Long-term impact of baseline anaemia on clinical outcomes following percutaneous coronary intervention in stable angina

Line Davidsen; Kristian Hay Kragholm; Mette Aldahl; Christoffer Polcwiartek; Christian Torp-Pedersen; Peter Soegaard; Phillip Freeman

doi:10.1136/openhrt-2020-001319

Long-term impact of baseline anaemia on clinical outcomes following percutaneous coronary intervention in stable angina

Line Davidsen, Kristian Hay Kragholm, Mette Aldahl, Christoffer Polcwiartek, Christian Torp-Pedersen, Peter Soegaard, Phillip Freeman

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

BACKGROUND: In patients with stable angina (SA), the clinical benefits of percutaneous coronary intervention (PCI) reside almost exclusively within the realm of symptomatic improvement rather than improvement in hard clinical endpoints. The benefits of PCI should always be balanced against its potential short-term and long-term risks. Common among these risks is the presence of anaemia and its interaction with poor clinical outcomes and increased morbidity; this study aims to elucidate the impact of anaemia on long-term clinical outcomes of this patient group.

METHODS: From Danish national registries, we identified patients with SA treated with PCI who had a haemoglobin measurement maximum of 90 days prior to PCI procedure. Anaemia was defined as haemoglobin <130 and <120 g/L in men and women, respectively. Follow-up was up to 3 years after PCI, and Cox regression was used to estimate HRs with 95% CIs of hospitalisation due to bleeding, acute coronary syndrome (ACS) and all-cause mortality in patients with anaemia compared with patients without anaemia.

RESULTS: Of 2837 included patients, 14.6% had anaemia prior to PCI. During follow-up, 93 patients (3.3%) had a bleeding episode, which was higher in patients with anaemia (5.8%) compared with patients without anaemia (2.8%). A total of 213 patients (7.5%) developed ACS, which was higher in patients with anaemia (10.6%) compared with patients without anaemia (7.0%). Furthermore, 185 patients (6.5%) died, with a mortality rate of 18.1% in patients with anaemia compared with 4.5% in patients without anaemia. In multivariable analyses, anaemia was associated with a significantly increased risk of bleeding (HR 1.69; 95% CI 1.04 to 2.73; P 0.033), ACS (HR 1.47; 95% CI 1.04 to 2.10; P 0.031) and all-cause mortality (HR 2.41; 95% CI 1.73 to 3.30; P <0.001).

CONCLUSION: Anaemia in patients with SA was significantly associated with bleeding, ACS and all-cause mortality following PCI.

Original language	English
Article number	e001319
Journal	Open Heart
Volume	7
Issue number	2
Number of pages	7
ISSN	2053-3624
DOIs	https://doi.org/10.1136/openhrt-2020-001319
Publication status	Published - Oct 2020

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@article{d987739f2c4e4bbca0e722a9a0cd6f55,

title = "Long-term impact of baseline anaemia on clinical outcomes following percutaneous coronary intervention in stable angina",

abstract = "BACKGROUND: In patients with stable angina (SA), the clinical benefits of percutaneous coronary intervention (PCI) reside almost exclusively within the realm of symptomatic improvement rather than improvement in hard clinical endpoints. The benefits of PCI should always be balanced against its potential short-term and long-term risks. Common among these risks is the presence of anaemia and its interaction with poor clinical outcomes and increased morbidity; this study aims to elucidate the impact of anaemia on long-term clinical outcomes of this patient group.METHODS: From Danish national registries, we identified patients with SA treated with PCI who had a haemoglobin measurement maximum of 90 days prior to PCI procedure. Anaemia was defined as haemoglobin <130 and <120 g/L in men and women, respectively. Follow-up was up to 3 years after PCI, and Cox regression was used to estimate HRs with 95% CIs of hospitalisation due to bleeding, acute coronary syndrome (ACS) and all-cause mortality in patients with anaemia compared with patients without anaemia.RESULTS: Of 2837 included patients, 14.6% had anaemia prior to PCI. During follow-up, 93 patients (3.3%) had a bleeding episode, which was higher in patients with anaemia (5.8%) compared with patients without anaemia (2.8%). A total of 213 patients (7.5%) developed ACS, which was higher in patients with anaemia (10.6%) compared with patients without anaemia (7.0%). Furthermore, 185 patients (6.5%) died, with a mortality rate of 18.1% in patients with anaemia compared with 4.5% in patients without anaemia. In multivariable analyses, anaemia was associated with a significantly increased risk of bleeding (HR 1.69; 95% CI 1.04 to 2.73; P 0.033), ACS (HR 1.47; 95% CI 1.04 to 2.10; P 0.031) and all-cause mortality (HR 2.41; 95% CI 1.73 to 3.30; P <0.001).CONCLUSION: Anaemia in patients with SA was significantly associated with bleeding, ACS and all-cause mortality following PCI.",

author = "Line Davidsen and Kragholm, {Kristian Hay} and Mette Aldahl and Christoffer Polcwiartek and Christian Torp-Pedersen and Peter Soegaard and Phillip Freeman",

year = "2020",

month = oct,

doi = "10.1136/openhrt-2020-001319",

language = "English",

volume = "7",

journal = "Open Heart",

issn = "2053-3624",

publisher = "BMJ ",

number = "2",

}

TY - JOUR

T1 - Long-term impact of baseline anaemia on clinical outcomes following percutaneous coronary intervention in stable angina

