TY - JOUR
T1 - Management of Endocrine Disease
T2 - Diabetes and osteoporosis: cause for concern?
AU - Starup-Linde, Jakob
AU - Vestergaard, Peter
N1 - This article has been found as a 'Free Version' from the Publisher on July 26th 2018. When the access to the article closes, please notify vbn@aub.aau.dk”
PY - 2015/9
Y1 - 2015/9
N2 - Diabetes and osteoporosis are both frequent conditions, and they may thus occur simultaneously by chance. However, a growing body of evidence suggests that hyperglycemia may impair bone matrix formation and biochemical competence. Decreased biomechanical competence may be present even in a setting of increased bone mineral density, as assessed by traditional dual energy X-ray absorptiometry or normal structural parameters by quantitative computed tomography. Also, the absence of endogenous insulin secretion in type 1 diabetes (T1D) and insulin resistance or, in some cases, frank hyperinsulinemia in T2D may play a role.
AB - Diabetes and osteoporosis are both frequent conditions, and they may thus occur simultaneously by chance. However, a growing body of evidence suggests that hyperglycemia may impair bone matrix formation and biochemical competence. Decreased biomechanical competence may be present even in a setting of increased bone mineral density, as assessed by traditional dual energy X-ray absorptiometry or normal structural parameters by quantitative computed tomography. Also, the absence of endogenous insulin secretion in type 1 diabetes (T1D) and insulin resistance or, in some cases, frank hyperinsulinemia in T2D may play a role.
UR - http://www.eje-online.org/content/173/3/R93.full.pdf
U2 - 10.1530/EJE-15-0155
DO - 10.1530/EJE-15-0155
M3 - Review article
C2 - 26243638
SN - 0804-4643
VL - 173
SP - R93-99
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
IS - 3
ER -