Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer

H Ytting; I J Christensen; Rudi Nora Steffensen; Jan Alsner; Steffen Thiel; Jens Christian Jensenius; U Hansen; H J Nielsen

doi:10.1111/j.1365-3083.2010.02480.x

Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer

H Ytting, I J Christensen, Rudi Nora Steffensen, Jan Alsner, Steffen Thiel, Jens Christian Jensenius, U Hansen, H J Nielsen

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

Abstract

Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) are key factors of the lectin pathway of complement activation. Polymorphisms of the MBL2 and MASP-2 genes affect serum levels of MBL and MASP-2. In patients with colorectal cancer (CRC), the MBL and MASP-2 serum levels are increased and high MASP-2 levels are associated with recurrence and poor survival, whereas low MBL levels predict post-operative pneumonia. It is not known whether these associations are genetically based. In this study, the MBL and MASP-2 genotypes are investigated in 593 patients with CRC and 348 healthy controls. The potential association between genetic profile and infections, recurrence and survival is evaluated. Four single-nucleotide polymorphisms (SNPs) of MBL2 were analysed using TaqMan assays, with characterization of MBL2 wildtype A, variants B, C and D and alleles H/L, Y/X and P/Q. The SNP D120G for MASP-2 was determined. Serum levels of MBL and MASP-2 were measured. The MBL2 and MASP-2 genotype distribution was similar among patients with CRC and healthy controls and MBL2 genotype significantly associated with MBL concentration in serum (P

Original language	English
Journal	Scandinavian Journal of Immunology
Volume	73
Pages (from-to)	122-7
Number of pages	6
ISSN	0300-9475
DOIs	https://doi.org/10.1111/j.1365-3083.2010.02480.x
Publication status	Published - 1 Feb 2011
Externally published	Yes

Bibliographical note

Keywords

Adult
Aged
Aged, 80 and over
Colorectal Neoplasms
Female
Genotype
Humans
Male
Mannose-Binding Lectin
Mannose-Binding Protein-Associated Serine Proteases
Middle Aged
Treatment Outcome

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title = "Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer",

abstract = "Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) are key factors of the lectin pathway of complement activation. Polymorphisms of the MBL2 and MASP-2 genes affect serum levels of MBL and MASP-2. In patients with colorectal cancer (CRC), the MBL and MASP-2 serum levels are increased and high MASP-2 levels are associated with recurrence and poor survival, whereas low MBL levels predict post-operative pneumonia. It is not known whether these associations are genetically based. In this study, the MBL and MASP-2 genotypes are investigated in 593 patients with CRC and 348 healthy controls. The potential association between genetic profile and infections, recurrence and survival is evaluated. Four single-nucleotide polymorphisms (SNPs) of MBL2 were analysed using TaqMan assays, with characterization of MBL2 wildtype A, variants B, C and D and alleles H/L, Y/X and P/Q. The SNP D120G for MASP-2 was determined. Serum levels of MBL and MASP-2 were measured. The MBL2 and MASP-2 genotype distribution was similar among patients with CRC and healthy controls and MBL2 genotype significantly associated with MBL concentration in serum (P",

keywords = "Adult, Aged, Aged, 80 and over, Colorectal Neoplasms, Female, Genotype, Humans, Male, Mannose-Binding Lectin, Mannose-Binding Protein-Associated Serine Proteases, Middle Aged, Treatment Outcome",

author = "H Ytting and Christensen, {I J} and Steffensen, {Rudi Nora} and Jan Alsner and Steffen Thiel and Jensenius, {Jens Christian} and U Hansen and Nielsen, {H J}",

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doi = "10.1111/j.1365-3083.2010.02480.x",

language = "English",

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pages = "122--7",

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TY - JOUR

T1 - Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer

AU - Ytting, H

AU - Christensen, I J

AU - Steffensen, Rudi Nora

AU - Alsner, Jan

AU - Thiel, Steffen

AU - Jensenius, Jens Christian

AU - Hansen, U

AU - Nielsen, H J

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) are key factors of the lectin pathway of complement activation. Polymorphisms of the MBL2 and MASP-2 genes affect serum levels of MBL and MASP-2. In patients with colorectal cancer (CRC), the MBL and MASP-2 serum levels are increased and high MASP-2 levels are associated with recurrence and poor survival, whereas low MBL levels predict post-operative pneumonia. It is not known whether these associations are genetically based. In this study, the MBL and MASP-2 genotypes are investigated in 593 patients with CRC and 348 healthy controls. The potential association between genetic profile and infections, recurrence and survival is evaluated. Four single-nucleotide polymorphisms (SNPs) of MBL2 were analysed using TaqMan assays, with characterization of MBL2 wildtype A, variants B, C and D and alleles H/L, Y/X and P/Q. The SNP D120G for MASP-2 was determined. Serum levels of MBL and MASP-2 were measured. The MBL2 and MASP-2 genotype distribution was similar among patients with CRC and healthy controls and MBL2 genotype significantly associated with MBL concentration in serum (P

AB - Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) are key factors of the lectin pathway of complement activation. Polymorphisms of the MBL2 and MASP-2 genes affect serum levels of MBL and MASP-2. In patients with colorectal cancer (CRC), the MBL and MASP-2 serum levels are increased and high MASP-2 levels are associated with recurrence and poor survival, whereas low MBL levels predict post-operative pneumonia. It is not known whether these associations are genetically based. In this study, the MBL and MASP-2 genotypes are investigated in 593 patients with CRC and 348 healthy controls. The potential association between genetic profile and infections, recurrence and survival is evaluated. Four single-nucleotide polymorphisms (SNPs) of MBL2 were analysed using TaqMan assays, with characterization of MBL2 wildtype A, variants B, C and D and alleles H/L, Y/X and P/Q. The SNP D120G for MASP-2 was determined. Serum levels of MBL and MASP-2 were measured. The MBL2 and MASP-2 genotype distribution was similar among patients with CRC and healthy controls and MBL2 genotype significantly associated with MBL concentration in serum (P

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Colorectal Neoplasms

KW - Female

KW - Genotype

KW - Humans

KW - Male

KW - Mannose-Binding Lectin

KW - Mannose-Binding Protein-Associated Serine Proteases

KW - Middle Aged

KW - Treatment Outcome

U2 - 10.1111/j.1365-3083.2010.02480.x

DO - 10.1111/j.1365-3083.2010.02480.x

M3 - Journal article

SN - 0300-9475

VL - 73

SP - 122

EP - 127

JO - Scandinavian Journal of Immunology

JF - Scandinavian Journal of Immunology

ER -

Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer

Abstract

Bibliographical note

Keywords

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