AU - Davidsen, Line

AU - Kragholm, Kristian Hay

AU - Aldahl, Mette

AU - Polcwiartek, Christoffer

AU - Torp-Pedersen, Christian

AU - Soegaard, Peter

AU - Freeman, Phillip

PY - 2020/10

Y1 - 2020/10

N2 - BACKGROUND: In patients with stable angina (SA), the clinical benefits of percutaneous coronary intervention (PCI) reside almost exclusively within the realm of symptomatic improvement rather than improvement in hard clinical endpoints. The benefits of PCI should always be balanced against its potential short-term and long-term risks. Common among these risks is the presence of anaemia and its interaction with poor clinical outcomes and increased morbidity; this study aims to elucidate the impact of anaemia on long-term clinical outcomes of this patient group.METHODS: From Danish national registries, we identified patients with SA treated with PCI who had a haemoglobin measurement maximum of 90 days prior to PCI procedure. Anaemia was defined as haemoglobin <130 and <120 g/L in men and women, respectively. Follow-up was up to 3 years after PCI, and Cox regression was used to estimate HRs with 95% CIs of hospitalisation due to bleeding, acute coronary syndrome (ACS) and all-cause mortality in patients with anaemia compared with patients without anaemia.RESULTS: Of 2837 included patients, 14.6% had anaemia prior to PCI. During follow-up, 93 patients (3.3%) had a bleeding episode, which was higher in patients with anaemia (5.8%) compared with patients without anaemia (2.8%). A total of 213 patients (7.5%) developed ACS, which was higher in patients with anaemia (10.6%) compared with patients without anaemia (7.0%). Furthermore, 185 patients (6.5%) died, with a mortality rate of 18.1% in patients with anaemia compared with 4.5% in patients without anaemia. In multivariable analyses, anaemia was associated with a significantly increased risk of bleeding (HR 1.69; 95% CI 1.04 to 2.73; P 0.033), ACS (HR 1.47; 95% CI 1.04 to 2.10; P 0.031) and all-cause mortality (HR 2.41; 95% CI 1.73 to 3.30; P <0.001).CONCLUSION: Anaemia in patients with SA was significantly associated with bleeding, ACS and all-cause mortality following PCI.

AB - BACKGROUND: In patients with stable angina (SA), the clinical benefits of percutaneous coronary intervention (PCI) reside almost exclusively within the realm of symptomatic improvement rather than improvement in hard clinical endpoints. The benefits of PCI should always be balanced against its potential short-term and long-term risks. Common among these risks is the presence of anaemia and its interaction with poor clinical outcomes and increased morbidity; this study aims to elucidate the impact of anaemia on long-term clinical outcomes of this patient group.METHODS: From Danish national registries, we identified patients with SA treated with PCI who had a haemoglobin measurement maximum of 90 days prior to PCI procedure. Anaemia was defined as haemoglobin <130 and <120 g/L in men and women, respectively. Follow-up was up to 3 years after PCI, and Cox regression was used to estimate HRs with 95% CIs of hospitalisation due to bleeding, acute coronary syndrome (ACS) and all-cause mortality in patients with anaemia compared with patients without anaemia.RESULTS: Of 2837 included patients, 14.6% had anaemia prior to PCI. During follow-up, 93 patients (3.3%) had a bleeding episode, which was higher in patients with anaemia (5.8%) compared with patients without anaemia (2.8%). A total of 213 patients (7.5%) developed ACS, which was higher in patients with anaemia (10.6%) compared with patients without anaemia (7.0%). Furthermore, 185 patients (6.5%) died, with a mortality rate of 18.1% in patients with anaemia compared with 4.5% in patients without anaemia. In multivariable analyses, anaemia was associated with a significantly increased risk of bleeding (HR 1.69; 95% CI 1.04 to 2.73; P 0.033), ACS (HR 1.47; 95% CI 1.04 to 2.10; P 0.031) and all-cause mortality (HR 2.41; 95% CI 1.73 to 3.30; P <0.001).CONCLUSION: Anaemia in patients with SA was significantly associated with bleeding, ACS and all-cause mortality following PCI.

U2 - 10.1136/openhrt-2020-001319

DO - 10.1136/openhrt-2020-001319

M3 - Journal article

C2 - 33004620

SN - 2053-3624

VL - 7

JO - Open Heart

JF - Open Heart

IS - 2

M1 - e001319

ER -