Leverbiopsi hos leverpatienter med koagulopati

Peter Ott, Henning Grønbaek, Jens Otto Clemmesen, Mette Rye Clausen, André Wettergren, Troels Havelund, Erik Feldager, Flemming Bendtsen, Bent Adel Hansen, Ulrik Tage-Jensen, Lars P.S. Larsen, Hendrik Vilstrup

Research output: Contribution to journalJournal articlepeer-review

3 Citations (Scopus)

Abstract

The risk of severe bleeding after liver biopsy is estimated to be 1:12,000 in patients with near normal coagulation (INR < 1,5 and platelet count > 60 billion /l). Beyond these limits, the risk is higher, but still uncertain. The Danish guidelines require INR > 1.5, platelet count < 40 billion /l and normal APTT. In some instances the risk of not knowing the histology is so high that a biopsy is considered even with a more disturbed coagulation. Vitamin K, freshly frozen plasma and recombinant activated factor VII may reduce the risk of bleeding in specific situations, but no firm recommendations can be given.
Udgivelsesdato: 2008-Nov-3
Original languageDanish
Volume170
Pages (from-to)3671-3
Number of pages2
ISSN0041-5782
Publication statusPublished - 2008
Externally publishedYes

Keywords

  • Biopsy
  • Blood Coagulation Disorders
  • Hemorrhage
  • Humans
  • International Normalized Ratio
  • Liver
  • Liver Diseases
  • Platelet Count
  • Risk Factors

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