Long-term detection of SARS-CoV-2 antibodies after infection and risk of re-infection

Bo Langhoff Hønge; Lotte Hindhede; Kathrine Agergård Kaspersen; Lene Holm Harritshøj; Susan Mikkelsen; Dorte Kinggaard Holm; Anna Christine Nilsson; Susanne Gjørup Sækmose; Erik Sørensen; Bitten Aagaard; Henrik Hjalgrim; Charlotte Sværke Jørgensen; Tyra Grove Krause; Henrik Ullum; Ole Birger Vestager Pedersen; Sisse Rye Ostrowski; Christian Erikstrup

doi:10.1016/j.ijid.2022.01.041

Long-term detection of SARS-CoV-2 antibodies after infection and risk of re-infection

Bo Langhoff Hønge^*, Lotte Hindhede, Kathrine Agergård Kaspersen, Lene Holm Harritshøj, Susan Mikkelsen, Dorte Kinggaard Holm, Anna Christine Nilsson, Susanne Gjørup Sækmose, Erik Sørensen, Bitten Aagaard, Henrik Hjalgrim, Charlotte Sværke Jørgensen, Tyra Grove Krause, Henrik Ullum, Ole Birger Vestager Pedersen, Sisse Rye Ostrowski, Christian Erikstrup

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Objectives: To evaluate long-term sensitivity for detection of total antibodies against SARS-CoV-2 Methods: From week 41, 2020, through week 26, 2021, all Danish blood donations were tested for SARS-CoV-2 antibodies with the Wantai assay. The results were linked with polymerase chain reaction (PCR) test results from the Danish Microbiological Database (MiBa). Results: During the study period, 105,646 non-vaccinated Danish blood donors were tested for SARS-CoV-2 antibodies, and 3,806 (3.6%) had a positive PCR test before the blood donation. Among the donors with a positive PCR test, 94.2% subsequently also had a positive antibody test. The time between the positive PCR test and the antibody test was up to 15 months and there was no evidence of a decline in proportion with detectable antibodies over time. A negative serological result test was associated with a higher incidence of re-infection (Incidence Rate Ratio = 0.102 (95% confidence interval (CI): 0.039–0.262)). Conclusion: Among healthy blood donors, 94.2% developed SARS-CoV-2 antibodies after infection, and a lack of detectable antibodies was associated with re-infection.

Original language	English
Journal	International Journal of Infectious Diseases
Volume	116
Pages (from-to)	289-292
Number of pages	4
ISSN	1201-9712
DOIs	https://doi.org/10.1016/j.ijid.2022.01.041
Publication status	Published - Mar 2022

Bibliographical note

Keywords

SARS-CoV-2
Wantai
blood donors
sensitivity
seroprevalence

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10.1016/j.ijid.2022.01.041Licence: CC BY-NC-ND 4.0

Hønge et al. (2022). Long-term detection of SARS-CoV-2 antibodies after infection and risk of re-infectionFinal published version, 281 KBLicence: CC BY-NC-ND 4.0

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Hønge, B. L., Hindhede, L., Kaspersen, K. A., Harritshøj, L. H., Mikkelsen, S., Holm, D. K., Nilsson, A. C., Sækmose, S. G., Sørensen, E., Aagaard, B., Hjalgrim, H., Jørgensen, C. S., Krause, T. G., Ullum, H., Pedersen, O. B. V., Ostrowski, S. R., & Erikstrup, C. (2022). Long-term detection of SARS-CoV-2 antibodies after infection and risk of re-infection. International Journal of Infectious Diseases, 116, 289-292. Advance online publication. https://doi.org/10.1016/j.ijid.2022.01.041

@article{204437836bff47b19733835f4ec5b5ae,

title = "Long-term detection of SARS-CoV-2 antibodies after infection and risk of re-infection",

abstract = "Objectives: To evaluate long-term sensitivity for detection of total antibodies against SARS-CoV-2 Methods: From week 41, 2020, through week 26, 2021, all Danish blood donations were tested for SARS-CoV-2 antibodies with the Wantai assay. The results were linked with polymerase chain reaction (PCR) test results from the Danish Microbiological Database (MiBa). Results: During the study period, 105,646 non-vaccinated Danish blood donors were tested for SARS-CoV-2 antibodies, and 3,806 (3.6%) had a positive PCR test before the blood donation. Among the donors with a positive PCR test, 94.2% subsequently also had a positive antibody test. The time between the positive PCR test and the antibody test was up to 15 months and there was no evidence of a decline in proportion with detectable antibodies over time. A negative serological result test was associated with a higher incidence of re-infection (Incidence Rate Ratio = 0.102 (95% confidence interval (CI): 0.039–0.262)). Conclusion: Among healthy blood donors, 94.2% developed SARS-CoV-2 antibodies after infection, and a lack of detectable antibodies was associated with re-infection.",

