TY - JOUR
T1 - Long-Term Glucose-Lowering Effect of Intermittently Scanned Continuous Glucose Monitoring for Type 1 Diabetes Patients in Poor Glycaemic Control from Region North Denmark
T2 - An Observational Real-World Cohort Study
AU - Jensen, Morten Hasselstrøm
AU - Cichosz, Simon Lebech
AU - Gustenhoff, Peter
AU - Nikontovic, Amar
AU - Hejlesen, Ole
AU - Vestergaard, Peter
PY - 2022/10/14
Y1 - 2022/10/14
N2 - Background Lowering glucose levels is a complex task for patients with type 1 diabetes, and they often lack contact with health care professionals. Intermittently scanned continuous glucose monitoring (isCGM) has the potential to aid them with blood glucose management at home. The aim of this study was to investigate the long-term effect of isCGM on HbA
1c in type 1 diabetes patients with poor glycaemic control in a region-wide real-world setting. Methods All patients with type 1 diabetes receiving an isCGM due to poor glycaemic control (≥70 mmol/mol [≥8.6%]) in the period of 2020–21 in Region North Denmark (“T1D-CGM”) were compared with all type 1 diabetes patients without isCGM (“T1D-NOCGM”) in the same period. A multiple linear regression model adjusted for age, sex, diabetes duration and use of continuous subcutaneous insulin infusion was constructed to estimate the difference in change from baseline HbA
1c between the two groups and within subgroups of T1D-CGM. Results A total of 2,527 patients (T1D-CGM: 897; T1D-NOCGM: 1,630) were included in the study. The estimated adjusted difference in change from baseline HbA
1c between T1D-CGM vs T1D-NOCGM was -5.68 mmol/mol (95% CI: (-6.69 to -4.67 mmol/mol; p<0.0001)). Older patients using isCGM dropped less in HbA
1c. Conclusions Our results indicate that patients with type 1 diabetes in poor glycaemic control from Region North Denmark in general benefit from using isCGM with a sustained 24-month improvement in HbA
1c, but the effect on HbA
1c may be less pronounced for older patients.
AB - Background Lowering glucose levels is a complex task for patients with type 1 diabetes, and they often lack contact with health care professionals. Intermittently scanned continuous glucose monitoring (isCGM) has the potential to aid them with blood glucose management at home. The aim of this study was to investigate the long-term effect of isCGM on HbA
1c in type 1 diabetes patients with poor glycaemic control in a region-wide real-world setting. Methods All patients with type 1 diabetes receiving an isCGM due to poor glycaemic control (≥70 mmol/mol [≥8.6%]) in the period of 2020–21 in Region North Denmark (“T1D-CGM”) were compared with all type 1 diabetes patients without isCGM (“T1D-NOCGM”) in the same period. A multiple linear regression model adjusted for age, sex, diabetes duration and use of continuous subcutaneous insulin infusion was constructed to estimate the difference in change from baseline HbA
1c between the two groups and within subgroups of T1D-CGM. Results A total of 2,527 patients (T1D-CGM: 897; T1D-NOCGM: 1,630) were included in the study. The estimated adjusted difference in change from baseline HbA
1c between T1D-CGM vs T1D-NOCGM was -5.68 mmol/mol (95% CI: (-6.69 to -4.67 mmol/mol; p<0.0001)). Older patients using isCGM dropped less in HbA
1c. Conclusions Our results indicate that patients with type 1 diabetes in poor glycaemic control from Region North Denmark in general benefit from using isCGM with a sustained 24-month improvement in HbA
1c, but the effect on HbA
1c may be less pronounced for older patients.
KW - Blood Glucose
KW - Blood Glucose Self-Monitoring/methods
KW - Cohort Studies
KW - Denmark
KW - Diabetes Mellitus, Type 1/drug therapy
KW - Glucose
KW - Glycated Hemoglobin A/analysis
KW - Glycemic Control
KW - Humans
KW - Hyperglycemia
KW - Insulin/therapeutic use
UR - http://www.scopus.com/inward/record.url?scp=85139885192&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0274626
DO - 10.1371/journal.pone.0274626
M3 - Journal article
C2 - 36240184
SN - 1932-6203
VL - 17
JO - PLoS ONE
JF - PLoS ONE
IS - 10
M1 - e0274626
ER -