Abstract
In a study of lymphocyte subpopulations in peripheral blood during infectious mononucleosis the lymphocytosis was found to be of T-cell origin (i.e. E-RFC), while the number of non T lymphocytes (i.e. EA-, EAC-RFC and SmIg + ve cells) was normal in 7 out of 8 patients. Ten patients were tested for the presence of HLA-DR determinants on their B and T cells and not only B lymphocytes but also a great part (31--75%) of T cells were lysed by the anti HLA-DR testsera, indicating that HLA-DR determinants are expressed on a population of T cells in IM patients. After recovery all patients were retested and showed a normal pattern of HLA-DR typing. This indicates an increase of HLA-DR antigens on T cells or a vigorous proliferation of a small DR-positive T-cell subpopulation during the acute stage of IM.
| Original language | English |
|---|---|
| Journal | Acta pathologica et microbiologica Scandinavica. Section C, Immunology |
| Volume | 86C |
| Issue number | 6 |
| Pages (from-to) | 307-14 |
| Number of pages | 8 |
| ISSN | 0304-1328 |
| Publication status | Published - Dec 1978 |
| Externally published | Yes |
Keywords
- Absorption
- Adolescent
- Adult
- Antigens, Surface
- B-Lymphocytes
- Child
- Epitopes
- Female
- HLA Antigens
- Humans
- Infectious Mononucleosis
- Male
- Rosette Formation
- T-Lymphocytes