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author = "H{\o}nge, {Bo Langhoff} and Lotte Hindhede and Kaspersen, {Kathrine Agerg{\aa}rd} and Harritsh{\o}j, {Lene Holm} and Susan Mikkelsen and Holm, {Dorte Kinggaard} and Nilsson, {Anna Christine} and S{\ae}kmose, {Susanne Gj{\o}rup} and Erik S{\o}rensen and Bitten Aagaard and Henrik Hjalgrim and J{\o}rgensen, {Charlotte Sv{\ae}rke} and Krause, {Tyra Grove} and Henrik Ullum and Pedersen, {Ole Birger Vestager} and Ostrowski, {Sisse Rye} and Christian Erikstrup",

year = "2022",

month = mar,

doi = "10.1016/j.ijid.2022.01.041",

language = "English",

volume = "116",

pages = "289--292",

journal = "International Journal of Infectious Diseases",

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Hønge, BL, Hindhede, L, Kaspersen, KA, Harritshøj, LH, Mikkelsen, S, Holm, DK, Nilsson, AC, Sækmose, SG, Sørensen, E, Aagaard, B, Hjalgrim, H, Jørgensen, CS, Krause, TG, Ullum, H, Pedersen, OBV, Ostrowski, SR & Erikstrup, C 2022, 'Long-term detection of SARS-CoV-2 antibodies after infection and risk of re-infection', International Journal of Infectious Diseases, vol. 116, pp. 289-292. https://doi.org/10.1016/j.ijid.2022.01.041

TY - JOUR

T1 - Long-term detection of SARS-CoV-2 antibodies after infection and risk of re-infection

AU - Hønge, Bo Langhoff

AU - Hindhede, Lotte

AU - Kaspersen, Kathrine Agergård

AU - Harritshøj, Lene Holm

AU - Mikkelsen, Susan

AU - Holm, Dorte Kinggaard

AU - Nilsson, Anna Christine

AU - Sækmose, Susanne Gjørup

AU - Sørensen, Erik

AU - Aagaard, Bitten

AU - Hjalgrim, Henrik

AU - Jørgensen, Charlotte Sværke

AU - Krause, Tyra Grove

AU - Ullum, Henrik

AU - Pedersen, Ole Birger Vestager

AU - Ostrowski, Sisse Rye

AU - Erikstrup, Christian

PY - 2022/3

Y1 - 2022/3

N2 - Objectives: To evaluate long-term sensitivity for detection of total antibodies against SARS-CoV-2 Methods: From week 41, 2020, through week 26, 2021, all Danish blood donations were tested for SARS-CoV-2 antibodies with the Wantai assay. The results were linked with polymerase chain reaction (PCR) test results from the Danish Microbiological Database (MiBa). Results: During the study period, 105,646 non-vaccinated Danish blood donors were tested for SARS-CoV-2 antibodies, and 3,806 (3.6%) had a positive PCR test before the blood donation. Among the donors with a positive PCR test, 94.2% subsequently also had a positive antibody test. The time between the positive PCR test and the antibody test was up to 15 months and there was no evidence of a decline in proportion with detectable antibodies over time. A negative serological result test was associated with a higher incidence of re-infection (Incidence Rate Ratio = 0.102 (95% confidence interval (CI): 0.039–0.262)). Conclusion: Among healthy blood donors, 94.2% developed SARS-CoV-2 antibodies after infection, and a lack of detectable antibodies was associated with re-infection.

AB - Objectives: To evaluate long-term sensitivity for detection of total antibodies against SARS-CoV-2 Methods: From week 41, 2020, through week 26, 2021, all Danish blood donations were tested for SARS-CoV-2 antibodies with the Wantai assay. The results were linked with polymerase chain reaction (PCR) test results from the Danish Microbiological Database (MiBa). Results: During the study period, 105,646 non-vaccinated Danish blood donors were tested for SARS-CoV-2 antibodies, and 3,806 (3.6%) had a positive PCR test before the blood donation. Among the donors with a positive PCR test, 94.2% subsequently also had a positive antibody test. The time between the positive PCR test and the antibody test was up to 15 months and there was no evidence of a decline in proportion with detectable antibodies over time. A negative serological result test was associated with a higher incidence of re-infection (Incidence Rate Ratio = 0.102 (95% confidence interval (CI): 0.039–0.262)). Conclusion: Among healthy blood donors, 94.2% developed SARS-CoV-2 antibodies after infection, and a lack of detectable antibodies was associated with re-infection.

KW - SARS-CoV-2

KW - Wantai

KW - blood donors

KW - sensitivity

KW - seroprevalence

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U2 - 10.1016/j.ijid.2022.01.041

DO - 10.1016/j.ijid.2022.01.041

M3 - Journal article

C2 - 35077881

SN - 1201-9712

VL - 116

SP - 289

EP - 292

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

ER -

Long-term detection of SARS-CoV-2 antibodies after infection and risk of re-infection

Abstract

Bibliographical note

Keywords

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