Lokal trombolyse af sinustrombose

Nicolai Højmose Soll; Karsten Vestergård; Jørgen Nepper-Rasmussen

Lokal trombolyse af sinustrombose

Nicolai Højmose Soll, Karsten Vestergård, Jørgen Nepper-Rasmussen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

A 16-year-old girl was diagnosed with widely distributed dural sinus thrombosis (DST) and a haemorrhagic infarct in the left parietal lobe. Despite of heparin treatment, pronounced aggravation of symptoms was observed. Through a femoral vein approach a micro-catheter was advanced into the superior sagittal sinus and rt-PA was infused slowly, directly into the thrombus over 24 hours. A follow up angiogram showed recanalisation of sinus. The patient recovered almost completely, with only few remaining cognitive symptoms. This treatment remains experimental, but should be kept in mind for DST-patients unresponsive to heparin treatment.
Udgivelsesdato: 2009-Nov-2

Original language	Danish
Volume	171
Pages (from-to)	3284-5
Number of pages	1
ISSN	0041-5782
Publication status	Published - 2009
Externally published	Yes

Keywords

Adolescent
Catheterization
Contraceptives, Oral
Female
Fibrinolytic Agents
Follow-Up Studies
Humans
Infusions, Intralesional
Lateral Sinus Thrombosis
Sagittal Sinus Thrombosis
Superior Sagittal Sinus
Thrombolytic Therapy
Tissue Plasminogen Activator
Treatment Outcome
Venous Thrombosis

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Cite this

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title = "Lokal trombolyse af sinustrombose",

abstract = "A 16-year-old girl was diagnosed with widely distributed dural sinus thrombosis (DST) and a haemorrhagic infarct in the left parietal lobe. Despite of heparin treatment, pronounced aggravation of symptoms was observed. Through a femoral vein approach a micro-catheter was advanced into the superior sagittal sinus and rt-PA was infused slowly, directly into the thrombus over 24 hours. A follow up angiogram showed recanalisation of sinus. The patient recovered almost completely, with only few remaining cognitive symptoms. This treatment remains experimental, but should be kept in mind for DST-patients unresponsive to heparin treatment. Udgivelsesdato: 2009-Nov-2",

keywords = "Adolescent, Catheterization, Contraceptives, Oral, Female, Fibrinolytic Agents, Follow-Up Studies, Humans, Infusions, Intralesional, Lateral Sinus Thrombosis, Sagittal Sinus Thrombosis, Superior Sagittal Sinus, Thrombolytic Therapy, Tissue Plasminogen Activator, Treatment Outcome, Venous Thrombosis",

author = "Soll, {Nicolai H{\o}jmose} and Karsten Vesterg{\aa}rd and J{\o}rgen Nepper-Rasmussen",

year = "2009",

language = "Dansk",

volume = "171",

pages = "3284--5",

issn = "0041-5782",

publisher = "Almindelige Danske Laegeforening",

}

TY - JOUR

T1 - Lokal trombolyse af sinustrombose

AU - Soll, Nicolai Højmose

AU - Vestergård, Karsten

AU - Nepper-Rasmussen, Jørgen

PY - 2009

Y1 - 2009

N2 - A 16-year-old girl was diagnosed with widely distributed dural sinus thrombosis (DST) and a haemorrhagic infarct in the left parietal lobe. Despite of heparin treatment, pronounced aggravation of symptoms was observed. Through a femoral vein approach a micro-catheter was advanced into the superior sagittal sinus and rt-PA was infused slowly, directly into the thrombus over 24 hours. A follow up angiogram showed recanalisation of sinus. The patient recovered almost completely, with only few remaining cognitive symptoms. This treatment remains experimental, but should be kept in mind for DST-patients unresponsive to heparin treatment. Udgivelsesdato: 2009-Nov-2

AB - A 16-year-old girl was diagnosed with widely distributed dural sinus thrombosis (DST) and a haemorrhagic infarct in the left parietal lobe. Despite of heparin treatment, pronounced aggravation of symptoms was observed. Through a femoral vein approach a micro-catheter was advanced into the superior sagittal sinus and rt-PA was infused slowly, directly into the thrombus over 24 hours. A follow up angiogram showed recanalisation of sinus. The patient recovered almost completely, with only few remaining cognitive symptoms. This treatment remains experimental, but should be kept in mind for DST-patients unresponsive to heparin treatment. Udgivelsesdato: 2009-Nov-2

KW - Adolescent

KW - Catheterization

KW - Contraceptives, Oral

KW - Female

KW - Fibrinolytic Agents

KW - Follow-Up Studies

KW - Humans

KW - Infusions, Intralesional

KW - Lateral Sinus Thrombosis

KW - Sagittal Sinus Thrombosis

KW - Superior Sagittal Sinus

KW - Thrombolytic Therapy

KW - Tissue Plasminogen Activator

KW - Treatment Outcome

KW - Venous Thrombosis

M3 - Tidsskriftartikel

SN - 0041-5782

VL - 171

SP - 3284

EP - 3285

ER -