-Madsen

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Abstract

AIMS: To compare the structural durability of hydroxyapatite-tricalcium phosphate (HATCP) to autologous iliac crest bone graft in calcaneal lengthening osteotomy (CLO) for pes planovalgus in childhood.

PATIENTS AND METHODS: We present the interim results of ten patients (HATCP, n = 6 and autograft, n = 5) with a mean age of 11.5 years (8.2 to 14.2) from a randomised controlled non-inferiority trial with six months follow-up. The primary outcome was the stability of the osteotomy as measured by radiostereometric analysis. A non-inferiority margin of ≤ 2 mm osteotomy compression was set.

RESULTS: At six months the data showed that the osteotomy had been compressed by a mean 1.97 mm (99.8% confidence interval -1.65 to 5.60) more in the HATCP group than in the autograft group. Migration of the CLO grafted with HATCP stabilised at six months rather than at six weeks with autograft.

CONCLUSION: This is the first randomised trial to compare the efficacy of HATCP graft with autograft in terms of stability of CLO in children. Because of problems with the HATCP the trial was stopped. We do not recommend HATCP graft in its current structure for use in unfixed CLOs. Cite this article: Bone Joint J 2016;98-B:1554-62.

Original language	English
Journal	Journal of Bone and Joint Surgery: British Volume
Volume	98-B
Issue number	11
Pages (from-to)	1554-1562
Number of pages	9
ISSN	2049-4394
DOIs	https://doi.org/10.1302/0301-620X.98B11.BJJ-2016-0095.R1
Publication status	Published - Nov 2016
Externally published	Yes

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Martinkevich, P., Rahbek, O., Stilling, M., Pedersen, L. K., Gottliebsen, M., Søballe, K., & Møller-Madsen, B. (2016). Is structural hydroxyapatite tricalcium-phosphate graft or tricortical iliac crest autograft better for calcaneal lengthening osteotomy in childhood? interim results from a randomised, controlled non-inferiority study. Journal of Bone and Joint Surgery: British Volume, 98-B(11), 1554-1562. https://doi.org/10.1302/0301-620X.98B11.BJJ-2016-0095.R1

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title = "Is structural hydroxyapatite tricalcium-phosphate graft or tricortical iliac crest autograft better for calcaneal lengthening osteotomy in childhood?: interim results from a randomised, controlled non-inferiority study",

abstract = "AIMS: To compare the structural durability of hydroxyapatite-tricalcium phosphate (HATCP) to autologous iliac crest bone graft in calcaneal lengthening osteotomy (CLO) for pes planovalgus in childhood.PATIENTS AND METHODS: We present the interim results of ten patients (HATCP, n = 6 and autograft, n = 5) with a mean age of 11.5 years (8.2 to 14.2) from a randomised controlled non-inferiority trial with six months follow-up. The primary outcome was the stability of the osteotomy as measured by radiostereometric analysis. A non-inferiority margin of ≤ 2 mm osteotomy compression was set.RESULTS: At six months the data showed that the osteotomy had been compressed by a mean 1.97 mm (99.8% confidence interval -1.65 to 5.60) more in the HATCP group than in the autograft group. Migration of the CLO grafted with HATCP stabilised at six months rather than at six weeks with autograft.CONCLUSION: This is the first randomised trial to compare the efficacy of HATCP graft with autograft in terms of stability of CLO in children. Because of problems with the HATCP the trial was stopped. We do not recommend HATCP graft in its current structure for use in unfixed CLOs. Cite this article: Bone Joint J 2016;98-B:1554-62.",

author = "P Martinkevich and Ole Rahbek and M Stilling and Pedersen, {L K} and M Gottliebsen and K S{\o}balle and B M{\o}ller-Madsen",

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Martinkevich, P, Rahbek, O, Stilling, M, Pedersen, LK, Gottliebsen, M, Søballe, K & Møller-Madsen, B 2016, 'Is structural hydroxyapatite tricalcium-phosphate graft or tricortical iliac crest autograft better for calcaneal lengthening osteotomy in childhood? interim results from a randomised, controlled non-inferiority study', Journal of Bone and Joint Surgery: British Volume, vol. 98-B, no. 11, pp. 1554-1562. https://doi.org/10.1302/0301-620X.98B11.BJJ-2016-0095.R1

Is structural hydroxyapatite tricalcium-phosphate graft or tricortical iliac crest autograft better for calcaneal lengthening osteotomy in childhood? interim results from a randomised, controlled non-inferiority study. / Martinkevich, P; Rahbek, Ole; Stilling, M et al.
In: Journal of Bone and Joint Surgery: British Volume, Vol. 98-B, No. 11, 11.2016, p. 1554-1562.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Is structural hydroxyapatite tricalcium-phosphate graft or tricortical iliac crest autograft better for calcaneal lengthening osteotomy in childhood?

