Leverbiopsi hos leverpatienter med koagulopati

Peter Ott; Henning Grønbaek; Jens Otto Clemmesen; Mette Rye Clausen; André Wettergren; Troels Havelund; Erik Feldager; Flemming Bendtsen; Bent Adel Hansen; Ulrik Tage-Jensen; Lars P.S. Larsen; Hendrik Vilstrup

Leverbiopsi hos leverpatienter med koagulopati

Peter Ott, Henning Grønbaek, Jens Otto Clemmesen, Mette Rye Clausen, André Wettergren, Troels Havelund, Erik Feldager, Flemming Bendtsen, Bent Adel Hansen, Ulrik Tage-Jensen, Lars P.S. Larsen, Hendrik Vilstrup

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Abstract

The risk of severe bleeding after liver biopsy is estimated to be 1:12,000 in patients with near normal coagulation (INR < 1,5 and platelet count > 60 billion /l). Beyond these limits, the risk is higher, but still uncertain. The Danish guidelines require INR > 1.5, platelet count < 40 billion /l and normal APTT. In some instances the risk of not knowing the histology is so high that a biopsy is considered even with a more disturbed coagulation. Vitamin K, freshly frozen plasma and recombinant activated factor VII may reduce the risk of bleeding in specific situations, but no firm recommendations can be given.
Udgivelsesdato: 2008-Nov-3

Original language	Danish
Volume	170
Pages (from-to)	3671-3
Number of pages	2
ISSN	0041-5782
Publication status	Published - 2008
Externally published	Yes

Keywords

Biopsy
Blood Coagulation Disorders
Hemorrhage
Humans
International Normalized Ratio
Liver
Liver Diseases
Platelet Count
Risk Factors

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Cite this

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title = "Leverbiopsi hos leverpatienter med koagulopati",

abstract = "The risk of severe bleeding after liver biopsy is estimated to be 1:12,000 in patients with near normal coagulation (INR < 1,5 and platelet count > 60 billion /l). Beyond these limits, the risk is higher, but still uncertain. The Danish guidelines require INR > 1.5, platelet count < 40 billion /l and normal APTT. In some instances the risk of not knowing the histology is so high that a biopsy is considered even with a more disturbed coagulation. Vitamin K, freshly frozen plasma and recombinant activated factor VII may reduce the risk of bleeding in specific situations, but no firm recommendations can be given. Udgivelsesdato: 2008-Nov-3",

keywords = "Biopsy, Blood Coagulation Disorders, Hemorrhage, Humans, International Normalized Ratio, Liver, Liver Diseases, Platelet Count, Risk Factors",

author = "Peter Ott and Henning Gr{\o}nbaek and Clemmesen, {Jens Otto} and Clausen, {Mette Rye} and Andr{\'e} Wettergren and Troels Havelund and Erik Feldager and Flemming Bendtsen and Hansen, {Bent Adel} and Ulrik Tage-Jensen and Larsen, {Lars P.S.} and Hendrik Vilstrup",

year = "2008",

language = "Dansk",

volume = "170",

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publisher = "Almindelige Danske Laegeforening",

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TY - JOUR

T1 - Leverbiopsi hos leverpatienter med koagulopati

AU - Ott, Peter

AU - Grønbaek, Henning

AU - Clemmesen, Jens Otto

AU - Clausen, Mette Rye

AU - Wettergren, André

AU - Havelund, Troels

AU - Feldager, Erik

AU - Bendtsen, Flemming

AU - Hansen, Bent Adel

AU - Tage-Jensen, Ulrik

AU - Larsen, Lars P.S.

AU - Vilstrup, Hendrik

PY - 2008

Y1 - 2008

N2 - The risk of severe bleeding after liver biopsy is estimated to be 1:12,000 in patients with near normal coagulation (INR < 1,5 and platelet count > 60 billion /l). Beyond these limits, the risk is higher, but still uncertain. The Danish guidelines require INR > 1.5, platelet count < 40 billion /l and normal APTT. In some instances the risk of not knowing the histology is so high that a biopsy is considered even with a more disturbed coagulation. Vitamin K, freshly frozen plasma and recombinant activated factor VII may reduce the risk of bleeding in specific situations, but no firm recommendations can be given. Udgivelsesdato: 2008-Nov-3

AB - The risk of severe bleeding after liver biopsy is estimated to be 1:12,000 in patients with near normal coagulation (INR < 1,5 and platelet count > 60 billion /l). Beyond these limits, the risk is higher, but still uncertain. The Danish guidelines require INR > 1.5, platelet count < 40 billion /l and normal APTT. In some instances the risk of not knowing the histology is so high that a biopsy is considered even with a more disturbed coagulation. Vitamin K, freshly frozen plasma and recombinant activated factor VII may reduce the risk of bleeding in specific situations, but no firm recommendations can be given. Udgivelsesdato: 2008-Nov-3

KW - Biopsy

KW - Blood Coagulation Disorders

KW - Hemorrhage

KW - Humans

KW - International Normalized Ratio

KW - Liver

KW - Liver Diseases

KW - Platelet Count

KW - Risk Factors

M3 - Tidsskriftartikel

SN - 0041-5782

VL - 170

SP - 3671

EP - 3673

ER -