T2 - interim results from a randomised, controlled non-inferiority study

AU - Martinkevich, P

AU - Rahbek, Ole

AU - Stilling, M

AU - Pedersen, L K

AU - Gottliebsen, M

AU - Søballe, K

AU - Møller-Madsen, B

PY - 2016/11

Y1 - 2016/11

N2 - AIMS: To compare the structural durability of hydroxyapatite-tricalcium phosphate (HATCP) to autologous iliac crest bone graft in calcaneal lengthening osteotomy (CLO) for pes planovalgus in childhood.PATIENTS AND METHODS: We present the interim results of ten patients (HATCP, n = 6 and autograft, n = 5) with a mean age of 11.5 years (8.2 to 14.2) from a randomised controlled non-inferiority trial with six months follow-up. The primary outcome was the stability of the osteotomy as measured by radiostereometric analysis. A non-inferiority margin of ≤ 2 mm osteotomy compression was set.RESULTS: At six months the data showed that the osteotomy had been compressed by a mean 1.97 mm (99.8% confidence interval -1.65 to 5.60) more in the HATCP group than in the autograft group. Migration of the CLO grafted with HATCP stabilised at six months rather than at six weeks with autograft.CONCLUSION: This is the first randomised trial to compare the efficacy of HATCP graft with autograft in terms of stability of CLO in children. Because of problems with the HATCP the trial was stopped. We do not recommend HATCP graft in its current structure for use in unfixed CLOs. Cite this article: Bone Joint J 2016;98-B:1554-62.

AB - AIMS: To compare the structural durability of hydroxyapatite-tricalcium phosphate (HATCP) to autologous iliac crest bone graft in calcaneal lengthening osteotomy (CLO) for pes planovalgus in childhood.PATIENTS AND METHODS: We present the interim results of ten patients (HATCP, n = 6 and autograft, n = 5) with a mean age of 11.5 years (8.2 to 14.2) from a randomised controlled non-inferiority trial with six months follow-up. The primary outcome was the stability of the osteotomy as measured by radiostereometric analysis. A non-inferiority margin of ≤ 2 mm osteotomy compression was set.RESULTS: At six months the data showed that the osteotomy had been compressed by a mean 1.97 mm (99.8% confidence interval -1.65 to 5.60) more in the HATCP group than in the autograft group. Migration of the CLO grafted with HATCP stabilised at six months rather than at six weeks with autograft.CONCLUSION: This is the first randomised trial to compare the efficacy of HATCP graft with autograft in terms of stability of CLO in children. Because of problems with the HATCP the trial was stopped. We do not recommend HATCP graft in its current structure for use in unfixed CLOs. Cite this article: Bone Joint J 2016;98-B:1554-62.

U2 - 10.1302/0301-620X.98B11.BJJ-2016-0095.R1

DO - 10.1302/0301-620X.98B11.BJJ-2016-0095.R1

M3 - Journal article

C2 - 27803234

SN - 2049-4394

VL - 98-B

SP - 1554

EP - 1562

JO - Journal of Bone and Joint Surgery: British Volume

JF - Journal of Bone and Joint Surgery: British Volume

IS - 11

ER -

Martinkevich P, Rahbek O, Stilling M, Pedersen LK, Gottliebsen M, Søballe K et al. Is structural hydroxyapatite tricalcium-phosphate graft or tricortical iliac crest autograft better for calcaneal lengthening osteotomy in childhood? interim results from a randomised, controlled non-inferiority study. Journal of Bone and Joint Surgery: British Volume. 2016 Nov;98-B(11):1554-1562. doi: 10.1302/0301-620X.98B11.BJJ-2016-0095.R1